Millisecond-timescale, genetically targeted optical control of neural activity

Edward S Boyden; Feng Zhang; Ernst Bamberg; Georg Nagel; Karl Deisseroth

doi:10.1038/nn1525

journal article Aug 14, 2005

Millisecond-timescale, genetically targeted optical control of neural activity

Edward S Boyden Feng Zhang

Ernst Bamberg

Georg Nagel Karl Deisseroth

Nature Neuroscience Vol. 8 No. 9 pp. 1263-1268 · Springer Science and Business Media LLC

View at Publisher Save 10.1038/nn1525

Topics

No keywords indexed for this article. Browse by subject →

References

30

[1]

Kandel, E.R., Spencer, W.A. & Brinley, F.J., Jr. Electrophysiology of hippocampal neurons. I. Sequential invasion and synaptic organization. J. Neurophysiol. 24, 225–242 (1961). 10.1152/jn.1961.24.3.225

[2]

Ditterich, J., Mazurek, M.E. & Shadlen, M.N. Microstimulation of visual cortex affects the speed of perceptual decisions. Nat. Neurosci. 6, 891–898 (2003). 10.1038/nn1094

[3]

Salzman, C.D., Britten, K.H. & Newsome, W.T. Cortical microstimulation influences perceptual judgements of motion direction. Nature 346, 174–177 (1990). 10.1038/346174a0

[4]

Shepherd, G.M., Pologruto, T.A. & Svoboda, K. Circuit analysis of experience-dependent plasticity in the developing rat barrel cortex. Neuron 38, 277–289 (2003). 10.1016/s0896-6273(03)00152-1

[5]

Pettit, D.L., Helms, M.C., Lee, P., Augustine, G.J. & Hall, W.C. Local excitatory circuits in the intermediate gray layer of the superior colliculus. J. Neurophysiol. 81, 1424–1427 (1999). 10.1152/jn.1999.81.3.1424

[6]

Yoshimura, Y., Dantzker, J.L. & Callaway, E.M. Excitatory cortical neurons form fine-scale functional networks. Nature 433, 868–873 (2005). 10.1038/nature03252

[7]

Dalva, M.B. & Katz, L.C. Rearrangements of synaptic connections in visual cortex revealed by laser photostimulation. Science 265, 255–258 (1994). 10.1126/science.7912852

[8]

Lima, S.Q. & Miesenbock, G. Remote control of behavior through genetically targeted photostimulation of neurons. Cell 121, 141–152 (2005). 10.1016/j.cell.2005.02.004

[9]

Light-activated ion channels for remote control of neuronal firing

Matthew Banghart, Katharine Borges, Ehud Isacoff et al.

Nature Neuroscience 2004 10.1038/nn1356

[10]

Zemelman, B.V., Nesnas, N., Lee, G.A. & Miesenbock, G. Photochemical gating of heterologous ion channels: remote control over genetically designated populations of neurons. Proc. Natl. Acad. Sci. USA 100, 1352–1357 (2003). 10.1073/pnas.242738899

[11]

Zemelman, B.V., Lee, G.A., Ng, M. & Miesenbock, G. Selective photostimulation of genetically chARGed neurons. Neuron 33, 15–22 (2002). 10.1016/s0896-6273(01)00574-8

[12]

Nagel, G. et al. Channelrhodopsin-2, a directly light-gated cation-selective membrane channel. Proc. Natl. Acad. Sci. USA 100, 13940–13945 (2003). 10.1073/pnas.1936192100

[13]

Nagel, G. et al. Channelrhodopsin-1: a light-gated proton channel in green algae. Science 296, 2395–2398 (2002). 10.1126/science.1072068

[14]

Two rhodopsins mediate phototaxis to low- and high-intensity light in Chlamydomonas reinhardtii

Oleg A. Sineshchekov, Kwang-Hwan Jung, John L. Spudich

Proceedings of the National Academy of Sciences 2002 10.1073/pnas.122243399

[15]

Archaeal-type rhodopsins in Chlamydomonas: model structure and intracellular localization

Takeshi Suzuki, Kenta Yamasaki, Satoshi Fujita et al.

Biochemical and Biophysical Research Communication... 2003 10.1016/s0006-291x(02)03079-6

[16]

Harz, H. & Hegemann, P. Rhodopsin-regulated calcium currents in Chlamydomonas. Nature 351, 489–491 (1991). 10.1038/351489a0

[17]

Mainen, Z.F. & Sejnowski, T.J. Reliability of spike timing in neocortical neurons. Science 268, 1503–1506 (1995). 10.1126/science.7770778

[18]

Mermelstein, P.G., Bito, H., Deisseroth, K. & Tsien, R.W. Critical dependence of cAMP response element-binding protein phosphorylation on L-type calcium channels supports a selective response to EPSPs in preference to action potentials. J. Neurosci. 20, 266–273 (2000). 10.1523/jneurosci.20-01-00266.2000

[19]

Bi, G.Q. & Poo, M.M. Synaptic modifications in cultured hippocampal neurons: dependence on spike timing, synaptic strength, and postsynaptic cell type. J. Neurosci. 18, 10464–10472 (1998). 10.1523/jneurosci.18-24-10464.1998

[20]

Katz, L.C. & Dalva, M.B. Scanning laser photostimulation: a new approach for analyzing brain circuits. J. Neurosci. Methods 54, 205–218 (1994). 10.1016/0165-0270(94)90194-5

[21]

Dantzker, J.L. & Callaway, E.M. Laminar sources of synaptic input to cortical inhibitory interneurons and pyramidal neurons. Nat. Neurosci. 3, 701–707 (2000). 10.1038/76656

[22]

