Mechanisms of type-I- and type-II-interferon-mediated signalling

Leonidas C. Platanias

doi:10.1038/nri1604

journal article May 01, 2005

Mechanisms of type-I- and type-II-interferon-mediated signalling

Leonidas C. Platanias

Nature Reviews Immunology Vol. 5 No. 5 pp. 375-386 · Springer Science and Business Media LLC

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References

138

[1]

Pestka, S., Langer, J. A., Zoon, K. C. & Samuel, C. E. Interferons and their actions. Annu. Rev. Biochem. 56, 727–777 (1987). 10.1146/annurev.bi.56.070187.003455

[2]

Pestka, S., Krause, C. D. & Walter, M. R. Interferons, interferon-like cytokines, and their receptors. Immunol. Rev. 202, 8–32 (2004). 10.1111/j.0105-2896.2004.00204.x

[3]

Pestka, S. The human interferon α species and hybrid proteins. Semin. Oncol. 24, S9-4–S9-17 (1997).

[4]

Chen, J., Baig, E. & Fish, E. N. Diversity and relatedness among the type I interferons. J. Interfon Cytokine Res. 24, 687–698 (2004). 10.1089/jir.2004.24.687

[5]

Platanias, L. C. & Fish, E. N. Signaling pathways activated by interferons. Exp. Hematol. 27, 1583–1592 (1999). 10.1016/s0301-472x(99)00109-5

[6]

Parmar, S. & Platanias, L. C. Interferons: mechanisms of action and clinical applications. Curr. Opin. Oncol. 15, 431–439 (2003). 10.1097/00001622-200311000-00005

[7]

Pestka, S. et al. The interferon γ (IFN-γ) receptor: a paradigm for the multichain cytokine receptor. Cytokine Growth Factor Rev. 8, 189–206 (1997). 10.1016/s1359-6101(97)00009-9

[8]

Bach, E. A., Aguet, M. & Schreiber, R. D. The IFN γ receptor: a paradigm for cytokine receptor signaling. Annu. Rev. Immunol. 15, 563–591 (1997). 10.1146/annurev.immunol.15.1.563

[9]

Isaacs, A. & Lindenmann, J. Virus interference. I. The interferon. Proc. R. Soc. Lond. B 147, 258–267 (1957). 10.1098/rspb.1957.0048

[10]

Kotenko, S. V. et al. IFN-λs mediate antiviral protection through a distinct class II cytokine receptor complex. Nature Immunol. 4, 69–77 (2003). 10.1038/ni875

[11]

Jak-STAT Pathways and Transcriptional Activation in Response to IFNs and Other Extracellular Signaling Proteins

James E. Darnell, lan M. Kerr, George R. Stark

Science 1994 10.1126/science.8197455

[12]

Ihle, J. N. The Janus protein tyrosine kinase family and its role in cytokine signaling. Adv. Immunol. 60, 1–35 (1995). 10.1016/s0065-2776(08)60582-9

[13]

Platanias, L. C. The p38 mitogen-activated protein kinase pathway and its role in interferon signaling. Pharmacol. Ther. 98, 129–142 (2003). 10.1016/s0163-7258(03)00016-0

[14]

Der, S. D., Zhou, A., Williams, B. R. & Silverman, R. H. Identification of genes differentially regulated by interferon α, β, or γ using oligonucleotide arrays. Proc. Natl Acad. Sci. USA 95, 15623–15628 (1998). 10.1073/pnas.95.26.15623

[15]

Schindler, C., Shuai, K., Prezioso, V. R. & Darnell, J. E. Interferon-dependent tyrosine phosphorylation of a latent cytoplasmic transcription factor. Science 257, 809–813 (1992). 10.1126/science.1496401

[16]

The proteins of ISGF-3, the interferon alpha-induced transcriptional activator, define a gene family involved in signal transduction.

X Y Fu, C Schindler, T Improta et al.

