Dual-Modality Photoacoustic and Ultrasound Imaging System for Noninvasive Sentinel Lymph Node Detection in Patients with Breast Cancer

Alejandro Garcia-Uribe; Todd N. Erpelding; Arie Krumholz; Haixin Ke; Konstantin Maslov; Catherine Appleton; Julie A. Margenthaler; Lihong V. Wang

doi:10.1038/srep15748

journal article Open Access Oct 29, 2015

Dual-Modality Photoacoustic and Ultrasound Imaging System for Noninvasive Sentinel Lymph Node Detection in Patients with Breast Cancer

Alejandro Garcia-Uribe Todd N. Erpelding Arie Krumholz Haixin Ke Konstantin Maslov Catherine Appleton Julie A. Margenthaler Lihong V. Wang

Scientific Reports Vol. 5 No. 1 · Springer Science and Business Media LLC

View at Publisher Save 10.1038/srep15748

Abstract

AbstractThe detection of regional lymph node metastases is important in cancer staging as it guides the prognosis of the patient and the strategy for treatment. Sentinel lymph node biopsy (SLNB) is an accurate, less invasive alternative to axillary lymph node dissection. The sentinel lymph node hypothesis states that the pathological status of the axilla can be accurately predicted by determining the status of the first lymph nodes that drain from the primary tumor. Physicians use radio-labeled sulfur colloid and/or methylene blue dye to identify the SLN, which is most likely to contain metastatic cancer cells. However, the surgical procedure causes morbidity and associated expenses. To overcome these limitations, we developed a dual-modality photoacoustic and ultrasonic imaging system to noninvasively detect SLNs based on the accumulation of methylene blue dye. Ultimately, we aim to guide percutaneous needle biopsies and provide a minimally invasive method for axillary staging of breast cancer.

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Details

Published: Oct 29, 2015
Vol/Issue: 5(1)
License: View

Authors

A

Alejandro Garcia-Uribe

Julie A. Margenthaler

L

Lihong V. Wang

Cite This Article

Alejandro Garcia-Uribe, Todd N. Erpelding, Arie Krumholz, et al. (2015). Dual-Modality Photoacoustic and Ultrasound Imaging System for Noninvasive Sentinel Lymph Node Detection in Patients with Breast Cancer. Scientific Reports, 5(1). https://doi.org/10.1038/srep15748

Dual-Modality Photoacoustic and Ultrasound Imaging System for Noninvasive Sentinel Lymph Node Detection in Patients with Breast Cancer

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