journal article Sep 01, 2007

The role of nuclear architecture in genomic instability and ageing

Topics

No keywords indexed for this article. Browse by subject →

References
86
[1]
Cheutin, T. et al. Maintenance of stable heterochromatin domains by dynamic HP1 binding. Science 299, 721–725 (2003). 10.1126/science.1078572
[2]
Grewal, S. I. & Jia, S. Heterochromatin revisited. Nature Rev. Genet. 8, 35–46 (2007). 10.1038/nrg2008
[3]
Obe, G. et al. Chromosomal aberrations: formation, identification and distribution. Mutat. Res. 504, 17–36 (2002). 10.1016/s0027-5107(02)00076-3
[4]
Villeponteau, B. The heterochromatin loss model of aging. Exp. Gerontol. 32, 383–394 (1997). 10.1016/s0531-5565(96)00155-6
[5]
Imai, S. & Kitano, H. Heterochromatin islands and their dynamic reorganization: a hypothesis for three distinctive features of cellular aging. Exp. Gerontol. 33, 555–570 (1998). 10.1016/s0531-5565(98)00037-0
[6]
Goldstein, S. Replicative senescence: the human fibroblast comes of age. Science 249, 1129–1133 (1990). 10.1126/science.2204114
[7]
Campisi, J. Senescent cells, tumor suppression, and organismal aging: good citizens, bad neighbors. Cell 120, 513–522 (2005). 10.1016/j.cell.2005.02.003
[8]
Kennedy, B. K. et al. Redistribution of silencing proteins from telomeres to the nucleolus is associated with extension of life span in S. cerevisiae. Cell 89, 381–391 (1997). 10.1016/s0092-8674(00)80219-6
[9]
Sinclair, D. A. & Guarente, L. Extrachromosomal rDNA circles — a cause of aging in yeast. Cell 91, 1033–1042 (1997). 10.1016/s0092-8674(00)80493-6
[10]
Chakalova, L., Debrand, E., Mitchell, J. A., Osborne, C. S. & Fraser, P. Replication and transcription: shaping the landscape of the genome. Nature Rev. Genet. 6, 669–677 (2005). 10.1038/nrg1673
[11]
Hennekam, R. C. Hutchinson–Gilford progeria syndrome: review of the phenotype. Am. J. Med. Genet. A 140, 2603–2624 (2006). 10.1002/ajmg.a.31346
[12]
Narita, M. et al. Rb-mediated heterochromatin formation and silencing of E2F target genes during cellular senescence. Cell 113, 703–716 (2003). Describes how cellular senescence leads to the formation of facultative heterochromatic foci, which alter the nuclear architecture. Alterations in nuclear architecture change the expression of cell-cycle regulators and can cause cell-cycle arrest. 10.1016/s0092-8674(03)00401-x
[13]
Scaffidi, P. & Misteli, T. Lamin A-dependent nuclear defects in human aging. Science 312, 1059–1063 (2006). Implicates the main cause of HGPS — a defective lamin A splice variant — in normal human ageing. 10.1126/science.1127168
[14]
Sinclair, D. A., Mills, K. & Guarente, L. Molecular mechanisms of yeast aging. Trends Biochem. Sci. 23, 131–134 (1998). 10.1016/s0968-0004(98)01188-8
[15]
Imai, S., Armstrong, C. M., Kaeberlein, M. & Guarente, L. Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase. Nature 403, 795–800 (2000). 10.1038/35001622
[16]
Kaeberlein, M., McVey, M. & Guarente, L. The SIR2/3/4 complex and SIR2 alone promote longevity in Saccharomyces cerevisiae by two different mechanisms. Genes Dev. 13, 2570–2580 (1999). 10.1101/gad.13.19.2570
[17]
Straight, A. F. et al. Net1, a Sir2-associated nucleolar protein required for rDNA silencing and nucleolar integrity. Cell 97, 245–256 (1999). 10.1016/s0092-8674(00)80734-5
[18]
Shou, W. et al. Exit from mitosis is triggered by Tem1-dependent release of the protein phosphatase Cdc14 from nucleolar RENT complex. Cell 97, 233–244 (1999). 10.1016/s0092-8674(00)80733-3
[19]
Visintin, R. et al. The phosphatase Cdc14 triggers mitotic exit by reversal of Cdk-dependent phosphorylation. Mol. Cell 2, 709–718 (1998). 10.1016/s1097-2765(00)80286-5
[20]
Kennedy, B. K., Austriaco, N. R., Jr, Zhang, J. & Guarente, L. Mutation in the silencing gene SIR4 can delay aging in S. cerevisiae. Cell 80, 485–496 (1995). 10.1016/0092-8674(95)90499-9
[21]
