A serum 6-miRNA panel as a novel non-invasive biomarker for meningioma

Feng Zhi; Naiyuan Shao; Bowen Li; Lian Xue; Danni Deng; Yuan Xu; Qing Lan; Ya Peng; Yilin Yang

doi:10.1038/srep32067

journal article Open Access Aug 25, 2016

A serum 6-miRNA panel as a novel non-invasive biomarker for meningioma

Feng Zhi Naiyuan Shao Bowen Li

Lian Xue

Danni Deng Yuan Xu

Qing Lan Ya Peng Yilin Yang

Scientific Reports Vol. 6 No. 1 · Springer Science and Business Media LLC

View at Publisher Save 10.1038/srep32067

Abstract

AbstractCirculating microRNAs (miRNAs) hold great promise as novel clinically blood-based biomarkers for cancer diagnosis and prognosis. However, little is known about their impact in meningioma. The TLDA assay was performed as an initial survey to determine the serum miRNA expression profile in two pooled samples from 20 pre-operative meningiomas and 20 matched healthy controls. Selected candidate miRNAs were subsequently validated individually in another 210 patients and 210 healthy controls from two independent cohorts by qRT-PCR. The serum levels of miR-106a-5p, miR-219-5p, miR-375 and miR-409-3p were significantly increased, whereas the serum levels of miR-197 and miR-224 were markedly decreased. The area under the ROC curve (AUC) for the six combined miRNAs was 0.778. The 4 increased miRNAs were significantly decreased, while the 2 decreased miRNAs were significantly increased after tumor removal. Furthermore, the expression levels of miR-224 were associated with sex and the expression levels of miR-219-5p were positively associated with the clinical stages of meningioma. Finally, the high expression of miR-409-3p and low expression of miR-224 were significantly correlated with higher recurrence rates. The present study revealed that the panel of 6 serum miRNA may have the potential to be used clinically as an auxiliary tool for meningioma patients.

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Published: Aug 25, 2016
Vol/Issue: 6(1)
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Cite This Article

Feng Zhi, Naiyuan Shao, Bowen Li, et al. (2016). A serum 6-miRNA panel as a novel non-invasive biomarker for meningioma. Scientific Reports, 6(1). https://doi.org/10.1038/srep32067

A serum 6-miRNA panel as a novel non-invasive biomarker for meningioma

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