Biomolecular sensors for advanced physiological monitoring

Karamanou, M., Protogerou, A., Tsoucalas, G., Androutsos, G. & Poulakou-Rebelakou, E. Milestones in the history of diabetes mellitus: the main contributors. World J. Diabetes 7, 1–7 (2016). 10.4239/wjd.v7.i1.1

[4]

Thomas, M. C., Jandeleit-Dahm, K. & Bonnet, F. Beyond glycosuria: exploring the intrarenal effects of SGLT-2 inhibition in diabetes. Diabetes Metab. 40, S17–S22 (2014). 10.1016/s1262-3636(14)72691-6

[5]

Guthrie, D. W. & Humphreys, S. S. Diabetes urine testing: an historical perspective. Diabetes Educ. 14, 521–525 (1988). 10.1177/014572178801400615

[6]

Clark, L. C. Jr & Lyons, C. Electrode systems for continuous monitoring in cardiovascular surgery. Ann. NY Acad. Sci. 102, 29–45 (1962). This article describes the first electrochemical sensing platform that incorporates a biorecognition element to provide selectivity for an analyte. 10.1111/j.1749-6632.1962.tb13623.x

[7]

Clark, L. C., Kaplan, S., Matthews, E. C., Edwards, F. K. & Helmsworth, J. A. Monitor and control of blood oxygen tension and pH during total body perfusion. J. Thorac. Surg. 36, 488–496 (1958). 10.1016/s0096-5588(20)30126-4

[8]

Free, A. H., Adams, E. C., Kercher, M. L., Free, H. M. & Cook, M. H. Simple specific test for urine glucose. Clin. Chem. 3, 163–168 (1957). This article describes the first time a biorecognition element was incorporated into a sensing mechanism, despite this feat being usually misattributed to Clark and Lyons (1962). 10.1093/clinchem/3.3.163

[9]

Mazzaferri, E. L., Skillman, T. G., Lanese, R. R. & Keller, M. P. Use of test strips with colour meter to measure blood-glucose. Lancet 295, 331–333 (1970). 10.1016/s0140-6736(70)90706-3

[10]

Chua, K. S. & Tan, I. K. Plasma glucose measurement with the Yellow Springs glucose analyzer. Clin. Chem. 24, 150–152 (1978). 10.1093/clinchem/24.1.150

[11]

Clarke, S. F. & Foster, J. R. A history of blood glucose meters and their role in self-monitoring of diabetes mellitus. Br. J. Biomed. Sci. 69, 83–93 (2012). 10.1080/09674845.2012.12002443

[12]

Matthews, D. R. et al. Pen-sized digital 30-second blood glucose meter. Lancet 329, 778–779 (1987). 10.1016/s0140-6736(87)92802-9

[13]

Ginsberg, B. H. The FDA panel advises approval of the first continuous glucose sensor. Diabetes Technol. Ther. 1, 203–204 (1999). 10.1089/152091599317431

[14]

Kelley, S. O. et al. Advancing the speed, sensitivity and accuracy of biomolecular detection using multi-length-scale engineering. Nat. Nanotechnol. 9, 969–980 (2014). 10.1038/nnano.2014.261

[15]

Sero, J. E. & Stevens, M. M. Nanoneedle-based materials for intracellular studies. In Bio-Nanomedicine For Cancer Therapy 191–219 (Springer, 2021). 10.1007/978-3-030-58174-9_9

[16]

Chiappini, C. et al. Mapping local cytosolic enzymatic activity in human esophageal mucosa with porous silicon nanoneedles. Adv. Mater. 27, 5147–5152 (2015). 10.1002/adma.201501304

[17]

Cao, Y. et al. Nondestructive nanostraw intracellular sampling for longitudinal cell monitoring. Proc. Natl Acad. Sci. USA 114, E1866–E1874 (2017). 10.1073/pnas.1615375114

[18]

Siciliano, V. et al. Engineering modular intracellular protein sensor–actuator devices. Nat. Commun. 9, 1881 (2018). 10.1038/s41467-018-03984-5

[19]

Poste, G. Bring on the biomarkers. Nature 469, 156–157 (2011). 10.1038/469156a

[20]

Yang, Y. et al. A laser-engraved wearable sensor for sensitive detection of uric acid and tyrosine in sweat. Nat. Biotechnol. 38, 217–224 (2020). 10.1038/s41587-019-0321-x

[21]

