ROS in cancer therapy: the bright side of the moon

Bruno Perillo; Marzia Di Donato; Antonio Pezone; Erika Di Zazzo; Pia Giovannelli; Giovanni Galasso; Gabriella Castoria; Antimo Migliaccio

doi:10.1038/s12276-020-0384-2

journal article Open Access Feb 01, 2020

ROS in cancer therapy: the bright side of the moon

Bruno Perillo Marzia Di Donato

Antonio Pezone Erika Di Zazzo

Pia Giovannelli

Giovanni Galasso Gabriella Castoria

Antimo Migliaccio

Experimental & Molecular Medicine Vol. 52 No. 2 pp. 192-203 · Springer Science and Business Media LLC

View at Publisher Save 10.1038/s12276-020-0384-2

Abstract

AbstractReactive oxygen species (ROS) constitute a group of highly reactive molecules that have evolved as regulators of important signaling pathways. It is now well accepted that moderate levels of ROS are required for several cellular functions, including gene expression. The production of ROS is elevated in tumor cells as a consequence of increased metabolic rate, gene mutation and relative hypoxia, and excess ROS are quenched by increased antioxidant enzymatic and nonenzymatic pathways in the same cells. Moderate increases of ROS contribute to several pathologic conditions, among which are tumor promotion and progression, as they are involved in different signaling pathways and induce DNA mutation. However, ROS are also able to trigger programmed cell death (PCD). Our review will emphasize the molecular mechanisms useful for the development of therapeutic strategies that are based on modulating ROS levels to treat cancer. Specifically, we will report on the growing data that highlight the role of ROS generated by different metabolic pathways as Trojan horses to eliminate cancer cells.

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Published: Feb 01, 2020
Vol/Issue: 52(2)
Pages: 192-203
License: View

Authors

Department of Medicine and Health Sciences “V. Tiberio”, University of Molise, 86100 Campobasso, Italy

Dipartimento di Patologia Generale, Facoltà di Medicina e Chirurgia, II Università di Napoli, Naples, Italy

A

Antimo Migliaccio

Dipartimento di Patologia Generale, Facoltà di Medicina e Chirurgia, II Università di Napoli, Naples, Italy

Cite This Article

Bruno Perillo, Marzia Di Donato, Antonio Pezone, et al. (2020). ROS in cancer therapy: the bright side of the moon. Experimental & Molecular Medicine, 52(2), 192-203. https://doi.org/10.1038/s12276-020-0384-2

ROS in cancer therapy: the bright side of the moon

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