Targeting cancer stem cells by inhibiting Wnt, Notch, and Hedgehog pathways

Naoko Takebe; Pamela J. Harris; Ronald Q. Warren; S. Percy Ivy

doi:10.1038/nrclinonc.2010.196

journal article Dec 14, 2010

Targeting cancer stem cells by inhibiting Wnt, Notch, and Hedgehog pathways

Naoko Takebe

Pamela J. Harris Ronald Q. Warren S. Percy Ivy

Nature Reviews Clinical Oncology Vol. 8 No. 2 pp. 97-106 · Springer Science and Business Media LLC

View at Publisher Save 10.1038/nrclinonc.2010.196

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References

137

[1]

Dick, J. E. Stem cell concepts renew cancer research. Blood 112, 4793–4807 (2008). 10.1182/blood-2008-08-077941

[2]

Dick, J. E. Looking ahead in cancer stem cell research. Nat. Biotechnol. 27, 44–46 (2009). 10.1038/nbt0109-44

[3]

Johnsen, H. E. et al. Cancer stem cells and the cellular hierarchy in haematological malignancies. Eur. J. Cancer 45 (Suppl. 1), 194–201 (2009). 10.1016/s0959-8049(09)70033-4

[4]

Odoux, C. et al. A stochastic model for cancer stem cell origin in metastatic colon cancer. Cancer Res. 68, 6932–6941 (2008). 10.1158/0008-5472.can-07-5779

[5]

Frank, N. Y., Schatton, T. & Frank, M. H. The therapeutic promise of the cancer stem cell concept. J. Clin. Invest. 120, 41–50 (2010). 10.1172/jci41004

[6]

McGovern, M., Voutev, R., Maciejowski, J., Corsi, A. K. & Hubbard, E. J. A “latent niche” mechanism for tumor initiation. Proc. Natl Acad. Sci. USA 106, 11617–11622 (2009). 10.1073/pnas.0903768106

[7]

Peacock, C. D. et al. Hedgehog signaling maintains a tumor stem cell compartment in multiple myeloma. Proc. Natl Acad. Sci. USA 104, 4048–4053 (2007). 10.1073/pnas.0611682104

[8]

Reya, T. & Clevers, H. Wnt signalling in stem cells and cancer. Nature 434, 843–850 (2005). 10.1038/nature03319

[9]

Brabletz, T., Jung, A., Spaderna, S., Hlubek, F. & Kirchner, T. Opinion: migrating cancer stem cells—an integrated concept of malignant tumour progression. Nat. Rev. Cancer 5, 744–749 (2005). 10.1038/nrc1694

[10]

Quintana, E. et al. Efficient tumour formation by single human melanoma cells. Nature 456, 593–598 (2008). 10.1038/nature07567

[11]

Dieter, S. M. et al. Distinct types of human colon cancer initiating cells contribute to primary tumor and metastasis formation [abstract 9]. Proc. Am. Assoc. Cancer Res. (2010). 10.1158/1538-7445.am10-9

[12]

Schmidt, M. et al. Polyclonal long-term repopulating stem cell clones in a primate model. Blood 100, 2737–2743 (2002). 10.1182/blood-2002-02-0407

[13]

Lapidot, T. et al. A cell initiating human acute myeloid leukaemia after transplantation into SCID mice. Nature 367, 645–648 (1994). 10.1038/367645a0

[14]

Bonnet, D. & Dick, J. E. Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell. Nat. Med. 3, 730–737 (1997). 10.1038/nm0797-730

[15]

Al-Hajj, M. et al. Prospective identification of tumorigenic breast cancer cells. Proc. Natl Acad. Sci. USA 100, 3983–3988 (2003). 10.1073/pnas.0530291100

[16]

Identification of human brain tumour initiating cells

Sheila K. Singh, Cynthia Hawkins, Ian D. Clarke et al.

