25(OH)D and 1,25(OH)D vitamin D fails to predict sepsis and mortality in a prospective cohort study

Franz Ratzinger; Helmuth Haslacher; Markus Stadlberger; Ralf L. J. Schmidt; Markus Obermüller; Klaus G. Schmetterer; Thomas Perkmann; Athanasios Makristathis; Rodrig Marculescu; Heinz Burgmann

doi:10.1038/srep40646

journal article Open Access Jan 12, 2017

25(OH)D and 1,25(OH)D vitamin D fails to predict sepsis and mortality in a prospective cohort study

Franz Ratzinger Helmuth Haslacher Markus Stadlberger Ralf L. J. Schmidt Markus Obermüller Klaus G. Schmetterer Thomas Perkmann Athanasios Makristathis Rodrig Marculescu

Heinz Burgmann

Scientific Reports Vol. 7 No. 1 · Springer Science and Business Media LLC

View at Publisher Save 10.1038/srep40646

Abstract

AbstractThe clinical role of vitamin D in sepsis and mortality prediction is controversially discussed. Therefore, we conducted a prospective cohort study on standard care wards, including 461 patients with suspected sepsis fulfilling two or more SIRS criteria. On the first and third day after onset of SIRS symptoms levels of 25(OH)D, 1,25(OH)D and sepsis biomarkers were analysed for their predictive capacity for identifying infection, bacteraemia and an elevated mortality risk. Additionally, several SNPs associated with vitamin D metabolism were evaluated. Bacteraemic patients (28.5%) presented with significantly lower 1,25(OH)D levels than SIRS patients without bacteraemia on the first and third day, while 25(OH)D did not show a predictive capacity. No significant differences of either 1,25(OH)D or 25(OH)D levels were found between SIRS patients with and without infections or between survivors and non-survivors. Sepsis biomarkers, including procalcitonin and CRP, showed a significantly higher discriminatory capacity for these classification tasks. The vitamin D metabolism-related SNPs analysed did not indicate any association with our outcome measures. In conclusion, 1,25(OH)D but not 25(OH)D showed a minor discriminatory value for the prediction of bacteraemia that was inferior to CRP and PCT but both failed to predict sepsis and mortality in a prospective cohort of SIRS patients.

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Details

Published: Jan 12, 2017
Vol/Issue: 7(1)
License: View

Authors

Athanasios Makristathis

Cite This Article

Franz Ratzinger, Helmuth Haslacher, Markus Stadlberger, et al. (2017). 25(OH)D and 1,25(OH)D vitamin D fails to predict sepsis and mortality in a prospective cohort study. Scientific Reports, 7(1). https://doi.org/10.1038/srep40646

25(OH)D and 1,25(OH)D vitamin D fails to predict sepsis and mortality in a prospective cohort study

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