Schubert, D. et al. Layer-specific intracolumnar and transcolumnar functional connectivity of layer V pyramidal cells in rat barrel cortex. J. Neurosci. 21, 3580–3592 (2001). 10.1523/jneurosci.21-10-03580.2001

[23]

Hirase, H., Nikolenko, V., Goldberg, J.H. & Yuste, R. Multiphoton stimulation of neurons. J. Neurobiol. 51, 237–247 (2002). 10.1002/neu.10056

[24]

Ikegaya, Y. et al. Synfire chains and cortical songs: temporal modules of cortical activity. Science 304, 559–564 (2004). 10.1126/science.1093173

[25]

Kozloski, J., Hamzei-Sichani, F. & Yuste, R. Stereotyped position of local synaptic targets in neocortex. Science 293, 868–872 (2001). 10.1126/science.293.5531.868

[26]

Pouille, F. & Scanziani, M. Routing of spike series by dynamic circuits in the hippocampus. Nature 429, 717–723 (2004). 10.1038/nature02615

[27]

Graziano, M.S., Taylor, C.S. & Moore, T. Complex movements evoked by microstimulation of precentral cortex. Neuron 34, 841–851 (2002). 10.1016/s0896-6273(02)00698-0

[28]

Moore, T. & Armstrong, K.M. Selective gating of visual signals by microstimulation of frontal cortex. Nature 421, 370–373 (2003). 10.1038/nature01341

[29]

Deisseroth, K. et al. Excitation-neurogenesis coupling in adult neural stem/progenitor cells. Neuron 42, 535–552 (2004). 10.1016/s0896-6273(04)00266-1

[30]

Dull, T. et al. A third-generation lentivirus vector with a conditional packaging system. J. Virol. 72, 8463–8471 (1998). 10.1128/jvi.72.11.8463-8471.1998

Cited By

4,208

Chemical, biological, and medical frontiers in multicellular complex systems

Zimo Chen, Hongru Tao · 2026

SCIENTIA SINICA Chimica

Minimally invasive upconversion optogenetics for Parkinson's disease treatment

Xinsheng Li, Xiaoran Wang · 2026

Biomaterials

Optogenetics as a useful tool to control excitable and non-excitable tissues during chicken embryogenesis

Masafumi Inaba, Yuuki Shikaya · 2026

Developmental Biology

A dorsal hippocampus-prodynorphinergic dorsolateral septum-to-lateral hypothalamus circuit mediates contextual gating of feeding

Travis D. Goode, Mollie X. Bernstein · 2026

Neuron

Controlling the human connectome with spatially diffuse input signals

Richard Betzel, Maria Grazia Puxeddu · 2026

Communications Biology

Remote control of bacterial gene expression: Optogenetics, electrogenetics, sonogenetics and magnetogenetics

Youli Jiang, Zihao Mo · 2026

Chemical Engineering Journal

A Review of Hydrogel Fiber: Design, Synthesis, Applications, and Futures

Guoyin Chen, Zijie Yang · 2025

Chemical Reviews

Striatum supports fast learning but not memory recall

Kimberly Reinhold, Marci Iadarola · 2025

Nature

Advances and future trends in real-time precision optical control of chemical processes in live cells

Chi Zhang, Bin Dong · 2025

npj Imaging

Probing neuronal activity with genetically encoded calcium and voltage fluorescent indicators

Masayuki Sakamoto, Tatsushi Yokoyama · 2025

Neuroscience Research

Clusterin Regulates the Mechanisms of Neuroinflammation and Neuronal Circuit Impairment in Alzheimer’s Disease

Yihang Yu, Chunjian Wang · 2025

International Journal of Molecular...

Multifunctional bioelectronics for brain–body circuits

Atharva Sahasrabudhe, Claudia Cea · 2025

Nature Reviews Bioengineering

Intrinsic electrical activity drives small-cell lung cancer progression

Paola Peinado, Marco Stazi · 2025

Nature

Classical and Entangled Two-Photon Absorption of Microbial Rhodopsin KR2 and Its Red-Shifted Mutant

P. A. Kusochek, V. V. Belov · 2025

Russian Journal of Physical Chemist...

Impact of the Protein Environment on Two-Photon Absorption Cross-Sections of Type I and Type II Retinal-Containing Proteins

P. A. Kusochek, V. I. Nazarova · 2025

Moscow University Chemistry Bulleti...

光纤传感技术发展的新趋势——生物医学领域的需求与应用（特邀）

苑婷婷 Yuan Tingting, 张晓彤 Zhang Xiaotong · 2025

Acta Optica Sinica

Protocol for artificial intelligence-guided neural control using deep reinforcement learning and infrared neural stimulation

Brandon S. Coventry, Edward L. Bartlett · 2025

STAR Protocols

A roadmap for transformative translational research on gambling disorder in the UK

Tristan Hynes, Henrietta Bowden-Jones · 2025

Neuroscience & Biobehavioral Re...

An Integrated Neural Optrode with Modification of Polymer-Carbon Composite Films for Suppression of the Photoelectric Artifacts

Yanyan Xu, Xien Yang · 2024

ACS Omega

Optogenetic fMRI reveals therapeutic circuits of subthalamic nucleus deep brain stimulation

Yuhui Li, Sung-Ho Lee · 2024

Brain Stimulation

Metrics

4,208

Citations

30

References

Details

Published: Aug 14, 2005
Vol/Issue: 8(9)
Pages: 1263-1268
License: View

Authors

Hebei Agricultural University

Cite This Article

Edward S Boyden, Feng Zhang, Ernst Bamberg, et al. (2005). Millisecond-timescale, genetically targeted optical control of neural activity. Nature Neuroscience, 8(9), 1263-1268. https://doi.org/10.1038/nn1525

Millisecond-timescale, genetically targeted optical control of neural activity

You May Also Like