Topics

No keywords indexed for this article. Browse by subject →

References
43
[1]
Hille, B. Ion Channels of Excitable Membranes (Sinauer, Sunderland, Massachusetts, USA, 2001).
[2]
Armstrong, C.M. Interaction of tetraethylammonium ion derivatives with the potassium channels of giant axons. J. Gen. Physiol. 58, 413–437 (1971). 10.1085/jgp.58.4.413
[3]
Choi, K.L., Mossman, C., Aube, J. & Yellen, G. The internal quaternary ammonium receptor site of Shaker potassium channels. Neuron 10, 533–541 (1993). 10.1016/0896-6273(93)90340-w
[4]
Mutations Affecting Tea Blockade and Ion Permeation in Voltage-activated K + Channels

Roderick MacKinnon, Gary Yellen

Science 1990 10.1126/science.2218530
[5]
Kavanaugh, M.P. et al. Interaction between tetraethylammonium and amino acid residues in the pore of cloned voltage-dependent potassium channels. J. Biol. Chem. 266, 7583–7587 (1991). 10.1016/s0021-9258(20)89487-3
[6]
Single Streptomyces lividans K+ Channels

Lise Heginbotham, Meredith LeMasurier, Ludmilla Kolmakova-Partensky et al.

Journal of General Physiology 1999 10.1085/jgp.114.4.551
[7]
Heginbotham, L. & MacKinnon, R. The aromatic binding site for tetraethylammonium ion on potassium channels. Neuron 8, 483–491 (1992). 10.1016/0896-6273(92)90276-j
[8]
Extracellular Blockade of K+ Channels by Tea

Serge Crouzy, Simon Bernèche, Benoît Roux

Journal of General Physiology 2001 10.1085/jgp.118.2.207
[9]
Luzhkov, V.B. & Aqvist, J. Mechanisms of tetraethylammonium ion block in the KcsA potassium channel. FEBS Lett. 495, 191–196 (2001). 10.1016/s0014-5793(01)02381-x
[10]
Guidoni, L. & Carloni, P. Tetraethylammonium binding to the outer mouth of the KcsA potassium channel: implications for ion permeation. J. Recept. Signal Transduct. Res. 22, 315–331 (2002). 10.1081/rrs-120014604
[11]
Woodhull, A.M. Ionic blockage of sodium channels in nerve. J. Gen. Physiol. 61, 687–708 (1973). 10.1085/jgp.61.6.687
[12]
Spassova, M. & Lu, Z. Coupled ion movement underlies rectification in an inward-rectifier K+ channel. J. Gen. Physiol. 112, 211–221 (1998). 10.1085/jgp.112.2.211
[13]
Thompson, J. & Begenisich, T. External TEA block of Shaker K+ channels is coupled to the movement of K+ ions within the selectivity filter. J. Gen. Physiol. 122, 239–246 (2003). 10.1085/jgp.200308848
[14]
Kutluay, E., Roux, B. & Heginbotham, L. Rapid intracellular TEA block of the KcsA potassium channel. Biophys. J. 88, 1018–1029 (2005). 10.1529/biophysj.104.052043
[15]
Zhou, M., Morais-Cabral, J.H., Mann, S. & MacKinnon, R. Potassium channel receptor site for the inactivation gate and quaternary amine inhibitors. Nature 411, 657–661 (2001). 10.1038/35079500
[16]
Newland, C.F., Adelman, J.P., Tempel, B.L. & Almers, W. Repulsion between tetraethyl-ammonium ions in cloned voltage-gated potassium channels. Neuron 8, 975–982 (1992). 10.1016/0896-6273(92)90212-v
[17]
Thompson, J. & Begenisich, T. Interaction between quaternary ammonium ions in the pore of potassium channels. Evidence against an electrostatic repulsion mechanism. J. Gen. Physiol. 115, 769–782 (2000). 10.1085/jgp.115.6.769
[18]
Grissmer, S. & Cahalan, M. TEA prevents inactivation while blocking open K+ channels in human T lymphocytes. Biophys. J. 55, 203–206 (1989). 10.1016/s0006-3495(89)82793-6
[19]
Choi, K.L., Aldrich, R.W. & Yellen, G. Tetraethylammonium blockade distinguishes two inactivation mechanisms in voltage-activated K+ channels. Proc. Natl. Acad. Sci. USA 88, 5092–5095 (1991). 10.1073/pnas.88.12.5092
[20]
Hoshi, T., Zagotta, W.N. & Aldrich, R.W. Two types of inactivation in Shaker K+ channels: effects of alterations in the carboxy-terminal region. Neuron 7, 547–556 (1991). 10.1016/0896-6273(91)90367-9
[21]
Yellen, G., Sodickson, D., Chen, T.Y. & Jurman, M.E. An engineered cysteine in the external mouth of a K+ channel allows inactivation to be modulated by metal binding. Biophys. J. 66, 1068–1075 (1994). 10.1016/s0006-3495(94)80888-4
[22]
Liu, Y., Jurman, M.E. & Yellen, G. Dynamic rearrangement of the outer mouth of a K+ channel during gating. Neuron 16, 859–867 (1996). 10.1016/s0896-6273(00)80106-3
[23]
Ogielska, E.M. & Aldrich, R.W. Functional consequences of a decreased potassium affinity in a potassium channel pore. Ion interactions and C-type inactivation. J. Gen. Physiol. 113, 347–358 (1999). 10.1085/jgp.113.2.347
[24]
Lopez-Barneo, J., Hoshi, T., Heinemann, S.H. & Aldrich, R.W. Effects of external cations and mutations in the pore region on C-type inactivation of Shaker potassium channels. Receptors Channels 1, 61–71 (1993).
[25]
Ogielska, E.M. et al. Cooperative subunit interactions in C-type inactivation of K channels. Biophys. J. 69, 2449–2457 (1995). 10.1016/s0006-3495(95)80114-1
[26]
Baukrowitz, T. & Yellen, G. Modulation of K+ current by frequency and external [K+]: a tale of two inactivation mechanisms. Neuron 15, 951–960 (1995). 10.1016/0896-6273(95)90185-x
[27]
Baukrowitz, T. & Yellen, G. Use-dependent blockers and exit rate of the last ion from the multi-ion pore of a K+ channel. Science 271, 653–656 (1996). 10.1126/science.271.5249.653
[28]
Chemistry of ion coordination and hydration revealed by a K+ channel–Fab complex at 2.0 Å resolution

