Topics

No keywords indexed for this article. Browse by subject →

References
201
[1]
Qian, B. Z. & Pollard, J. W. Macrophage diversity enhances tumor progression and metastasis. Cell 141, 39–51 (2010). 10.1016/j.cell.2010.03.014
[2]
Biswas, S. K. & Mantovani, A. Macrophage plasticity and interaction with lymphocyte subsets: cancer as a paradigm. Nature Immunol. 11, 889–896 (2010). 10.1038/ni.1937
[3]
Coussens, L. M. & Pollard, J. W. Leukocytes in mammary development and cancer. Cold Spring Harb. Perspect. Biol. 3, a003285 (2011). 10.1101/cshperspect.a003285
[4]
Khazaie, K. et al. The significant role of mast cells in cancer. Cancer Metastasis Rev. 30, 45–60 (2011). 10.1007/s10555-011-9286-z
[5]
Liu, K. & Nussenzweig, M. C. Origin and development of dendritic cells. Immunol. Rev. 234, 45–54 (2010). 10.1111/j.0105-2896.2009.00879.x
[6]
Fogg, D. K. et al. A clonogenic bone marrow progenitor specific for macrophages and dendritic cells. Science 311, 83–87 (2006). 10.1126/science.1117729
[7]
Onai, N. et al. Identification of clonogenic common Flt3+M-CSFR+ plasmacytoid and conventional dendritic cell progenitors in mouse bone marrow. Nature Immunol. 8, 1207–1216 (2007). 10.1038/ni1518
[8]
Naik, S. H. et al. Development of plasmacytoid and conventional dendritic cell subtypes from single precursor cells derived in vitro and in vivo. Nature Immunol. 8, 1217–1226 (2007). 10.1038/ni1522
[9]
Shortman, K. & Heath, W. R. The CD8+ dendritic cell subset. Immunol. Rev. 234, 18–31 (2010). 10.1111/j.0105-2896.2009.00870.x
[10]
Idoyaga, J. & Steinman, R. M. SnapShot: dendritic cells. Cell 146, 660–660.e2 (2011). 10.1016/j.cell.2011.08.010
[11]
Swiecki, M. & Colonna, M. Unraveling the functions of plasmacytoid dendritic cells during viral infections, autoimmunity, and tolerance. Immunol. Rev. 234, 142–162 (2010). 10.1111/j.0105-2896.2009.00881.x
[12]
Dominguez, P. M. & Ardavin, C. Differentiation and function of mouse monocyte-derived dendritic cells in steady state and inflammation. Immunol. Rev. 234, 90–104 (2010). 10.1111/j.0105-2896.2009.00876.x
[13]
Gabrilovich, D. I. The mechanisms and functional significance of tumour-induced dendritic-cell defects. Nature Rev. Immunol. 4, 941–952 (2004). 10.1038/nri1498
[14]
Pinzon-Charry, A. et al. Numerical and functional defects of blood dendritic cells in early- and late-stage breast cancer. Br. J. Cancer 97, 1251–1259 (2007). 10.1038/sj.bjc.6604018
[15]
Perrot, I. et al. Dendritic cells infiltrating human non-small cell lung cancer are blocked at immature stage. J. Immunol. 178, 2763–2769 (2007). 10.4049/jimmunol.178.5.2763
[16]
Bellone, G. et al. Cooperative induction of a tolerogenic dendritic cell phenotype by cytokines secreted by pancreatic carcinoma cells. J. Immunol. 177, 3448–3460 (2006). 10.4049/jimmunol.177.5.3448
[17]
Lee, B. N. et al. Deficiencies in myeloid antigen-presenting cells in women with cervical squamous intraepithelial lesions. Cancer 107, 999–1007 (2006). 10.1002/cncr.22092
[18]
Ormandy, L. A. et al. Direct ex vivo analysis of dendritic cells in patients with hepatocellular carcinoma. World J. Gastroenterol. 12, 3275–3282 (2006). 10.3748/wjg.v12.i20.3275
[19]
Pinzon-Charry, A., Maxwell, T. & Lopez, J. A. Dendritic cell dysfunction in cancer: a mechanism for immunosuppression. Immunol. Cell Biol. 83, 451–461 (2005). 10.1111/j.1440-1711.2005.01371.x
[20]
Mancino, A. et al. Divergent effects of hypoxia on dendritic cell functions. Blood 112, 3723–3734 (2008). 10.1182/blood-2008-02-142091
[21]
Elia, A. R. et al. Human dendritic cells differentiated in hypoxia down-modulate antigen uptake and change their chemokine expression profile. J. Leukoc. Biol. 84, 1472–1482 (2008). 10.1189/jlb.0208082
[22]
Yang, M. et al. HIF-dependent induction of adenosine receptor A2b skews human dendritic cells to a Th2-stimulating phenotype under hypoxia. Immunol. Cell Biol. 88, 165–171 (2010). 10.1038/icb.2009.77
[23]
Novitskiy, S. V. et al. Adenosine receptors in regulation of dendritic cell differentiation and function. Blood 112, 1822–1831 (2008). 10.1182/blood-2008-02-136325
[24]
Gottfried, E. et al. Tumor-derived lactic acid modulates dendritic cell activation and antigen expression. Blood 107, 2013–2021 (2006). 10.1182/blood-2005-05-1795
[25]
Herber, D. L. et al. Lipid accumulation and dendritic cell dysfunction in cancer. Nature Med. 16, 880–886 (2010). 10.1038/nm.2172
[26]
Ghiringhelli, F. et al. Tumor cells convert immature myeloid dendritic cells into TGF-β-secreting cells inducing CD4+CD25+ regulatory T cell proliferation. J. Exp. Med. 202, 919–929 (2005). 10.1084/jem.20050463
[27]
Lin, A., Schildknecht, A., Nguyen, L. T. & Ohashi, P. S. Dendritic cells integrate signals from the tumor microenvironment to modulate immunity and tumor growth. Immunol. Lett. 127, 77–84 (2010). 10.1016/j.imlet.2009.09.003
[28]
Norian, L. A. et al. Tumor-infiltrating regulatory dendritic cells inhibit CD8+ T cell function via L-arginine metabolism. Cancer Res. 69, 3086–3094 (2009). 10.1158/0008-5472.can-08-2826
[29]
Watkins, S. K. et al. FOXO3 programs tumor-associated DCs to become tolerogenic in human and murine prostate cancer. J. Clin. Invest. 121, 1361–1372 (2011). 10.1172/jci44325
[30]
Dumitriu, I. E., Dunbar, D. R., Howie, S. E., Sethi, T. & Gregory, C. D. Human dendritic cells produce TGF-β1 under the influence of lung carcinoma cells and prime the differentiation of CD4+CD25+Foxp3+ regulatory T cells. J. Immunol. 182, 2795–2807 (2009). 10.4049/jimmunol.0712671
[31]
Liu, Q. et al. Tumor-educated CD11bhighIalow regulatory dendritic cells suppress T cell response through arginase I. J. Immunol. 182, 6207–6216 (2009). 10.4049/jimmunol.0803926
[32]
Lee, J. R. et al. Pattern of recruitment of immunoregulatory antigen-presenting cells in malignant melanoma. Lab. Invest. 83, 1457–1466 (2003). 10.1097/01.lab.0000090158.68852.d1
[33]
Munn, D. H. et al. Expression of indoleamine 2,3-dioxygenase by plasmacytoid dendritic cells in tumor-draining lymph nodes. J. Clin. Invest. 114, 280–290 (2004). 10.1172/jci21583
[34]
Baban, B. et al. IDO activates regulatory T cells and blocks their conversion into Th17-like T cells. J. Immunol. 183, 2475–2483 (2009). 10.4049/jimmunol.0900986
[35]
Mosser, D. M. & Edwards, J. P. Exploring the full spectrum of macrophage activation. Nature Rev. Immunol. 8, 958–969 (2008). 10.1038/nri2448
[36]
Macrophage polarization: tumor-associated macrophages as a paradigm for polarized M2 mononuclear phagocytes