Watt, P. M., Louis, E. J., Borts, R. H. & Hickson, I. D. Sgs1: a eukaryotic homolog of E. coli RecQ that interacts with topoisomerase II in vivo and is required for faithful chromosome segregation. Cell 81, 253–260 (1995). 10.1016/0092-8674(95)90335-6
[22]
Yu, C. E. et al. Positional cloning of the Werner's syndrome gene. Science 272, 258–262 (1996). 10.1126/science.272.5259.258
[23]
Sinclair, D. A., Mills, K. & Guarente, L. Accelerated aging and nucleolar fragmentation in yeast sgs1 mutants. Science 277, 1313–1316 (1997). 10.1126/science.277.5330.1313
[24]
McAinsh, A. D., Scott-Drew, S., Murray, J. A. & Jackson, S. P. DNA damage triggers disruption of telomeric silencing and Mec1p-dependent relocation of Sir3p. Curr. Biol. 9, 963–966 (1999). 10.1016/s0960-9822(99)80424-2
[25]
Mills, K. D., Sinclair, D. A. & Guarente, L. MEC1-dependent redistribution of the Sir3 silencing protein from telomeres to DNA double-strand breaks. Cell 97, 609–620 (1999). 10.1016/s0092-8674(00)80772-2
[26]
Lee, S. E., Paques, F., Sylvan, J. & Haber, J. E. Role of yeast SIR genes and mating type in directing DNA double-strand breaks to homologous and non-homologous repair paths. Curr. Biol. 9, 767–770 (1999). 10.1016/s0960-9822(99)80339-x
[27]
Martin, S. G., Laroche, T., Suka, N., Grunstein, M. & Gasser, S. M. Relocalization of telomeric Ku and SIR proteins in response to DNA strand breaks in yeast. Cell 97, 621–633 (1999). References 25 and 27 show that DNA damage triggers the relocalization of the yeast Sir-silencing complex to sites of DNA breaks and causes nuclear changes that are reminiscent of normal ageing in yeast. 10.1016/s0092-8674(00)80773-4
[28]
Tamburini, B. A. & Tyler, J. K. Localized histone acetylation and deacetylation triggered by the homologous recombination pathway of double-strand DNA repair. Mol. Cell. Biol. 25, 4903–4913 (2005). 10.1128/mcb.25.12.4903-4913.2005
[29]
McMurray, M. A. & Gottschling, D. E. An age-induced switch to a hyper-recombinational state. Science 301, 1908–1911 (2003). 10.1126/science.1087706
[30]
Eriksson, M. et al. Recurrent de novo point mutations in lamin A cause Hutchinson–Gilford progeria syndrome. Nature 423, 293–298 (2003). 10.1038/nature01629
[31]
Scaffidi, P. & Misteli, T. Reversal of the cellular phenotype in the premature aging disease Hutchinson–Gilford progeria syndrome. Nature Med. 11, 440–445 (2005). 10.1038/nm1204
[32]
Haithcock, E. et al. Age-related changes of nuclear architecture in Caenorhabditis elegans. Proc. Natl Acad. Sci. USA 102, 16690–16695 (2005). 10.1073/pnas.0506955102
[33]
Shiloh, Y. Ataxia-telangiectasia: closer to unraveling the mystery. Eur. J. Hum. Genet. 3, 116–138 (1995). 10.1159/000472285
[34]
Smilenov, L. B. et al. Influence of ATM function on telomere metabolism. Oncogene 15, 2659–2665 (1997). 10.1038/sj.onc.1201449
[35]
Verdun, R. E. & Karlseder, J. The DNA damage machinery and homologous recombination pathway act consecutively to protect human telomeres. Cell 127, 709–720 (2006). 10.1016/j.cell.2006.09.034
[36]
Greenwell, P. W. et al. TEL1, a gene involved in controlling telomere length in S. cerevisiae, is homologous to the human ataxia telangiectasia gene. Cell 82, 823–829 (1995). 10.1016/0092-8674(95)90479-4
[37]
Gaubatz, J. W. & Cutler, R. G. Mouse satellite DNA is transcribed in senescent cardiac muscle. J. Biol. Chem. 265, 17753–17758 (1990). 10.1016/s0021-9258(18)38227-9
[38]
Shen, S., Liu, A., Li, J., Wolubah, C. & Casaccia-Bonnefil, P. Epigenetic memory loss in aging oligodendrocytes in the corpus callosum. Neurobiol. Aging 19 December 2006 (doi:10.1016/j.neurobiolaging.2006.10.026). 10.1016/j.neurobiolaging.2006.10.026
[39]
Imai, S. et al. Dissociation of Oct-1 from the nuclear peripheral structure induces the cellular aging-associated collagenase gene expression. Mol. Biol. Cell 8, 2407–2419 (1997). 10.1091/mbc.8.12.2407
[40]
Formation of MacroH2A-Containing Senescence-Associated Heterochromatin Foci and Senescence Driven by ASF1a and HIRA

Rugang Zhang, Maxim V. Poustovoitov, Xiaofen Ye et al.