Yufeng Zhou, João H. Morais-Cabral, Amelia Kaufman et al.

Nature 2001 10.1038/35102009
[29]
Energetic optimization of ion conduction rate by the K+ selectivity filter

João H. Morais-Cabral, Yufeng Zhou, Roderick MacKinnon

Nature 2001 10.1038/35102000
[30]
Zhou, Y. & MacKinnon, R. The occupancy of ions in the K+ selectivity filter: charge balance and coupling of ion binding to a protein conformational change underlie high conduction rates. J. Mol. Biol. 333, 965–975 (2003). 10.1016/j.jmb.2003.09.022
[31]
Roux, B. & MacKinnon, R. The cavity and pore helices in the KcsA K+ channel: electro-static stabilization of monovalent cations. Science 285, 100–102 (1999). 10.1126/science.285.5424.100
[32]
Zhou, Y. & MacKinnon, R. Ion binding affinity in the cavity of the KcsA potassium channel. Biochemistry 43, 4978–4982 (2004). 10.1021/bi049876z
[33]
Energetics of ion conduction through the K+ channel

Simon Bernèche, Benoît Roux

Nature 2001 10.1038/35102067
[34]
Thoden, J.B. et al. Carbamoyl phosphate synthetase: caught in the act of glutamine hydrolysis. Biochemistry 37, 8825–8831 (1998). 10.1021/bi9807761
[35]
Ikeda, S.R. & Korn, S.J. Influence of permeating ions on potassium channel block by external tetraethylammonium. J. Physiol. 486, 267–272 (1995). 10.1113/jphysiol.1995.sp020809
[36]
Ion conduction pore is conserved among potassium channels

Zhe Lu, Angela M. Klem, Yajamana Ramu

Nature 2001 10.1038/35101535
[37]
The Structure of the Potassium Channel: Molecular Basis of K + Conduction and Selectivity

Declan A. Doyle, João Morais Cabral, Richard A. Pfuetzner et al.

Science 1998 10.1126/science.280.5360.69
[38]
Friedrich, M.E.P. & Marvel, C.S. Reaction between alkali metal alkyls and quaternary arsonium compounds. J. Am. Chem. Soc. 52, 376–384 (1930). 10.1021/ja01364a056
[39]
Automatic processing of rotation diffraction data from crystals of initially unknown symmetry and cell constants

W. Kabsch

Journal of Applied Crystallography 1993 10.1107/s0021889893005588
[40]
Crystallography & NMR System: A New Software Suite for Macromolecular Structure Determination

A. T. Brünger, P. D. Adams, G. M. Clore et al.

Acta Crystallographica Section D Biological Crysta... 1998 10.1107/s0907444998003254
[41]
Refinement of Macromolecular Structures by the Maximum-Likelihood Method

G. N. Murshudov, A. A. Vagin, E. J. Dodson

Acta Crystallographica Section D Biological Crysta... 1997 10.1107/s0907444996012255
[42]
MOLSCRIPT: a program to produce both detailed and schematic plots of protein structures

P. J. Kraulis

Journal of Applied Crystallography 1991 10.1107/s0021889891004399
[43]
[26] Raster3D: Photorealistic molecular graphics

Ethan A. Merritt, David J. Bacon

Methods in Enzymology 1997 10.1016/s0076-6879(97)77028-9
Metrics
139
Citations
43
References
Details
Published
Apr 24, 2005
Vol/Issue
12(5)
Pages
454-459
License
View
Cite This Article
Michael J Lenaeus, Magdalini Vamvouka, Pamela J Focia, et al. (2005). Structural basis of TEA blockade in a model potassium channel. Nature Structural & Molecular Biology, 12(5), 454-459. https://doi.org/10.1038/nsmb929
Related

You May Also Like

Announcing the worldwide Protein Data Bank

Helen Berman, Kim Henrick · 2003

2,657 citations

From Levinthal to pathways to funnels

Ken A. Dill, Hue Sun Chan · 1997

1,964 citations

Experimentally determined hydrophobicity scale for proteins at membrane interfaces

William C. Wimley, Stephen H. White · 1996

1,473 citations

EGCG redirects amyloidogenic polypeptides into unstructured, off-pathway oligomers

Dagmar E Ehrnhoefer, Jan Bieschke · 2008

1,310 citations