A MANTOVANI, S SOZZANI, M LOCATI et al.

Trends in Immunology 2002 10.1016/s1471-4906(02)02302-5
[37]
Mantovani, A., Sica, A., Allavena, P., Garlanda, C. & Locati, M. Tumor-associated macrophages and the related myeloid-derived suppressor cells as a paradigm of the diversity of macrophage activation. Hum. Immunol. 70, 325–330 (2009). 10.1016/j.humimm.2009.02.008
[38]
Mantovani, A. & Sica, A. Macrophages, innate immunity and cancer: balance, tolerance, and diversity. Curr. Opin. Immunol. 22, 231–237 (2010). 10.1016/j.coi.2010.01.009
[39]
Steidl, C. et al. Tumor-associated macrophages and survival in classic Hodgkin's lymphoma. N. Engl. J. Med. 362, 875–885 (2010). This study identified a gene signature of TAMs that was associated with primary treatment failure in patients with Hodgkin's lymphoma, and demonstrated that the number of macrophages in patients with Hodgkin's lymphoma is prognostic of clinical outcome. 10.1056/nejmoa0905680
[40]
Lin, E. Y. et al. Macrophages regulate the angiogenic switch in a mouse model of breast cancer. Cancer Res. 66, 11238–11246 (2006). 10.1158/0008-5472.can-06-1278
[41]
Qian, B. et al. A distinct macrophage population mediates metastatic breast cancer cell extravasation, establishment and growth. PLoS ONE 4, e6562 (2009). This study demonstrated that macrophages have a crucial role in metastatic cell seeding and in the progression of metastatic disease. 10.1371/journal.pone.0006562
[42]
Zheng, Y. et al. Macrophages are an abundant component of myeloma microenvironment and protect myeloma cells from chemotherapy drug-induced apoptosis. Blood 114, 3625–3628 (2009). 10.1182/blood-2009-05-220285
[43]
Alternative Activation of Macrophages: Mechanism and Functions