Developmental Cell 2005 10.1016/j.devcel.2004.10.019
[41]
Dellaire, G. & Bazett-Jones, D. P. PML nuclear bodies: dynamic sensors of DNA damage and cellular stress. Bioessays 26, 963–977 (2004). 10.1002/bies.20089
[42]
Herbig, U., Ferreira, M., Condel, L., Carey, D. & Sedivy, J. M. Cellular senescence in aging primates. Science 311, 1257 (2006). 10.1126/science.1122446
[43]
Lu, T. et al. Gene regulation and DNA damage in the ageing human brain. Nature 429, 883–891 (2004). Gene-expression profiling reveals DNA-damage-induced global gene repression in the ageing brain. 10.1038/nature02661
[44]
Lee, C. K., Weindruch, R. & Prolla, T. A. Gene-expression profile of the ageing brain in mice. Nature Genet. 25, 294–297 (2000). 10.1038/77046
[45]
Lee, C. K., Klopp, R. G., Weindruch, R. & Prolla, T. A. Gene expression profile of aging and its retardation by caloric restriction. Science 285, 1390–1393 (1999). 10.1126/science.285.5432.1390
[46]
Kayo, T., Allison, D. B., Weindruch, R. & Prolla, T. A. Influences of aging and caloric restriction on the transcriptional profile of skeletal muscle from rhesus monkeys. Proc. Natl Acad. Sci. USA 98, 5093–5098 (2001). 10.1073/pnas.081061898
[47]
Fraser, H. B., Khaitovich, P., Plotkin, J. B., Paabo, S. & Eisen, M. B. Aging and gene expression in the primate brain. PLoS Biol. 3, e274 (2005). 10.1371/journal.pbio.0030274
[48]
Park, S. K. & Prolla, T. A. Gene expression profiling studies of aging in cardiac and skeletal muscles. Cardiovasc. Res. 66, 205–212 (2005). 10.1016/j.cardiores.2005.01.005
[49]
Bahar, R. et al. Increased cell-to-cell variation in gene expression in ageing mouse heart. Nature 441, 1011–1014 (2006). Gene-expression patterns vary between individual cells of aged cardiomyocytes. These changes appear to be stochastic and are caused by DNA damage. 10.1038/nature04844
[50]
Pletcher, S. D. et al. Genome-wide transcript profiles in aging and calorically restricted Drosophila melanogaster. Curr. Biol. 12, 712–723 (2002). 10.1016/s0960-9822(02)00808-4

Showing 50 of 86 references

Cited By
255
The Information Theory of Aging

Yuancheng Ryan Lu, Xinlong Tian · 2023

Nature Aging
Cell
SSRN Electronic Journal
The EMBO Journal
Nuclear Dynamics of Heterochromatin Repair

Nuno Amaral, Taehyun Ryu · 2017

Trends in Genetics
DNA Damage and Its Links to Neurodegeneration

Ram Madabhushi, Ling Pan · 2014

Neuron
The Hallmarks of Aging

Carlos Lopez-Otin, Maria A. Blasco · 2013

Cell
Genome Biology
Metrics
255
Citations
86
References
Details
Published
Sep 01, 2007
Vol/Issue
8(9)
Pages
692-702
License
View
Cite This Article
Philipp Oberdoerffer, David A. Sinclair (2007). The role of nuclear architecture in genomic instability and ageing. Nature Reviews Molecular Cell Biology, 8(9), 692-702. https://doi.org/10.1038/nrm2238
Related

You May Also Like

Shedding light on the cell biology of extracellular vesicles

Guillaume van Niel, Gisela D'Angelo · 2018

7,167 citations

Molecular mechanisms of epithelial–mesenchymal transition

Samy Lamouille, Jian Xu · 2014

6,770 citations

Ferroptosis: mechanisms, biology and role in disease

Xuejun Jiang, Brent R. Stockwell · 2021

6,426 citations

Membrane lipids: where they are and how they behave

Gerrit van Meer, Dennis R. Voelker · 2008

6,295 citations

Biomolecular condensates: organizers of cellular biochemistry

Salman F. Banani, Hyun O. Lee · 2017

5,869 citations