The Epidemiological Study of Coxsackievirus A6 revealing Hand, Foot and Mouth Disease Epidemic patterns in Guangdong, China

Hanri Zeng; Jing Lu; Huanying Zheng; Lina Yi; Xue Guo; Leng Liu; Shannon Rutherford; Limei Sun; Xiaohua Tan; Hui Li; Changwen Ke; Jinyan Lin

doi:10.1038/srep10550

journal article Open Access May 21, 2015

The Epidemiological Study of Coxsackievirus A6 revealing Hand, Foot and Mouth Disease Epidemic patterns in Guangdong, China

Hanri Zeng Jing Lu

Huanying Zheng Lina Yi

Xue Guo

Leng Liu Shannon Rutherford Limei Sun Xiaohua Tan Hui Li

Changwen Ke

Jinyan Lin

Scientific Reports Vol. 5 No. 1 · Springer Science and Business Media LLC

View at Publisher Save 10.1038/srep10550

Abstract

AbstractEnterovirus A71 (EVA71) and Coxsackievirus A16 (CVA16) are regarded as the two major causative pathogens in hand, foot and mouth disease (HFMD) epidemics. However, CVA6, previously largely ignored, became the predominant pathogen in China in 2013. In this study, we describe the epidemiological trendsofCVA6 during the annual HFMD outbreaks from 2008 to 2013 in Guangdong, China. The study results show that CVA6 has been one of three major causative agents of HFMD epidemics since 2009. The periodic rotation and dominance of the three pathogens, EVA71, CVA16 and CVA6, may have contributed to the continuously increasing HFMD epidemics. Moreover, phylogenetic analysis of the VP1 gene shows that major circulating CVA6 strains collected from 2009 to 2013 are distinct from the earlier strains collected before 2009. In conclusion, the discovery from this research investigating epidemiological trends of CVA6 from 2008 to 2013 explains the possible pattern of the continuous HFMD epidemic in China. The etiological change pattern also highlights the need for improvement for pathogen surveillance and vaccine strategies for HFMD control in China.

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References

Details

Published: May 21, 2015
Vol/Issue: 5(1)
License: View

Authors

Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA.

H

Huanying Zheng

Guangdong Provincial Center for Disease Control and Prevention, Guangzhou, China

L

Lina Yi

Guangdong Provincial Institution of Public Health, Guangzhou, China; Guangdong Provincial Center for Disease Control and Prevention, Guangzhou, China

Department of Biochemistry and Molecular Biology, University of Chicago, Chicago, Illinois 60637, United States

C

Changwen Ke

Guangdong Provincial Center for Disease Control and Prevention, Guangzhou, China

J

Jinyan Lin

Cite This Article

Hanri Zeng, Jing Lu, Huanying Zheng, et al. (2015). The Epidemiological Study of Coxsackievirus A6 revealing Hand, Foot and Mouth Disease Epidemic patterns in Guangdong, China. Scientific Reports, 5(1). https://doi.org/10.1038/srep10550

The Epidemiological Study of Coxsackievirus A6 revealing Hand, Foot and Mouth Disease Epidemic patterns in Guangdong, China

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