Nature 2004 10.1038/nature03128

[17]

Dalerba, P. et al. Phenotypic characterization of human colorectal cancer stem cells. Proc. Natl Acad. Sci. USA 104, 10158–10163 (2007). 10.1073/pnas.0703478104

[18]

O'Brien, C. A., Pollett, A., Gallinger, S. & Dick, J. E. A human colon cancer cell capable of initiating tumour growth in immunodeficient mice. Nature 445, 106–110 (2007). 10.1038/nature05372

[19]

Ricci-Vitiani, L. et al. Identification and expansion of human colon-cancer-initiating cells. Nature 445, 111–115 (2007). 10.1038/nature05384

[20]

Prince, M. E. et al. Identification of a subpopulation of cells with cancer stem cell properties in head and neck squamous cell carcinoma. Proc. Natl Acad. Sci. USA 104, 973–978 (2007). 10.1073/pnas.0610117104

[21]

Hermann, P. C. et al. Distinct populations of cancer stem cells determine tumor growth and metastatic activity in human pancreatic cancer. Cell Stem Cell 1, 313–323 (2007). 10.1016/j.stem.2007.06.002

[22]

Li, C. et al. Identification of pancreatic cancer stem cells. Cancer Res. 67, 1030–1037 (2007). 10.1158/0008-5472.can-06-2030

[23]

Yamashita, T. et al. EpCAM-positive hepatocellular carcinoma cells are tumor-initiating cells with stem/progenitor cell features. Gastroenterology 136, 1012–1024 (2009). 10.1053/j.gastro.2008.12.004

[24]

Schatton, T. et al. Identification of cells initiating human melanomas. Nature 451, 345–349 (2008). 10.1038/nature06489

[25]

Yang, Z. F. et al. Significance of CD90+ cancer stem cells in human liver cancer. Cancer Cell 13, 153–166 (2008). 10.1016/j.ccr.2008.01.013

[26]

Bertolini, G. et al. Highly tumorigenic lung cancer CD133+ cells display stem-like features and are spared by cisplatin treatment. Proc. Natl Acad. Sci. USA 106, 16281–16286 (2009). 10.1073/pnas.0905653106

[27]

Zhang, S. et al. Identification and characterization of ovarian cancer-initiating cells from primary human tumors. Cancer Res. 68, 4311–4320 (2008). 10.1158/0008-5472.can-08-0364

[28]

Wang, X. et al. A luminal epithelial stem cell that is a cell of origin for prostate cancer. Nature 461, 495–500 (2009). 10.1038/nature08361

[29]

Chan, K. S. et al. Identification, molecular characterization, clinical prognosis, and therapeutic targeting of human bladder tumor-initiating cells. Proc. Natl Acad. Sci. USA 106, 14016–14021 (2009). 10.1073/pnas.0906549106

[30]

Suvà, M. L. et al. Identification of cancer stem cells in Ewing's sarcoma. Cancer Res. 69, 1776–1781 (2009). 10.1158/0008-5472.can-08-2242

[31]

Huang, E. H. et al. Aldehyde dehydrogenase 1 is a marker for normal and malignant human colonic stem cells (SC) and tracks SC overpopulation during colon tumorigenesis. Cancer Res. 69, 3382–3389 (2009). 10.1158/0008-5472.can-08-4418

[32]

Wang, Z. et al. Down-regulation of notch-1 inhibits invasion by inactivation of nuclear factor-kappaB, vascular endothelial growth factor, and matrix metalloproteinase-9 in pancreatic cancer cells. Cancer Res. 66, 2778–2784 (2006). 10.1158/0008-5472.can-05-4281

[33]

Krivtsov, A. V. et al. Transformation from committed progenitor to leukaemia stem cell initiated by MLL-AF9. Nature 442, 818–822 (2006). 10.1038/nature04980

[34]

