Hydrogel tapes for fault-tolerant strong wet adhesion

Bin Xue; Jie Gu; Lan Li; WenTing Yu; Sheng Yin; Meng Qin; Qing Jiang; Wei Wang; Yi Cao

doi:10.1038/s41467-021-27529-5

journal article Open Access Dec 09, 2021

Hydrogel tapes for fault-tolerant strong wet adhesion

Bin Xue

WenTing Yu Sheng Yin

Nature Communications Vol. 12 No. 1 · Springer Science and Business Media LLC

View at Publisher Save 10.1038/s41467-021-27529-5

Abstract

Abstract
Fast and strong bio-adhesives are in high demand for many biomedical applications, including closing wounds in surgeries, fixing implantable devices, and haemostasis. However, most strong bio-adhesives rely on the instant formation of irreversible covalent crosslinks to provide strong surface binding. Repositioning misplaced adhesives during surgical operations may cause severe secondary damage to tissues. Here, we report hydrogel tapes that can form strong physical interactions with tissues in seconds and gradually form covalent bonds in hours. This timescale-dependent adhesion mechanism allows instant and robust wet adhesion to be combined with fault-tolerant convenient surgical operations. Specifically, inspired by the catechol chemistry discovered in mussel foot proteins, we develop an electrical oxidation approach to controllably oxidize catechol to catecholquinone, which reacts slowly with amino groups on the tissue surface. We demonstrate that the tapes show fast and reversible adhesion at the initial stage and ultrastrong adhesion after the formation of covalent linkages over hours for various tissues and electronic devices. Given that the hydrogel tapes are biocompatible, easy to use, and robust for bio-adhesion, we anticipate that they may find broad biomedical and clinical applications.

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Details

Published: Dec 09, 2021
Vol/Issue: 12(1)
License: View

Authors

Wenzhou University

Hong Kong University of Science and Technology

Y

Yi Cao

School of Psychological and Cognitive Sciences, Peking University, Beijing 100871, China

Funding

National Natural Science Foundation of China Award: 11804148

Natural Science Foundation of Jiangsu Province Award: BK20180320

Cite This Article

Bin Xue, Jie Gu, Lan Li, et al. (2021). Hydrogel tapes for fault-tolerant strong wet adhesion. Nature Communications, 12(1). https://doi.org/10.1038/s41467-021-27529-5

Hydrogel tapes for fault-tolerant strong wet adhesion

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