Oncogenic K-Ras requires activation for enhanced activity

H Huang; J Daniluk; J Chu; Z Li; B Ji; C D Logsdon

doi:10.1038/onc.2012.619

journal article Jan 21, 2013

Oncogenic K-Ras requires activation for enhanced activity

H Huang

J Daniluk J Chu Z Li B Ji C D Logsdon

Oncogene Vol. 33 No. 4 pp. 532-535 · Springer Science and Business Media LLC

View at Publisher Save 10.1038/onc.2012.619

Topics

No keywords indexed for this article. Browse by subject →

References

21

[1]

Spaargaren M, Bischoff JR, McCormick F . Signal transduction by Ras-like GTPases: a potential target for anticancer drugs. Gene Expr 1995; 4: 345–356.

[2]

Scheffzek K, Ahmadian MR, Kabsch W, Wiesmuller L, Lautwein A, Schmitz F et al. The Ras-RasGAP complex: structural basis for GTPase activation and its loss in oncogenic Ras mutants. Science 1997; 277: 333–338. 10.1126/science.277.5324.333

[3]

Koeffler HP, McCormick F, Denny C . Molecular mechanisms of cancer. West J Med 1991; 155: 505–514.

[4]

RAS oncogenes: weaving a tumorigenic web

Yuliya Pylayeva-Gupta, Elda Grabocka, Dafna Bar-Sagi

Nature Reviews Cancer 2011 10.1038/nrc3106

[5]

Karnoub AE, Weinberg RA . Ras oncogenes: split personalities. Nat Rev Mol Cell Biol 2008; 9: 517–531. 10.1038/nrm2438

[6]

Yan L, McFaul C, Howes N, Leslie J, Lancaster G, Wong T et al. Molecular analysis to detect pancreatic ductal adenocarcinoma in high-risk groups. Gastroenterology 2005; 128: 2124–2130. 10.1053/j.gastro.2005.03.006

[7]

Lu X, Xu T, Qian J, Wen X, Wu D . Detecting K-ras and p53 gene mutation from stool and pancreatic juice for diagnosis of early pancreatic cancer. Chin Med J 2002; 115: 1632–1636.

[8]

Parsons BL, Meng F . K-RAS mutation in the screening, prognosis and treatment of cancer. Biomark Med 2009; 3: 757–769. 10.2217/bmm.09.95

[9]

Yakubovskaya MS, Spiegelman V, Luo FC, Malaev S, Salnev A, Zborovskaya I et al. High frequency of K-ras mutations in normal appearing lung tissues and sputum of patients with lung cancer. Int J Cancer 1995; 63: 810–814. 10.1002/ijc.2910630611

[10]

Guerra C, Mijimolle N, Dhawahir A, Dubus P, Barradas M, Serrano M et al. Tumor induction by an endogenous K-ras oncogene is highly dependent on cellular context. Cancer cell 2003; 4: 111–120. 10.1016/s1535-6108(03)00191-0

[11]

Carriere C, Young AL, Gunn JR, Longnecker DS, Korc M . Acute pancreatitis markedly accelerates pancreatic cancer progression in mice expressing oncogenic Kras. Biochem Biophys Res Commun 2009; 382: 561–565. 10.1016/j.bbrc.2009.03.068

[12]

Daniluk J, Liu Y, Deng D, Chu J, Huang H, Gaiser S et al. An NF-kappaB pathway-mediated positive feedback loop amplifies Ras activity to pathological levels in mice. J Clin Invest 2012; 122: 1519–1528. 10.1172/jci59743

[13]

Tada M, Ohashi M, Shiratori Y, Okudaira T, Komatsu Y, Kawabe T et al. Analysis of K-ras gene mutation in hyperplastic duct cells of the pancreas without pancreatic disease. Gastroenterology (Research Support, Non-U.S. Gov't) 1996; 110: 227–231. 10.1053/gast.1996.v110.pm8536861

[14]

Preinvasive and invasive ductal pancreatic cancer and its early detection in the mouse

Sunil R. Hingorani, Emanuel F. Petricoin, Anirban Maitra et al.

Cancer Cell 2003 10.1016/s1535-6108(03)00309-x

[15]

Ji B, Song J, Tsou L, Bi Y, Gaiser S, Mortensen R et al. Robust acinar cell transgene expression of CreErT via BAC recombineering. Genesis 2008; 46: 390–395. 10.1002/dvg.20411

[16]

Ardito CM, Gruner BM, Takeuchi KK, Lubeseder-Martellato C, Teichmann N, Mazur PK et al. EGF Receptor Is Required for KRAS-Induced Pancreatic Tumorigenesis. Cancer cell 2012; 22: 304–317. 10.1016/j.ccr.2012.07.024

[17]

Siveke JT, Einwachter H, Sipos B, Lubeseder-Martellato C, Kloppel G, Schmid RM . Concomitant pancreatic activation of Kras(G12D) and Tgfa results in cystic papillary neoplasms reminiscent of human IPMN. Cancer cell 2007; 12: 266–279. 10.1016/j.ccr.2007.08.002

[18]

Guerra C, Schuhmacher AJ, Canamero M, Grippo PJ, Verdaguer L, Perez-Gallego L et al. Chronic pancreatitis is essential for induction of pancreatic ductal adenocarcinoma by K-Ras oncogenes in adult mice. Cancer cell 2007; 11: 291–302. 10.1016/j.ccr.2007.01.012

[19]

Analysis of lung tumor initiation and progression using conditional expression of oncogenic K-ras

Erica L. Jackson, Nicholas Willis, Kim Mercer et al.

Genes & Development 2001 10.1101/gad.943001

[20]

Williams JA, Korc M, Dormer RL . Action of secretagogues on a new preparation of functionally intact, isolated pancreatic acini. Am J Physiol 1978; 235: 517–524.

[21]

de Rooij J, Bos JL . Minimal Ras-binding domain of Raf1 can be used as an activation-specific probe for Ras. Oncogene 1997; 14: 623–625. 10.1038/sj.onc.1201005

Cited By

119

Obesity and Pancreatic Cancer: Insight into Mechanisms

Guido Eibl, Enrique Rozengurt · 2021

Cancers

Metrics

119

Citations

21

References

Details

Published: Jan 21, 2013
Vol/Issue: 33(4)
Pages: 532-535
License: View

Authors

School of Clinical and Experimental Medicine University of Birmingham Birmingham Women's Hospital Foundation Trust Birmingham UK

Z

Z Li

Baker Laboratory of Chemistry, Cornell University, Ithaca, NY 14853-1301.

Cite This Article

H Huang, J Daniluk, J Chu, et al. (2013). Oncogenic K-Ras requires activation for enhanced activity. Oncogene, 33(4), 532-535. https://doi.org/10.1038/onc.2012.619

Oncogenic K-Ras requires activation for enhanced activity

You May Also Like