Proceedings of the National Academy of Sciences 1992 10.1073/pnas.89.16.7840

[17]

Shuai, K., Schindler, C., Prezioso, V. R. & Darnell, J. E. Activation of transcription by IFN-γ: tyrosine phosphorylation of a 91-kD DNA binding protein. Science 258, 1808–1812 (1992). 10.1126/science.1281555

[18]

Silvennoinen, O., Ihle, J. N., Schlessinger, J. & Levy, D. E. Interferon-induced nuclear signaling by Jak protein tyrosine kinases. Nature 366, 583–585 (1993). 10.1038/366583a0

[19]

Stark, G. R., Kerr, I. M., Williams, B. R. G., Silverman, R. H. & Schreiber, R. D. How cells respond to interferons. Annu. Rev. Biochem. 67, 227–264 (1998). 10.1146/annurev.biochem.67.1.227

[20]

Darnell, J. E. Stats and gene regulation. Science 277, 1630–1635 (1997). An excellent review of the mechanisms of STAT activation and the regulatory effects of STATs on gene transcription. 10.1126/science.277.5332.1630

[21]

Aaronson, D. S. & Horvath C. M. A road map for those who don't know JAK–STAT. Science 296, 1653–1655 (2002). 10.1126/science.1071545

[22]

Meinke, A., Barahmand-Pour, F., Wohrl, S., Stoiber, D. & Decker, T. Activation of different Stat5 isoforms contributes to cell-type-restricted signaling in response to interferons. Mol. Cell. Biol. 16, 6937–6944 (1996). 10.1128/mcb.16.12.6937

[23]

Farrar, J. D., Smith, J. D., Murphy, T. L. & Murphy, K. M. Recruitment of Stat4 to the human interferon-α/β receptor requires activated Stat2. J. Biol. Chem. 275, 2693–2697 (2000). 10.1074/jbc.275.4.2693

[24]

Torpey, N., Maher, S. E., Bothwell, A. L. & Pober, J. S. Interferon α but not interleukin 12 activates STAT4 signaling in human vascular endothelial cells. J. Biol. Chem. 279, 26789–26796 (2004). 10.1074/jbc.m401517200

[25]

Matikainen, S. et al. Interferon-α activates multiple STAT proteins and upregulates proliferation-associated IL-2Rα, c-myc, and pim-1 genes in human T cells. Blood 93, 1980–1991 (1999). 10.1182/blood.v93.6.1980.406k20_1980_1991

[26]

Fasler-Kan, E., Pansky, A., Wiederkehr, M., Battegay, M. & Heim, M. H. Interferon-α activates signal transducers and activators of transcription 5 and 6 in Daudi cells. Eur. J. Biochem. 254, 514–519 (1998). 10.1046/j.1432-1327.1998.2540514.x

[27]

Nguyen, K. B. et al. Critical role for STAT4 activation by type 1 interferons in the interferon-γ response to viral infection. Science 297, 2063–2066 (2002). 10.1126/science.1074900

[28]

Boehm, U., Klamp, T., Groot, M. & Howard, J. C. Cellular responses to interferon-γ. Annu. Rev. Immunol. 15, 749–795 (1997). 10.1146/annurev.immunol.15.1.749

[29]

Wen, Z., Zhong, Z. & Darnell, J. E. Maximal activation of transcription by Stat1 and Stat3 requires both tyrosine and serine phosphorylation. Cell 82, 241–250 (1995). 10.1016/0092-8674(95)90311-9

[30]

Wen, Z. & Darnell, J. E. Mapping of Stat3 serine phosphorylation to a single residue (727) and evidence that serine phosphorylation has no influence on DNA binding of Stat1 and Stat3. Nucleic Acids Res. 25, 2062–2067 (1997). 10.1093/nar/25.11.2062

[31]

Varinou, L. et al. Phosphorylation of the Stat1 transactivation domain is required for full-fledged IFN-γ-dependent innate immunity. Immunity 19, 793–802 (2003). 10.1016/s1074-7613(03)00322-4

[32]

Uddin, S. et al. Protein kinase C-δ (PKC-δ) is activated by type I interferons and mediates phosphorylation of Stat1 on serine 727. J. Biol. Chem. 277, 14408–14416 (2002). The first identification of PKC-δ as an IFN-activated kinase that regulates the phosphorylation of STAT1 on Ser727. 10.1074/jbc.m109671200

[33]

Deb, D. K. et al. Activation of protein kinase C δ by IFN-γ. J. Immunol. 171, 267–273 (2003). 10.4049/jimmunol.171.1.267

[34]

Kristof, A. S., Marks-Konczalik, J., Billings, E. & Moss, J. Stimulation of signal transducer and activator of transcription-1 (STAT1)-dependent gene transcription by lipopolysaccharide and interferon-γ is regulated by mammalian target of rapamycin. J. Biol. Chem. 278, 33637–33644 (2003). 10.1074/jbc.m301053200

[35]

