Resveratrol enhances HBV replication through activating Sirt1-PGC-1α-PPARα pathway

Yixian Shi; Yongjun Li; Chenjie Huang; Lixiong Ying; Jihua Xue; Haicong Wu; Zhenggang Yang

doi:10.1038/srep24744

journal article Open Access Apr 21, 2016

Resveratrol enhances HBV replication through activating Sirt1-PGC-1α-PPARα pathway

Yixian Shi Yongjun Li

Chenjie Huang Lixiong Ying Jihua Xue Haicong Wu Zhenggang Yang

Scientific Reports Vol. 6 No. 1 · Springer Science and Business Media LLC

View at Publisher Save 10.1038/srep24744

Abstract

AbstractThe population of hepatitis B combined with a number of metabolic disorders is increasing significantly. Resveratrol (RSV) has been used as a preclinical drug for the treatment of the metabolic disorders. However, the impact of RSV on HBV replication remains unknown. In this study, the HBV-expressing hepatocelluar carcinoma cell line and mouse model created by hydrodynamic injection of viral DNA were used. We found that RSV activates Sirt1, which in turn deacetylates PGC-1α and subsequently increases the transcriptional activity of PPARα, leading to the enhanced HBV transcription and replication in vitro and in vivo. In addition, we found that this pathway is also required for fasting-induced HBV transcription. Taken together, this study identifies that RSV enhances HBV transcription and replication especially acting on the core promoter, which depends on Sirt1-PGC-1α-PPARα pathway. We conclude that RSV may exacerbate the progression of hepatitis B and that patients with hepatitis B infection should be cautious taking RSV as a dietary supplement.

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Details

Published: Apr 21, 2016
Vol/Issue: 6(1)
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Authors

Department of Hepatology, Hepatology Research Institute, The First Affiliated Hospital of Fujian Medical University, Fuzhou, Fujian Province, China; Department of Gastroenterology, The Seventh Affiliated Hospital of Southern Medical University, Foshan, China; National Clinical Research Center for Digestive Diseases, Changhai Hospital, Fuzhou, Fujian, China

Z

Zhenggang Yang

Cite This Article

Yixian Shi, Yongjun Li, Chenjie Huang, et al. (2016). Resveratrol enhances HBV replication through activating Sirt1-PGC-1α-PPARα pathway. Scientific Reports, 6(1). https://doi.org/10.1038/srep24744

Resveratrol enhances HBV replication through activating Sirt1-PGC-1α-PPARα pathway

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