Spillover and pandemic properties of zoonotic viruses with high host plasticity

Christine Kreuder Johnson; Peta L. Hitchens; Tierra Smiley Evans; Tracey Goldstein; Kate Thomas; Andrew Clements; Damien O. Joly; Nathan D. Wolfe; Peter Daszak; William B. Karesh; Jonna K. Mazet

doi:10.1038/srep14830

journal article Open Access Oct 07, 2015

Spillover and pandemic properties of zoonotic viruses with high host plasticity

Christine Kreuder Johnson Peta L. Hitchens

Tierra Smiley Evans Tracey Goldstein Kate Thomas Andrew Clements Damien O. Joly Nathan D. Wolfe Peter Daszak

William B. Karesh Jonna K. Mazet

Scientific Reports Vol. 5 No. 1 · Springer Science and Business Media LLC

View at Publisher Save 10.1038/srep14830

Abstract

AbstractMost human infectious diseases, especially recently emerging pathogens, originate from animals and ongoing disease transmission from animals to people presents a significant global health burden. Recognition of the epidemiologic circumstances involved in zoonotic spillover, amplification and spread of diseases is essential for prioritizing surveillance and predicting future disease emergence risk. We examine the animal hosts and transmission mechanisms involved in spillover of zoonotic viruses to date and discover that viruses with high host plasticity (i.e. taxonomically and ecologically diverse host range) were more likely to amplify viral spillover by secondary human-to-human transmission and have broader geographic spread. Viruses transmitted to humans during practices that facilitate mixing of diverse animal species had significantly higher host plasticity. Our findings suggest that animal-to-human spillover of new viruses that are capable of infecting diverse host species signal emerging disease events with higher pandemic potential in that these viruses are more likely to amplify by human-to-human transmission with spread on a global scale.

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Details

Published: Oct 07, 2015
Vol/Issue: 5(1)
License: View

Authors

C

Christine Kreuder Johnson

California Department of Conservation, California Geological Survey, Sacramento, California, U.S.A.

Cite This Article

Christine Kreuder Johnson, Peta L. Hitchens, Tierra Smiley Evans, et al. (2015). Spillover and pandemic properties of zoonotic viruses with high host plasticity. Scientific Reports, 5(1). https://doi.org/10.1038/srep14830

Spillover and pandemic properties of zoonotic viruses with high host plasticity

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