Genetics of structural and functional brain changes in autism spectrum disorder

Sheema Hashem; Sabah Nisar; Ajaz A. Bhat; Santosh Kumar Yadav; Muhammad Waqar Azeem; Puneet Bagga; Khalid Fakhro; Ravinder Reddy; Michael P. Frenneaux; Mohammad Haris

doi:10.1038/s41398-020-00921-3

journal article Open Access Jul 13, 2020

Genetics of structural and functional brain changes in autism spectrum disorder

Sheema Hashem Sabah Nisar Ajaz A. Bhat

Santosh Kumar Yadav

Muhammad Waqar Azeem Puneet Bagga

Khalid Fakhro Ravinder Reddy

Michael P. Frenneaux Mohammad Haris

Translational Psychiatry Vol. 10 No. 1 · Springer Science and Business Media LLC

View at Publisher Save 10.1038/s41398-020-00921-3

Abstract

AbstractAutism spectrum disorder (ASD) is a neurological and developmental disorder characterized by social impairment and restricted interactive and communicative behaviors. It may occur as an isolated disorder or in the context of other neurological, psychiatric, developmental, and genetic disorders. Due to rapid developments in genomics and imaging technologies, imaging genetics studies of ASD have evolved in the last few years. Increased risk for ASD diagnosis is found to be related to many specific single-nucleotide polymorphisms, and the study of genetic mechanisms and noninvasive imaging has opened various approaches that can help diagnose ASD at the nascent level. Identifying risk genes related to structural and functional changes in the brain of ASD patients provide a better understanding of the disease’s neuropsychiatry and can help identify targets for therapeutic intervention that could be useful for the clinical management of ASD patients.

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Published: Jul 13, 2020
Vol/Issue: 10(1)
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Authors

Epigenetics Cardiovascular Laboratory, Department of Genetic Medicine, Weill Cornell Medicine-Qatar, PO box 24144, Doha, Qatar; Department of Human Genetics, Sidra Medical & Research Centre, PO box 26999, Doha, Qatar

Cite This Article

Sheema Hashem, Sabah Nisar, Ajaz A. Bhat, et al. (2020). Genetics of structural and functional brain changes in autism spectrum disorder. Translational Psychiatry, 10(1). https://doi.org/10.1038/s41398-020-00921-3

Genetics of structural and functional brain changes in autism spectrum disorder

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