Metabolic response induced by parasitic plant-fungus interactions hinder amino sugar and nucleotide sugar metabolism in the host

Dong-Kyu Lee; Soohyun Ahn; Hae Yoon Cho; Hye Young Yun; Jeong Hill Park; Johan Lim; Jeongmi Lee; Sung Won Kwon

doi:10.1038/srep37434

journal article Open Access Nov 28, 2016

Metabolic response induced by parasitic plant-fungus interactions hinder amino sugar and nucleotide sugar metabolism in the host

Dong-Kyu Lee Soohyun Ahn Hae Yoon Cho Hye Young Yun Jeong Hill Park Johan Lim Jeongmi Lee

Sung Won Kwon

Scientific Reports Vol. 6 No. 1 · Springer Science and Business Media LLC

View at Publisher Save 10.1038/srep37434

Abstract

AbstractInfestation by the biotrophic pathogen Gymnosporangium asiaticum can be devastating for plant of the family Rosaceae. However, the phytopathology of this process has not been thoroughly elucidated. Using a metabolomics approach, we discovered the intrinsic activities that induce disease symptoms after fungal invasion in terms of microbe-induced metabolic responses. Through metabolic pathway enrichment and mapping, we found that the host altered its metabolite levels, resulting in accumulation of tetrose and pentose sugar alcohols, in response to this fungus. We then used a multiple linear regression model to evaluate the effect of the interaction between this abnormal accumulation of sugar alcohol and the group variable (control/parasitism). The results revealed that this accumulation resulted in deficiency in the supply of specific sugars, which led to a lack of amino sugar and nucleotide sugar metabolism. Halting this metabolism could hamper pivotal functions in the plant host, including cell wall synthesis and lesion repair. In conclusion, our findings indicate that altered metabolic responses that occur during fungal parasitism can cause deficiency in substrates in pivotal pathways and thereby trigger pathological symptoms.

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Published: Nov 28, 2016
Vol/Issue: 6(1)
License: View

Authors

D

Dong-Kyu Lee

Research Institute of Pharmaceutical Sciences, Seoul National University, Seoul, Republic of Korea

S

Soohyun Ahn

Department of Mathematics,Ajou University,Suwon,Republic of Korea

College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University, Seoul 08826, Korea

J

Johan Lim

Department of Statistics, Seoul National University, Seoul 08826, Korea

J

Jeongmi Lee

School of Pharmacy, Sungkyunkwan University, Suwon 16419, Korea.

S

Sung Won Kwon

Cite This Article

Dong-Kyu Lee, Soohyun Ahn, Hae Yoon Cho, et al. (2016). Metabolic response induced by parasitic plant-fungus interactions hinder amino sugar and nucleotide sugar metabolism in the host. Scientific Reports, 6(1). https://doi.org/10.1038/srep37434

Metabolic response induced by parasitic plant-fungus interactions hinder amino sugar and nucleotide sugar metabolism in the host

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