Neural networks underlying implicit and explicit moral evaluations in psychopathy

K J Yoder; C Harenski; K A Kiehl; J Decety

doi:10.1038/tp.2015.117

journal article Open Access Aug 25, 2015

Neural networks underlying implicit and explicit moral evaluations in psychopathy

K J Yoder C Harenski K A Kiehl J Decety

Translational Psychiatry Vol. 5 No. 8 pp. e625-e625 · Springer Science and Business Media LLC

View at Publisher Save 10.1038/tp.2015.117

Abstract

AbstractPsychopathy, characterized by symptoms of emotional detachment, reduced guilt and empathy and a callous disregard for the rights and welfare of others, is a strong risk factor for immoral behavior. Psychopathy is also marked by abnormal attention with downstream consequences on emotional processing. To examine the influence of task demands on moral evaluation in psychopathy, functional magnetic resonance imaging was used to measure neural response and functional connectivity in 88 incarcerated male subjects (28 with Psychopathy Checklist Revised (PCL-R) scores ⩾30) while they viewed dynamic visual stimuli depicting interpersonal harm and interpersonal assistance in two contexts, implicit and explicit. During the implicit task, high psychopathy was associated with reduced activity in the dorsolateral prefrontal cortex and caudate when viewing harmful compared with helpful social interactions. Functional connectivity seeded in the right amygdala and right temporoparietal junction revealed decreased coupling with the anterior cingulate cortex (ACC), anterior insula, striatum and ventromedial prefrontal cortex. In the explicit task, higher trait psychopathy predicted reduced signal change in ACC and amygdala, accompanied by decreased functional connectivity to temporal pole, insula and striatum, but increased connectivity with dorsal ACC. Psychopathy did not influence behavioral performance in either task, despite differences in neural activity and functional connectivity. These findings provide the first direct evidence that hemodynamic activity and neural coupling within the salience network are disrupted in psychopathy, and that the effects of psychopathy on moral evaluation are influenced by attentional demands.

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References

83

[1]

Hare RD, Neumann CS . Psychopathy as a clinical and empirical construct. Annu Rev Clin Psychol 2008; 4: 217–246. 10.1146/annurev.clinpsy.3.022806.091452

[2]

Kiehl KA . The Psychopath Whisperer: Inside the Minds of Those Without a Conscience. Crown Publishers: New York, NY, 2014.

[3]

Anderson NE, Kiehl KA . The psychopath magnetized: insights from brain imaging. Trends Cogn Sci 2012; 16: 52–60. 10.1016/j.tics.2011.11.008

[4]

Koenigs M, Baskin-Sommers A, Zeier J, Newman JP . Investigating the neural correlates of psychopathy: a critical review. Mol Psychiatry 2011; 16: 792–799. 10.1038/mp.2010.124

[5]

Brook M, Brieman CL, Kosson DS . Emotion processing in Psychopathy Checklist - assessed psychopathy: a review of the literature. Clin Psychol Rev 2013; 33: 979–995. 10.1016/j.cpr.2013.07.008

[6]

Decety J, Skelly LR, Kiehl KA . Brain response to empathy-eliciting scenarios involving pain in incarcerated individuals with psychopathy. JAMA Psychiatry 2013; 70: 638–645. 10.1001/jamapsychiatry.2013.27

[7]

Decety J, Skelly L, Yoder KJ, Kiehl KA . Neural processing of dynamic emotional facial expressions in psychopaths. Soc Neurosci 2014; 9: 36–49. 10.1080/17470919.2013.866905

[8]

Kiehl KA, Smith AM, Hare RD, Mendrek A, Forster BB, Brink J et al. Limbic abnormalities in affective processing by criminal psychopaths as revealed by functional magnetic resonance imaging. Biol Psychiatry 2001; 50: 677–684. 10.1016/s0006-3223(01)01222-7

[9]

Seara-Cardoso A, Viding E . Functional neuroscience of psychopathic personality in adults. J Pers 2014; : 1–15. 10.3758/s13415-015-0346-7

[10]

Seeley WW, Menon V, Schatzberg AF, Keller J, Glover GH, Kenna H et al. Dissociable intrinsic connectivity networks for salience processing and executive control. J Neurosci 2007; 27: 2349–2356. 10.1523/jneurosci.5587-06.2007

[11]

Haidt J . The emotional dog and its rational tail: a social intuitionist approach to moral judgment. Psychol Rev 2001; 108: 814–834. 10.1037/0033-295x.108.4.814

[12]

The complex relation between morality and empathy

Jean Decety, Jason M. Cowell

Trends in Cognitive Sciences 2014 10.1016/j.tics.2014.04.008

[13]

Landy JF, Goodwin GP . Does incidental disgust amplify moral judgment? A meta-analytic review of experimental evidence. Perspect Psychol Sci 2015; 10: 518–536. 10.1177/1745691615583128

[14]

Maibom HL . Feeling for others: empathy, sympathy, and morality. Inquiry 2009; 52: 483–499. 10.1080/00201740903302626

[15]

Greene JD, Nystrom LE, Engell AD, Darley JM, Cohen JD . The neural bases of cognitive conflict and control in moral judgment. Neuron 2004; 44: 389–400. 10.1016/j.neuron.2004.09.027

[16]

Rosas A, Koenigs M . Beyond ‘utilitarianism’: maximizing the clinical impact of moral judgment research. Soc Neurosci 2014; 9: 661–667.

