Pyramidal neurons: dendritic structure and synaptic integration

Nelson Spruston

doi:10.1038/nrn2286

journal article Mar 01, 2008

Pyramidal neurons: dendritic structure and synaptic integration

Nelson Spruston

Nature Reviews Neuroscience Vol. 9 No. 3 pp. 206-221 · Springer Science and Business Media LLC

View at Publisher Save 10.1038/nrn2286

Topics

No keywords indexed for this article. Browse by subject →

References

200

[1]

Elston, G. N. Cortex, cognition and the cell: new insights into the pyramidal neuron and prefrontal function. Cereb. Cortex 13, 1124–1138 (2003). 10.1093/cercor/bhg093

[2]

Nieuwenhuys, R. The neocortex. An overview of its evolutionary development, structural organization and synaptology. Anat. Embryol. (Berl.) 190, 307–337 (1994). 10.1007/bf00187291

[3]

Ramon y Cajal, S. Histology of the Nervous System of Man and Vertebrates (Oxford Univ. Press, Oxford, 1995). 10.1093/oso/9780195074017.001.0001

[4]

Bannister, N. J. & Larkman, A. U. Dendritic morphology of CA1 pyramidal neurones from the rat hippocampus: I. Branching patterns. J. Comp. Neurol. 360, 150–160 (1995). 10.1002/cne.903600111

[5]

Ito, M., Kato, M. & Kawabata, M. Premature bifurcation of the apical dendritic trunk of vibrissa-responding pyramidal neurones of X-irradiated rat neocortex. J. Physiol. 512, 543–553 (1998). 10.1111/j.1469-7793.1998.543be.x

[6]

DeFelipe, J. & Farinas, I. The pyramidal neuron of the cerebral cortex: morphological and chemical characteristics of the synaptic inputs. Prog. Neurobiol. 39, 563–607 (1992). 10.1016/0301-0082(92)90015-7

[7]

Gao, W. J. & Zheng, Z. H. Target-specific differences in somatodendritic morphology of layer V pyramidal neurons in rat motor cortex. J. Comp. Neurol. 476, 174–185 (2004). 10.1002/cne.20224

[8]

Kasper, E. M., Larkman, A. U., Lubke, J. & Blakemore, C. Pyramidal neurons in layer 5 of the rat visual cortex. I. Correlation among cell morphology, intrinsic electrophysiological properties, and axon targets. J. Comp. Neurol. 339, 459–474 (1994). 10.1002/cne.903390402

[9]

Turrigiano, G. G. Homeostatic plasticity in neuronal networks: the more things change, the more they stay the same. Trends Neurosci. 22, 221–227 (1999). 10.1016/s0166-2236(98)01341-1

[10]

Pinault, D. A novel single-cell staining procedure performed in vivo under electrophysiological control: morpho-functional features of juxtacellularly labeled thalamic cells and other central neurons with biocytin or Neurobiotin. J. Neurosci. Methods 65, 113–136 (1996). 10.1016/0165-0270(95)00144-1

[11]

Joshi, S. & Hawken, M. J. Loose-patch–juxtacellular recording in vivo—a method for functional characterization and labeling of neurons in macaque V1. J. Neurosci. Methods 156, 37–49 (2006). 10.1016/j.jneumeth.2006.02.004

[12]

Eccles, J. C., Llinas, R. & Sasaki, K. The excitatory synaptic action of climbing fibres on the Purkinje cells of the cerebellum. J. Physiol. 182, 268–296 (1966). 10.1113/jphysiol.1966.sp007824

[13]

Ferster, D. & Jagadeesh, B. EPSP-IPSP interactions in cat visual cortex studied with in vivo whole-cell patch recording. J. Neurosci. 12, 1262–1274 (1992). 10.1523/jneurosci.12-04-01262.1992

[14]

Pei, X., Volgushev, M., Vidyasagar, T. R. & Creutzfeldt, O. D. Whole cell recording and conductance measurements in cat visual cortex in-vivo. Neuroreport 2, 485–488 (1991). 10.1097/00001756-199108000-00019

[15]

Targeted patch-clamp recordings and single-cell electroporation of unlabeled neurons in vivo

Kazuo Kitamura, Benjamin Judkewitz, Masanobu Kano et al.

