Trends in presentation, management and survival of patients with de novo metastatic breast cancer in a Southeast Asian setting

Nirmala Bhoo-Pathy; Helena Marieke Verkooijen; Ern-Yu Tan; Hui Miao; Nur Aishah Mohd Taib; Judith S. Brand; Rebecca A. Dent; Mee-Hoong See; ShriDevi Subramaniam; Patrick Chan; Soo-Chin Lee; Mikael Hartman; Cheng-Har Yip

doi:10.1038/srep16252

journal article Open Access Nov 05, 2015

Trends in presentation, management and survival of patients with de novo metastatic breast cancer in a Southeast Asian setting

Nirmala Bhoo-Pathy Helena Marieke Verkooijen Ern-Yu Tan Hui Miao Nur Aishah Mohd Taib Judith S. Brand

Rebecca A. Dent Mee-Hoong See ShriDevi Subramaniam Patrick Chan Soo-Chin Lee Mikael Hartman

Cheng-Har Yip

Scientific Reports Vol. 5 No. 1 · Springer Science and Business Media LLC

View at Publisher Save 10.1038/srep16252

Abstract

AbstractUp to 25% of breast cancer patients in Asia present with de novo metastatic disease. We examined the survival trends of Asian patients with metastatic breast cancer over fifteen years. The impact of changes in patient’s demography, tumor characteristics, tumor burden and treatment on survival trend were examined. Patients with de novo metastatic breast cancer from three hospitals in Malaysia and Singapore (N = 856) were grouped by year of diagnosis: 1996–2000, 2001–2005 and 2006–2010. Step-wise multivariable Poisson regression was used to estimate the contribution of above-mentioned factors on the survival trend. Proportions of patients presenting with metastatic breast cancer were 10% in 1996–2000, 7% in 2001–2005 and 9% in 2006–2010. Patients in 2006–2010 were significantly older, appeared to have higher disease burden and received more chemotherapy, endocrine therapy and surgery of primary tumor. The three-year relative survival in the above periods were 20·6% (95% CI: 13·9%–28·2%), 28·8% (95% CI: 23·4%–34·2%) and 33·6% (95% CI: 28·8%–38·5%), respectively. Adjustment for treatment considerably attenuated the relative excess risk of mortality in recent years, compared to other factors. Substantial improvements in survival were observed in patients with de novo metastatic breast cancer in this study.

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Details

Published: Nov 05, 2015
Vol/Issue: 5(1)
License: View

Authors

N

Nirmala Bhoo-Pathy

H

Helena Marieke Verkooijen

Department of Bioengineering and The Whitaker Institute of Biomedical Engineering, University of California, San Diego, La Jolla, CA 92093-0427; Department of Vascular Biology, The Scripps Research Institute, La Jolla, CA 92037; and Division of Biomedical Sciences, University of California, Riverside, Riverside, CA 92521-0121

Associate Professor, Division of Medical Oncology, National Cancer Center Singapore, 11 Hospital Drive, 169610, Singapore; Duke-NUS Medical School, Singapore

Cancer Science Institute of Singapore, National University of Singapore, Singapore 117599, Singapore; National University Cancer Institute, Singapore 119074, Singapore; Department of Haematology-Oncology, National University Health System, Singapore 119228, Singapore

Department of Surgery, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia; Ramsay Sime Darby Health Care, Kuala Lumpur, Malaysia

Cite This Article

Nirmala Bhoo-Pathy, Helena Marieke Verkooijen, Ern-Yu Tan, et al. (2015). Trends in presentation, management and survival of patients with de novo metastatic breast cancer in a Southeast Asian setting. Scientific Reports, 5(1). https://doi.org/10.1038/srep16252

Trends in presentation, management and survival of patients with de novo metastatic breast cancer in a Southeast Asian setting

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