Weinhofer, I. et al. Neurofilament light chain as a potential biomarker for monitoring neurodegeneration in X-linked adrenoleukodystrophy. Nat. Commun. 12, 1816 (2021). 10.1038/s41467-021-22114-2

[22]

Kwong, G. A. et al. Synthetic biomarkers: a twenty-first century path to early cancer detection. Nat. Rev. Cancer 21, 655–668 (2021). This review describes the development of synthetic biomarkers, including their function at the physiological level, their design and how they advance biomolecular sensing. 10.1038/s41568-021-00389-3

[23]

Nishihara, T. et al. Beta-galactosidase-responsive synthetic biomarker for targeted tumor detection. Chem. Commun. 54, 11745–11748 (2018). 10.1039/c8cc06068a

[24]

Chan, L. W. et al. Engineering synthetic breath biomarkers for respiratory disease. Nat. Nanotechnol. 15, 792–800 (2020). 10.1038/s41565-020-0723-4

[25]

Aalipour, A. et al. Engineered immune cells as highly sensitive cancer diagnostics. Nat. Biotechnol. 37, 531–539 (2019). 10.1038/s41587-019-0064-8

[26]

Chen, J. et al. Glucose-oxidase like catalytic mechanism of noble metal nanozymes. Nat. Commun. 12, 3375 (2021). 10.1038/s41467-021-23737-1

[27]

Liu, S. et al. Metal–organic frameworks and their derivatives as signal amplification elements for electrochemical sensing. Coord. Chem. Rev. 424, 213520 (2020). 10.1016/j.ccr.2020.213520

[28]

Huang, Y., Ren, J. & Qu, X. Nanozymes: classification, catalytic mechanisms, activity regulation, and applications. Chem. Rev. 119, 4357–4412 (2019). 10.1021/acs.chemrev.8b00672

[29]

Hu, W.-C. et al. Ultrasensitive detection of bacteria using a 2D MOF nanozyme-amplified electrochemical detector. Anal. Chem. 93, 8544–8552 (2021). 10.1021/acs.analchem.1c01261

[30]

Huang, L., Chen, J., Gan, L., Wang, J. & Dong, S. Single-atom nanozymes. Sci. Adv. 5, eaav5490 (2019). 10.1126/sciadv.aav5490

[31]

Jiao, L. et al. Single-atom catalysts boost signal amplification for biosensing. Chem. Soc. Rev. 50, 750–765 (2021). 10.1039/d0cs00367k

[32]

Wang, Z. et al. Accelerated discovery of superoxide-dismutase nanozymes via high-throughput computational screening. Nat. Commun. 12, 6866 (2021). 10.1038/s41467-021-27194-8

[33]

Zhong, M. et al. Accelerated discovery of CO2 electrocatalysts using active machine learning. Nature 581, 178–183 (2020). 10.1038/s41586-020-2242-8

[34]

McConnell, E. M. et al. Biosensing with DNAzymes. Chem. Soc. Rev. 50, 8954–8994 (2021). 10.1039/d1cs00240f

[35]

Borggräfe, J. et al. Time-resolved structural analysis of an RNA-cleaving DNA catalyst. Nature 601, 144–149 (2022). 10.1038/s41586-021-04225-4

[36]

Liu, K., Lat, P. K., Yu, H.-Z. & Sen, D. CLICK-17, a DNA enzyme that harnesses ultra-low concentrations of either Cu+ or Cu2+ to catalyze the azide–alkyne ‘click’ reaction in water. Nucleic Acids Res. 48, 7356–7370 (2020).

[37]

Liu, M. et al. Programming a topologically constrained DNA nanostructure into a sensor. Nat. Commun. 7, 12074 (2016). 10.1038/ncomms12074

[38]

Kang, D.-K. et al. Rapid detection of single bacteria in unprocessed blood using integrated comprehensive droplet digital detection. Nat. Commun. 5, 5427 (2014). 10.1038/ncomms6427

[39]

Shen, J., Liu, G., Han, Y. & Jin, W. Artificial channels for confined mass transport at the sub-nanometre scale. Nat. Rev. Mater. 6, 294–312 (2021). 10.1038/s41578-020-00268-7

[40]

de Angelis, F. et al. Breaking the diffusion limit with super-hydrophobic delivery of molecules to plasmonic nanofocusing SERS structures. Nat. Photon. 5, 682–687 (2011). 10.1038/nphoton.2011.222

[41]

Morales-Narváez, E., Guix, M., Medina-Sánchez, M., Mayorga-Martinez, C. C. & Merkoçi, A. Micromotor enhanced microarray technology for protein detection. Small 10, 2542–2548 (2014). 10.1002/smll.201303068