Nature Methods 2008 10.1038/nmeth1150

[16]

Brecht, M., Roth, A. & Sakmann, B. Dynamic receptive fields of reconstructed pyramidal cells in layers 3 and 2 of rat somatosensory barrel cortex. J. Physiol. 553, 243–265 (2003). 10.1113/jphysiol.2003.044222

[17]

Callaway, E. M. Cell type specificity of local cortical connections. J. Neurocytol. 31, 231–237 (2002). 10.1023/a:1024165824469

[18]

Deisseroth, K. et al. Next-generation optical technologies for illuminating genetically targeted brain circuits. J. Neurosci. 26, 10380–10386 (2006). 10.1523/jneurosci.3863-06.2006

[19]

Zhang, F. et al. Multimodal fast optical interrogation of neural circuitry. Nature 446, 633–639 (2007). 10.1038/nature05744

[20]

Miles, R. & Poncer, J. C. Paired recordings from neurones. Curr. Opin. Neurobiol. 6, 387–394 (1996). 10.1016/s0959-4388(96)80124-3

[21]

Markram, H., Lubke, J., Frotscher, M., Roth, A. & Sakmann, B. Physiology and anatomy of synaptic connections between thick tufted pyramidal neurones in the developing rat neocortex. J. Physiol. 500, 409–440 (1997). 10.1113/jphysiol.1997.sp022031

[22]

Marek, K. W. & Davis, G. W. Controlling the active properties of excitable cells. Curr. Opin. Neurobiol. 13, 607–611 (2003). 10.1016/j.conb.2003.09.001

[23]

Polleux, F. Genetic mechanisms specifying cortical connectivity: let's make some projections together. Neuron 46, 395–400 (2005). 10.1016/j.neuron.2005.04.017

[24]

Cauller, L. J. & Connors, B. W. in Single Neuron Computation (eds McKenna, T., Davis, J. & Zornetzer, S. F.) 199–230 (Academic, San Diego, 1992). 10.1016/b978-0-12-484815-3.50014-1

[25]

Cauller, L. J. & Connors, B. W. Synaptic physiology of horizontal afferents to layer I in slices of rat SI neocortex. J. Neurosci. 14, 751–762 (1994). 10.1523/jneurosci.14-02-00751.1994

[26]

Larkum, M. E., Senn, W. & Luscher, H. R. Top-down dendritic input increases the gain of layer 5 pyramidal neurons. Cereb. Cortex 14, 1059–1070 (2004). 10.1093/cercor/bhh065

[27]

Ishizuka, N., Weber, J. & Amaral, D. G. Organization of intrahippocampal projections originating from CA3 pyramidal cells in the rat. J. Comp. Neurol. 295, 580–623 (1990). 10.1002/cne.902950407

[28]

Li, X. G., Somogyi, P., Ylinen, A. & Buzsaki, G. The hippocampal CA3 network: an in vivo intracellular labeling study. J. Comp. Neurol. 339, 181–208 (1994). 10.1002/cne.903390204

[29]

Gasparini, S., Migliore, M. & Magee, J. C. On the initiation and propagation of dendritic spikes in CA1 pyramidal neurons. J. Neurosci. 24, 11046–11056 (2004). 10.1523/jneurosci.2520-04.2004

[30]

Losonczy, A. & Magee, J. C. Integrative properties of radial oblique dendrites in hippocampal CA1 pyramidal neurons. Neuron 50, 291–307 (2006). In this study, rapid uncaging of glutamate onto multiple spines on the same apical oblique dendrite of a CA1 neuron produced local dendritic spikes but did not trigger axonal action potentials. 10.1016/j.neuron.2006.03.016

[31]

Ballesteros-Yanez, I., Benavides-Piccione, R., Elston, G. N., Yuste, R. & DeFelipe, J. Density and morphology of dendritic spines in mouse neocortex. Neuroscience 138, 403–409 (2006). 10.1016/j.neuroscience.2005.11.038

