Cold-induced activation of brown adipose tissue and adipose angiogenesis in mice

Sharon Lim; Jennifer Honek; Yuan Xue; Takahiro Seki; Ziquan Cao; Patrik Andersson; Xiaojuan Yang; Kayoko Hosaka; Yihai Cao

doi:10.1038/nprot.2012.013

journal article Mar 01, 2012

Cold-induced activation of brown adipose tissue and adipose angiogenesis in mice

Sharon Lim Jennifer Honek Yuan Xue

Takahiro Seki Ziquan Cao Patrik Andersson

Xiaojuan Yang

Kayoko Hosaka Yihai Cao

Nature Protocols Vol. 7 No. 3 pp. 606-615 · Springer Science and Business Media LLC

View at Publisher Save 10.1038/nprot.2012.013

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References

15

[1]

Cao, Y. Angiogenesis modulates adipogenesis and obesity. J. Clin. Invest. 117, 2362–2368 (2007). 10.1172/jci32239

[2]

Cao, Y. Adipose tissue angiogenesis as a therapeutic target for obesity and metabolic diseases. Nat. Rev. Drug Discov. 9, 107–115 (2010). 10.1038/nrd3055

[3]

Tisdale, M.J. Cachexia in cancer patients. Nat. Rev. Cancer 2, 862–871 (2002). 10.1038/nrc927

[4]

Chronic Peroxisome Proliferator-activated Receptor γ (PPARγ) Activation of Epididymally Derived White Adipocyte Cultures Reveals a Population of Thermogenically Competent, UCP1-containing Adipocytes Molecularly Distinct from Classic Brown Adipocytes

Natasa Petrovic, Tomas B. Waldén, Irina G. Shabalina et al.

Journal of Biological Chemistry 2010 10.1074/jbc.m109.053942

[5]

Xue, Y. et al. Hypoxia-independent angiogenesis in adipose tissues during cold acclimation. Cell Metab. 9, 99–109 (2009). 10.1016/j.cmet.2008.11.009

[6]

Nedergaard, J. & Cannon, B. The changed metabolic world with human brown adipose tissue: therapeutic visions. Cell Metab. 11, 268–272 (2010). 10.1016/j.cmet.2010.03.007

[7]

UCP1 Ablation Induces Obesity and Abolishes Diet-Induced Thermogenesis in Mice Exempt from Thermal Stress by Living at Thermoneutrality

Helena M. Feldmann, Valeria Golozoubova, Barbara Cannon et al.

Cell Metabolism 2009 10.1016/j.cmet.2008.12.014

[8]

Trayhurn, P. & Wood, I.S. Adipokines: inflammation and the pleiotropic role of white adipose tissue. Br. J. Nutr. 92, 347–355 (2004). 10.1079/bjn20041213

[9]

Lowell, B.B. et al. Development of obesity in transgenic mice after genetic ablation of brown adipose tissue. Nature 366, 740–742 (1993). 10.1038/366740a0

[10]

Xue, Y. et al. FOXC2 controls Ang-2 expression and modulates angiogenesis, vascular patterning, remodeling, and functions in adipose tissue. Proc. Natl. Acad. Sci. USA 105, 10167–10172 (2008). 10.1073/pnas.0802486105

[11]

Cederberg, A. et al. FOXC2 is a winged helix gene that counteracts obesity, hypertriglyceridemia, and diet-induced insulin resistance. Cell 106, 563–573 (2001). 10.1016/s0092-8674(01)00474-3

[12]

Furuhashi, M. et al. Adipocyte/macrophage fatty acid-binding proteins contribute to metabolic deterioration through actions in both macrophages and adipocytes in mice. J. Clin. Invest. 118, 2640–2650 (2008).

[13]

Virtanen, K.A. et al. Functional brown adipose tissue in healthy adults. N. Engl. J. Med. 360, 1518–1525 (2009). 10.1056/nejmoa0808949

[14]

Identification and Importance of Brown Adipose Tissue in Adult Humans

Aaron M. Cypess, Sanaz Lehman, Gethin Williams et al.

New England Journal of Medicine 2009 10.1056/nejmoa0810780

[15]

van Marken Lichtenbelt, W.D. et al. Cold-activated brown adipose tissue in healthy men. N. Engl. J. Med. 360, 1500–1508 (2009). 10.1056/nejmoa0808718

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194

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References

Details

Published: Mar 01, 2012
Vol/Issue: 7(3)
Pages: 606-615
License: View

Authors

Department of Microbiology, Tumor and Cell Biology, Karolinska Institute, Nobels väg 16, SE-17177 Stockholm, Sweden.

Edwin L. Steele Laboratories, Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114;

X

Xiaojuan Yang

Environmental Sciences Division and Climate Change Science Institute Oak Ridge National Laboratory Oak Ridge TN USA

Department of Microbiology, Tumor and Cell Biology, Karolinska Institute, Nobels väg 16, SE-17177 Stockholm, Sweden.; Department of Medicine and Health Sciences, Linköping University, 581 83 Linköping, Sweden.

Cite This Article

Sharon Lim, Jennifer Honek, Yuan Xue, et al. (2012). Cold-induced activation of brown adipose tissue and adipose angiogenesis in mice. Nature Protocols, 7(3), 606-615. https://doi.org/10.1038/nprot.2012.013

Cold-induced activation of brown adipose tissue and adipose angiogenesis in mice

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