[42]

Lin, M. et al. Programmable engineering of a biosensing interface with tetrahedral DNA nanostructures for ultrasensitive DNA detection. Angew. Chem. 127, 2179–2183 (2015). 10.1002/ange.201410720

[43]

Zhang, P. et al. Ultrasensitive detection of circulating exosomes with a 3D-nanopatterned microfluidic chip. Nat. Biomed. Eng. 3, 438–451 (2019). 10.1038/s41551-019-0356-9

[44]

Rivnay, J. et al. Organic electrochemical transistors. Nat. Rev. Mater. 3, 17086 (2018). This review describes the evolution of organic electrochemical transistors, including their fabrication, various configurations and their ability to amplify biochemical signals. 10.1038/natrevmats.2017.86

[45]

Rivnay, J. et al. Organic electrochemical transistors with maximum transconductance at zero gate bias. Adv. Mater. 25, 7010–7014 (2013). 10.1002/adma.201303080

[46]

Pappa, A. M. et al. Direct metabolite detection with an n-type accumulation mode organic electrochemical transistor. Sci. Adv. 4, eaat0911 (2018). 10.1126/sciadv.aat0911

[47]

Liang, Y., Wu, C., Figueroa-Miranda, G., Offenhäusser, A. & Mayer, D. Amplification of aptamer sensor signals by four orders of magnitude via interdigitated organic electrochemical transistors. Biosens. Bioelectron. 144, 111668 (2019). 10.1016/j.bios.2019.111668

[48]

Ersman, P. A. et al. All-printed large-scale integrated circuits based on organic electrochemical transistors. Nat. Commun. 10, 5053 (2019). 10.1038/s41467-019-13079-4

[49]

Jarczewska, M., Rębiś, J., Górski, Ł. & Malinowska, E. Development of DNA aptamer-based sensor for electrochemical detection of C-reactive protein. Talanta 189, 45–54 (2018). 10.1016/j.talanta.2018.06.035

[50]

Reiber, T., Zavoiura, O., Dose, C. & Yushchenko, D. A. Fluorophore multimerization as an efficient approach towards bright protein labels. Eur. J. Org. Chem. 2021, 2817–2830 (2021). 10.1002/ejoc.202100117

Showing 50 of 204 references

Cited By

181

Unified model for force-frequency coefficient of different shape quartz

Lixia Ma, Qiang Zhou · 2026

International Journal of Mechanical...

Improving Clinical Diagnostics and Patient Care through Artificial Intelligence and Biosensor Technologies

Sylwia Baluta, Vishnu Suresh · 2026

ACS Omega

From reactive to proactive: Continuous protein monitoring for preventive health care

Jane M. Donnelly, Ryan A. Neff · 2025

Science

Printable molecule-selective core–shell nanoparticles for wearable and implantable sensing

Minqiang Wang, Cui Ye · 2025

Nature Materials

Molecularly Responsive Aptamer-Functionalized Hydrogel for Continuous Plasmonic Biomonitoring

Soohyun Park, Alice Gerber · 2025

Journal of the American Chemical So...

On-body electrochemical measurement of sweat lactate with the use of paper-based fluidics and 3D-printed flexible wearable biosensor

Gabriella Iula, Antonella Miglione · 2025

Analytical and Bioanalytical Chemis...

Aptamers-based wearable electrochemical sensors for continuous monitoring of biomarkers in vivo

Suhang Liu, Chuanjie Yao · 2025

Microsystems & Nanoengineering

Barriers to translating continuous monitoring technologies for preventative medicine

Jack Chen, Patricia Jastrzebska-Perfect · 2025

Nature Biomedical Engineering

Wide-range and high-accuracy wireless sensor with self-humidity compensation for real-time ammonia monitoring

Wen Lv, Jianhua Yang · 2024

Nature Communications

Metrics

181

Citations

204

References

Details

Published: May 11, 2023
Vol/Issue: 1(8)
Pages: 560-575
License: View

Authors

Department of Chemistry, Weinberg College of Arts & Sciences; Northwestern University; International Institute for Nanotechnology; Northwestern University

Cite This Article

Connor D. Flynn, Dingran Chang, Alam Mahmud, et al. (2023). Biomolecular sensors for advanced physiological monitoring. Nature Reviews Bioengineering, 1(8), 560-575. https://doi.org/10.1038/s44222-023-00067-z

Biomolecular sensors for advanced physiological monitoring

You May Also Like