[32]

Elston, G. N. & DeFelipe, J. Spine distribution in cortical pyramidal cells: a common organizational principle across species. Prog. Brain Res. 136, 109–133 (2002). 10.1016/s0079-6123(02)36012-6

[33]

Sorra, K. E. & Harris, K. M. Overview on the structure, composition, function, development, and plasticity of hippocampal dendritic spines. Hippocampus 10, 501–511 (2000). 10.1002/1098-1063(2000)10:5<501::aid-hipo1>3.0.co;2-t

[34]

Bonhoeffer, T. & Yuste, R. Spine motility. Phenomenology, mechanisms, and function. Neuron 35, 1019–1027 (2002). 10.1016/s0896-6273(02)00906-6

[35]

Grutzendler, J., Kasthuri, N. & Gan, W. B. Long-term dendritic spine stability in the adult cortex. Nature 420, 812–816 (2002). 10.1038/nature01276

[36]

Trachtenberg, J. T. et al. Long-term in vivo imaging of experience-dependent synaptic plasticity in adult cortex. Nature 420, 788–794 (2002). 10.1038/nature01273

[37]

Holtmaat, A. J. et al. Transient and persistent dendritic spines in the neocortex in vivo. Neuron 45, 279–291 (2005). 10.1016/j.neuron.2005.01.003

[38]

Holtmaat, A., Wilbrecht, L., Knott, G. W., Welker, E. & Svoboda, K. Experience-dependent and cell-type-specific spine growth in the neocortex. Nature 441, 979–983 (2006). 10.1038/nature04783

[39]

Kasai, H., Matsuzaki, M., Noguchi, J., Yasumatsu, N. & Nakahara, H. Structure–stability–function relationships of dendritic spines. Trends Neurosci. 26, 360–368 (2003). 10.1016/s0166-2236(03)00162-0

[40]

Bourne, J. & Harris, K. M. Do thin spines learn to be mushroom spines that remember? Curr. Opin. Neurobiol. 17, 381–386 (2007). 10.1016/j.conb.2007.04.009

[41]

Matsuzaki, M., Honkura, N., Ellis-Davies, G. C. & Kasai, H. Structural basis of long-term potentiation in single dendritic spines. Nature 429, 761–766 (2004). 10.1038/nature02617

[42]

Matus, A. Actin-based plasticity in dendritic spines. Science 290, 754–758 (2000). 10.1126/science.290.5492.754

[43]

Yankova, M., Hart, S. A. & Woolley, C. S. Estrogen increases synaptic connectivity between single presynaptic inputs and multiple postsynaptic CA1 pyramidal cells: a serial electron-microscopic study. Proc. Natl Acad. Sci. USA 98, 3525–3530 (2001). 10.1073/pnas.051624598

[44]

Occurrence and three-dimensional structure of multiple synapses between individual radiatum axons and their target pyramidal cells in hippocampal area CA1

KE Sorra, KM Harris

The Journal of Neuroscience 1993 10.1523/jneurosci.13-09-03736.1993

[45]

Woolley, C. S., Wenzel, H. J. & Schwartzkroin, P. A. Estradiol increases the frequency of multiple synapse boutons in the hippocampal CA1 region of the adult female rat. J. Comp. Neurol. 373, 108–117 (1996). 10.1002/(sici)1096-9861(19960909)373:1<108::aid-cne9>3.0.co;2-8

[46]

Cohen, R. S., Blomberg, F., Berzins, K. & Siekevitz, P. The structure of postsynaptic densities isolated from dog cerebral cortex. I. Overall morphology and protein composition. J. Cell Biol. 74, 181–203 (1977). 10.1083/jcb.74.1.181

[47]

Cohen, R. S. & Siekevitz, P. Form of the postsynaptic density. A serial section study. J. Cell Biol. 78, 36–46 (1978). 10.1083/jcb.78.1.36

[48]

Peters, A. & Kaiserman-Abramof, I. R. The small pyramidal neuron of the rat cerebral cortex. The synapses upon dendritic spines. Z. Zellforsch. Mikrosk. Anat. 100, 487–506 (1969). 10.1007/bf00344370