Choudhury, G. G. A linear signal transduction pathway involving phosphatidylinositol 3-kinase, protein kinase C-ε, and MAPK in mesangial cells regulates interferon-γ-induced STAT1α transcriptional activation. J. Biol. Chem. 279, 27399–27409 (2004). 10.1074/jbc.m403530200

[36]

Nair, J. S. et al. Requirement of Ca2+ and CaMKII for Stat1 Ser-727 phosphorylation in response to IFN-γ. Proc. Natl Acad. Sci. USA 99, 5971–5976 (2002). 10.1073/pnas.052159099

[37]

Zhang, J. J. et al. Two contact regions between Stat1 and CBP/p300 in interferon γ signaling. Proc. Natl Acad. Sci. USA 93, 15092–15096 (1996). 10.1073/pnas.93.26.15092

[38]

Bhattacharya, S. et al. Cooperation of Stat2 and p300/CBP in signaling induced by interferon-α. Nature 383, 344–347 (1996). 10.1038/383344a0

[39]

Zhang, J. J. et al. Ser727-dependent recruitment of MCM5 by Stat1α in IFN-γ-induced transcriptional activation. EMBO J. 17, 6963–6971 (1998). 10.1093/emboj/17.23.6963

[40]

DaFonseca, C. J., Shu, F. & Zhang, J. J. Identification of two residues in MCM5 critical for the assembly of MCM complexes and Stat1-mediated transcription activation in response to IFN-γ. Proc. Natl Acad. Sci. USA 98, 3034–3039 (2001). 10.1073/pnas.061487598

[41]

Hebbes, T. R., Thorne, A. W. & Crane-Robinson, C. A direct link between core histone acetylation and transcriptionally active chromatin. EMBO J. 7, 1395–1402 (1988). 10.1002/j.1460-2075.1988.tb02956.x

[42]

Paulson, M., Press, C., Smith, E., Tanese, E. & Levy, D. E. IFN-stimulated transcription through a TBP- free acetyltransferase complex escapes viral shutoff. Nature Cell Biol. 4, 140–147 (2002). 10.1038/ncb747

[43]

Huang, M. et al. Chromatin-remodelling factor BRG1 selectively activates a subset of interferon-α-inducible genes. Nature Cell Biol. 4, 774–781 (2002). 10.1038/ncb855

[44]

Zhu, M., John, S., Berg, M. & Leonard, W. J. Functional association of Nmi with Stat5 and Stat1 in IL-2- and IFNγ-mediated signaling. Cell 96, 121–130 (1999). 10.1016/s0092-8674(00)80965-4

[45]

Nusinzon, I. & Horvath, C. M. Interferon-stimulated transcription and innate antiviral immunity require deacetylase activity and histone deacetylase 1. Proc. Natl Acad. Sci. USA 100, 14742–14747 (2003). The first evidence that histone-deacetylase activity is required for IFN-dependent transcription. 10.1073/pnas.2433987100

[46]

Chang, H. M. et al. Induction of interferon-stimulated gene expression and antiviral responses require protein deacetylase activity. Proc. Natl Acad. Sci. USA 101, 9578–9583 (2004). 10.1073/pnas.0400567101

[47]

Sakamoto, S., Potla, R. & Larner, A. C. Histone deacetylase activity is required to recruit RNA polymerase II to the promoters of selected interferon-stimulated early response genes. J. Biol. Chem. 279, 40362–40367 (2004). 10.1074/jbc.m406400200

[48]

Mayer, B. J., Hamaguchi, M. & Hanafusa, H. A novel viral oncogene with structural homology to phospholipase C. Nature 332, 272–275 (1988). 10.1038/332272a0

[49]

Feller, S. M. Crk family adaptors — signaling complex formation and biological roles. Oncogene 20, 6348–6371 (2001). 10.1038/sj.onc.1204779

[50]

Ahmad, S., Alsayed, Y., Druker, B. J. & Platanias, L. C. The type I interferon receptor mediates tyrosine phosphorylation of the CrkL adaptor protein. J. Biol. Chem. 272, 29991–29994 (1997). 10.1074/jbc.272.48.29991

Showing 50 of 138 references

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Published: May 01, 2005
Vol/Issue: 5(5)
Pages: 375-386
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Leonidas C. Platanias

Cite This Article

Leonidas C. Platanias (2005). Mechanisms of type-I- and type-II-interferon-mediated signalling. Nature Reviews Immunology, 5(5), 375-386. https://doi.org/10.1038/nri1604

Mechanisms of type-I- and type-II-interferon-mediated signalling

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