Siamon Gordon, Fernando O. Martinez

Immunity 2010 10.1016/j.immuni.2010.05.007
[44]
DeNardo, D. G. et al. CD4+ T cells regulate pulmonary metastasis of mammary carcinomas by enhancing protumor properties of macrophages. Cancer Cell 16, 91–102 (2009). This study demonstrated that, in transgenic mice with mammary carcinomas, TAMs develop a pro-tumour and pro-metastatic phenotype in response to CD4+ T cell-derived IL-4. These findings demonstrate that the adaptive immune system plays a substantial part in driving the pro-tumour activity of the innate immune system. 10.1016/j.ccr.2009.06.018
[45]
Murai, M. et al. Interleukin 10 acts on regulatory T cells to maintain expression of the transcription factor Foxp3 and suppressive function in mice with colitis. Nature Immunol. 10, 1178–1184 (2009). 10.1038/ni.1791
[46]
Curiel, T. J. et al. Specific recruitment of regulatory T cells in ovarian carcinoma fosters immune privilege and predicts reduced survival. Nature Med. 10, 942–949 (2004). 10.1038/nm1093
[47]
Torroella-Kouri, M. et al. Identification of a subpopulation of macrophages in mammary tumor-bearing mice that are neither M1 nor M2 and are less differentiated. Cancer Res. 69, 4800–4809 (2009). 10.1158/0008-5472.can-08-3427
[48]
Kuang, D. M. et al. Activated monocytes in peritumoral stroma of hepatocellular carcinoma foster immune privilege and disease progression through PD-L1. J. Exp. Med. 206, 1327–1337 (2009). This study demonstrated that CD68+ monocytes in the peritumoural stroma of patients with hepatocellular carcinoma express PDL1, induce T cell anergy, promote tumour progression and are associated with poor survival. 10.1084/jem.20082173
[49]
Rodriguez, P. C. et al. Arginase I production in the tumor microenvironment by mature myeloid cells inhibits T-cell receptor expression and antigen-specific T-cell responses. Cancer Res. 64, 5839–5849 (2004). 10.1158/0008-5472.can-04-0465
[50]
CCL2 recruits inflammatory monocytes to facilitate breast-tumour metastasis

Bin-Zhi Qian, Jiufeng Li, Hong Zhang et al.

Nature 2011 10.1038/nature10138

Showing 50 of 201 references

Cited By
3,098
Autoimmunity Reviews
International Journal of Surgery
Frontiers in Immunology
Trends in Cancer
Myeloid-derived suppressor cells in cancer and cancer therapy

Samantha A. Lasser, Feyza G. Ozbay Kurt · 2024

Nature Reviews Clinical Oncology
Cell Biology International
International Journal of Molecular...
Journal of Hematology & Oncolog...
Metrics
3,098
Citations
201
References
Details
Published
Mar 22, 2012
Vol/Issue
12(4)
Pages
253-268
License
View
Cite This Article
Dmitry I. Gabrilovich, Suzanne Ostrand-Rosenberg, Vincenzo Bronte (2012). Coordinated regulation of myeloid cells by tumours. Nature Reviews Immunology, 12(4), 253-268. https://doi.org/10.1038/nri3175
Related

You May Also Like

Exploring the full spectrum of macrophage activation

David M. Mosser, Justin P. Edwards · 2008

7,678 citations

Toll-like receptor signalling

Shizuo Akira, Kiyoshi Takeda · 2004

6,704 citations

Myeloid-derived suppressor cells as regulators of the immune system

Dmitry I. Gabrilovich, Srinivas Nagaraj · 2009

5,769 citations

Sex differences in immune responses

Sabra L. Klein, Katie L. Flanagan · 2016

5,281 citations

Alternative activation of macrophages

Siamon Gordon · 2003

4,808 citations