Reya, T., Morrison, S. J., Clarke, M. F. & Weissman, I. L. Stem cells, cancer, and cancer stem cells. Nature 414, 105–111 (2001). 10.1038/35102167

[35]

Jamieson, C. H. et al. Granulocyte-macrophage progenitors as candidate leukemic stem cells in blast-crisis CML. N. Engl. J. Med. 351, 657–667 (2004). 10.1056/nejmoa040258

[36]

Artavanis-Tsakonas, S., Rand, M. D. & Lake, R. J. Notch signaling: cell fate control and signal integration in development. Science 284, 770–776 (1999). 10.1126/science.284.5415.770

[37]

Dontu, G. et al. Role of Notch signaling in cell-fate determination of human mammary stem/progenitor cells. Breast Cancer Res. 6, R605–R615 (2004). 10.1186/bcr920

[38]

Androutsellis-Theotokis, A. et al. Notch signalling regulates stem cell numbers in vitro and in vivo. Nature 442, 823–826 (2006). 10.1038/nature04940

[39]

Rampal, R., Arboleda-Velasquez, J. F., Nita-Lazar, A., Kosik, K. S. & Haltiwanger, R. S. Highly conserved O-fucose sites have distinct effects on Notch1 function. J. Biol. Chem. 280, 32133–32140 (2005). 10.1074/jbc.m506104200

[40]

Gordon, W. R. et al. Structural basis for autoinhibition of Notch. Nat. Struct. Mol. Biol. 14, 295–300 (2007). 10.1038/nsmb1227

[41]

Real, P. J. et al. Gamma-secretase inhibitors reverse glucocorticoid resistance in T cell acute lymphoblastic leukemia. Nat. Med. 15, 50–58 (2009). 10.1038/nm.1900

[42]

Rizzo, P. et al. Rational targeting of Notch signaling in cancer. Oncogene 27, 5124–5131 (2008). 10.1038/onc.2008.226

[43]

Duarte, A. et al. Dosage-sensitive requirement for mouse Dll4 in artery development. Genes Dev. 18, 2474–2478 (2004). 10.1101/gad.1239004

[44]

Suchting, S. et al. The Notch ligand Delta-like 4 negatively regulates endothelial tip cell formation and vessel branching. Proc. Natl Acad. Sci. USA 104, 3225–3230 (2007). 10.1073/pnas.0611177104

[45]

Ridgway, J. et al. Inhibition of Dll4 signalling inhibits tumour growth by deregulating angiogenesis. Nature 444, 1083–1087 (2006). 10.1038/nature05313

[46]

Yan, M. et al. Chronic DLL4 blockade induces vascular neoplasms. Nature 463, E6–E7 (2010). 10.1038/nature08751

[47]

Moellering, R. E. et al. Direct inhibition of the NOTCH transcription factor complex. Nature 462, 182–188 (2009). 10.1038/nature08543

[48]

Sawyer, T. K. AILERON Therapeutics. Chem. Biol. Drug Des. 73, 3–6 (2009). 10.1111/j.1747-0285.2008.00744.x

[49]

Epenetos, A., Kousparou, C. & Stylianou, S. Inhibition of Notch signaling for the treatment of human carcinomas. AACR Meeting Abstracts A5502 (2009).

[50]

Wu, Y. et al. Therapeutic antibody targeting of individual Notch receptors. Nature 464, 1052–1057 (2010). 10.1038/nature08878

Showing 50 of 137 references

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Published: Dec 14, 2010
Vol/Issue: 8(2)
Pages: 97-106
License: View

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Cite This Article

Naoko Takebe, Pamela J. Harris, Ronald Q. Warren, et al. (2010). Targeting cancer stem cells by inhibiting Wnt, Notch, and Hedgehog pathways. Nature Reviews Clinical Oncology, 8(2), 97-106. https://doi.org/10.1038/nrclinonc.2010.196

Targeting cancer stem cells by inhibiting Wnt, Notch, and Hedgehog pathways

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