[49]

Harris, K. M. & Stevens, J. K. Dendritic spines of CA 1 pyramidal cells in the rat hippocampus: serial electron microscopy with reference to their biophysical characteristics. J. Neurosci. 9, 2982–2997 (1989). 10.1523/jneurosci.09-08-02982.1989

[50]

Geinisman, Y., Detoledo-Morrell, L., Morrell, F., Persina, I. S. & Beatty, M. A. Synapse restructuring associated with the maintenance phase of hippocampal long-term potentiation. J. Comp. Neurol. 368, 413–423 (1996). 10.1002/(sici)1096-9861(19960506)368:3<413::aid-cne7>3.0.co;2-8

Showing 50 of 200 references

Cited By

1,472

Scalable spatial single-cell transcriptomics and translatomics in 3D thick tissue blocks

Xin Sui, Jennifer A. Lo · 2025

Nature Methods

Synaptic cell-adhesion molecule latrophilin-2 is differentially directed to dendritic domains of hippocampal neurons

Thomas R. Murphy, Ryan F. Amidon · 2024

iScience

Identifying transcranial magnetic stimulation induced EEG signatures of different neuronal elements in primary motor cortex

Zhen Ni, Sinisa Pajevic · 2022

Clinical Neurophysiology

Dendritic involvement in inhibition and disinhibition of vulnerable dopaminergic neurons in healthy and pathological conditions

R.C. Evans · 2022

Neurobiology of Disease

Serotonergic psychedelics LSD & psilocybin increase the fractal dimension of cortical brain activity in spatial and temporal domains

Thomas F. Varley, Robin Carhart-Harris · 2020

NeuroImage

Interneuron Types as Attractors and Controllers

Gord Fishell, Adam Kepecs · 2020

Annual Review of Neuroscience

Neonatal Ethanol and Choline Treatments Alter the Morphology of Developing Rat Hippocampal Pyramidal Neurons in Opposite Directions

C.M. Goeke, M.L. Roberts · 2018

Neuroscience

Postsynaptic adhesion GPCR latrophilin-2 mediates target recognition in entorhinal-hippocampal synapse assembly

Garret R. Anderson, Stephan Maxeiner · 2017

The Journal of cell biology

Degeneracy in the regulation of short‐term plasticity and synaptic filtering by presynaptic mechanisms

Chinmayee L. Mukunda, Rishikesh Narayanan · 2017

The Journal of Physiology

Active Properties of Neocortical Pyramidal Neuron Dendrites

Guy Major, Matthew E. Larkum · 2013

Annual Review of Neuroscience

Phenotypic characterization of C57BL/6J mice carrying the Disc1 gene from the 129S6/SvEv strain

Liang-Wen Juan, Chun-Chieh Liao · 2013

Brain Structure and Function

An Autism-Associated Variant of Epac2 Reveals a Role for Ras/Epac2 Signaling in Controlling Basal Dendrite Maintenance in Mice

Deepak P. Srivastava, Kevin M. Woolfrey · 2012

PLOS Biology

Branching out: mechanisms of dendritic arborization

Yuh-Nung Jan, Lily Yeh Jan · 2010

Nature Reviews Neuroscience

GABAergic interneurons targeting dendrites of pyramidal cells in the CA1 area of the hippocampus

Thomas Klausberger · 2009

European Journal of Neuroscience

Proximity of excitatory and inhibitory axon terminals adjacent to pyramidal cell bodies provides a putative basis for nonsynaptic interactions

Angel Merchán-Pérez, José-Rodrigo Rodríguez · 2009

Proceedings of the National Academy...

Metrics

1,472

Citations

200

References

Details

Published: Mar 01, 2008
Vol/Issue: 9(3)
Pages: 206-221
License: View

Authors

N

Nelson Spruston

Cite This Article

Nelson Spruston (2008). Pyramidal neurons: dendritic structure and synaptic integration. Nature Reviews Neuroscience, 9(3), 206-221. https://doi.org/10.1038/nrn2286

Pyramidal neurons: dendritic structure and synaptic integration

You May Also Like