Optimization of Treatment Geometry to Reduce Normal Brain Dose in Radiosurgery of Multiple Brain Metastases with Single–Isocenter Volumetric Modulated Arc Therapy

Qixue Wu; Karen Chin Snyder; Chang Liu; Bo Zhao; Indrin J. Chetty; Ning Wen

doi:10.1038/srep34511

journal article Open Access Sep 30, 2016

Optimization of Treatment Geometry to Reduce Normal Brain Dose in Radiosurgery of Multiple Brain Metastases with Single–Isocenter Volumetric Modulated Arc Therapy

Qixue Wu Karen Chin Snyder Chang Liu

Bo Zhao

Indrin J. Chetty Ning Wen

Scientific Reports Vol. 6 No. 1 · Springer Science and Business Media LLC

View at Publisher Save 10.1038/srep34511

Abstract

AbstractTreatment of patients with multiple brain metastases using a single-isocenter volumetric modulated arc therapy (VMAT) has been shown to decrease treatment time with the tradeoff of larger low dose to the normal brain tissue. We have developed an efficient Projection Summing Optimization Algorithm to optimize the treatment geometry in order to reduce dose to normal brain tissue for radiosurgery of multiple metastases with single-isocenter VMAT. The algorithm: (a) measures coordinates of outer boundary points of each lesion to be treated using the Eclipse Scripting Application Programming Interface, (b) determines the rotations of couch, collimator and gantry using three matrices about the cardinal axes, (c) projects the outer boundary points of the lesion on to Beam Eye View projection plane, (d) optimizes couch and collimator angles by selecting the least total unblocked area for each specific treatment arc and (e) generates a treatment plan with the optimized angles. The results showed significant reduction in the mean dose and low dose volume to normal brain, while maintaining the similar treatment plan qualities on the thirteen patients treated previously. The algorithm has the flexibility with regard to the beam arrangements and can be integrated in the treatment planning system for clinical application directly.

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Details

Published: Sep 30, 2016
Vol/Issue: 6(1)
License: View

Authors

Universiti Malaysia Kelantan

Department of Radiation Oncology Cedars Sinai Medical Center Los Angeles California USA

N

Ning Wen

National Engineering Research Center for Colloidal Materials, School of Chemistry and Chemical Engineering, Shandong University, 250100, Jinan, Shandong, China

Cite This Article

Qixue Wu, Karen Chin Snyder, Chang Liu, et al. (2016). Optimization of Treatment Geometry to Reduce Normal Brain Dose in Radiosurgery of Multiple Brain Metastases with Single–Isocenter Volumetric Modulated Arc Therapy. Scientific Reports, 6(1). https://doi.org/10.1038/srep34511

Optimization of Treatment Geometry to Reduce Normal Brain Dose in Radiosurgery of Multiple Brain Metastases with Single–Isocenter Volumetric Modulated Arc Therapy

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