[17]

Book AS, Quinsey VL, Langford DJ . Psychopathy and the perception of affect and vulnerability. Crim Justice Behav 2007; 34: 531–544. 10.1177/0093854806293554

[18]

Maibom HL . The mad, the bad, and the psychopath. Neuroethics 2008; 1: 167–184. 10.1007/s12152-008-9013-9

[19]

Brook M, Kosson DS . Impaired cognitive empathy in criminal psychopathy: evidence from a laboratory measure of empathic accuracy. J Abnorm Psychol 2013; 122: 156–166. 10.1037/a0030261

[20]

Gao Y, Tang S . Psychopathic personality and utilitarian moral judgment in college students. J Crim Justice 2013; 41: 342–349. 10.1016/j.jcrimjus.2013.06.012

[21]

Glenn AL, Koleva S, Iyer R, Graham J, Ditto PH . Moral identity in psychopathy. Judgm Decis Mak 2010; 5: 497–505. 10.1017/s1930297500001662

[22]

Koenigs M, Young L, Adolphs R, Tranel D, Cushman F, Hauser M et al. Damage to the prefrontal cortex increases utilitarian moral judgements. Nature 2007; 446: 908–911. 10.1038/nature05631

[23]

Taber-Thomas BC, Asp EW, Koenigs M, Sutterer M, Anderson SW, Tranel D . Arrested development: early prefrontal lesions impair the maturation of moral judgement. Brain 2014; 137: 1254–1261. 10.1093/brain/awt377

[24]

Thomas BC, Croft KE, Tranel D . Harming kin to save strangers: further evidence for abnormally utilitarian moral judgments after ventromedial prefrontal damage. J Cogn Neurosci 2011; 23: 2186–2196. 10.1162/jocn.2010.21591

[25]

Koenigs M, Kruepke M, Zeier J, Newman JP . Utilitarian moral judgment in psychopathy. Soc Cogn Affect Neurosci 2012; 7: 708–714. 10.1093/scan/nsr048

[26]

Glenn AL, Raine A, Schug RA, Young L, Hauser M . Increased DLPFC activity during moral decision-making in psychopathy. Mol Psychiatry 2009; 14: 909–911. 10.1038/mp.2009.76

[27]

Cima M, Tonnaer F, Hauser MD . Psychopaths know right from wrong but don’t care. Soc Cogn Affect Neurosci 2010; 5: 59–67. 10.1093/scan/nsp051

[28]

Blair RJR . Moral judgment and psychopathy. Emot Rev 2011; 3: 296–298. 10.1177/1754073911406297

[29]

Decety J, Michalska KJ, Kinzler KD . The contribution of emotion and cognition to moral sensitivity: a neurodevelopmental study. Cereb Cortex 2012; 22: 209–220. 10.1093/cercor/bhr111

[30]

Bechara A, Damasio AR . The somatic marker hypothesis: a neural theory of economic decision. Games Econ Behav 2005; 52: 336–372. 10.1016/j.geb.2004.06.010

[31]

Moll J, De Oliveira-Souza R, Zahn R . The neural basis of moral cognition: sentiments, concepts, and values. Ann N Y Acad Sci 2008; 1124: 161–180. 10.1196/annals.1440.005

[32]

Sobhani M, Bechara A . A somatic marker perspective of immoral and corrupt behavior. Soc Neurosci 2011; 6: 640–652. 10.1080/17470919.2011.605592

[33]

Blair RJR . The amygdala and ventromedial prefrontal cortex in morality and psychopathy. Trends Cogn Sci 2007; 11: 387–392. 10.1016/j.tics.2007.07.003

[34]

Poppa T, Bechara A . A neural perspective on immoral behavior and psychopathy. Am J Bioeth Neurosci 2015; 6: 640–652.

[35]

Ayob G, Thornton T . Psychopathy: what apology making tells us about moral agency. Theor Med Bioeth 2014; 35: 17–29. 10.1007/s11017-014-9279-3

[36]

Harenski CL, Harenski KA, Shane MS, Kiehl KA . Aberrant neural processing of moral violations in criminal psychopaths. J Abnorm Psychol 2010; 119: 863–874. 10.1037/a0020979

[37]

Kahane G . Sidetracked by trolleys: why sacrificial moral dilemmas tell us little (or nothing) about utilitarian judgment. Soc Neurosci 2015; : 1–10. 10.1080/17470919.2015.1023400

[38]

Intrator J, Hare R, Stritzke P, Brichtswein K, Dorfman D, Harpur T et al. A brain imaging (single photon emission computerized tomography) study of semantic and affective processing in psychopaths. Biol Psychiatry 1997; 42: 96–103. 10.1016/s0006-3223(96)00290-9

[39]

Haidt J, Kesebir S . Morality. In: Fiske ST, Gilbert D, Lindzey G (eds) Handbook of Social Psychology. 5th edn, Wiley: Hoboken, NJ. USA, 2010 pp 797–832.

[40]

Pessoa L . On the relationship between emotion and cognition. Nat Rev Neurosci 2008; 9: 148–158. 10.1038/nrn2317

[41]

Bressler SL, Menon V . Large-scale brain networks in cognition: emerging methods and principles. Trends Cogn Sci 2010; 14: 277–290. 10.1016/j.tics.2010.04.004

[42]

Cushman F, Young L, Hauser M . The role of conscious reasoning and intuition in moral judgment: testing three principles of harm. Psychol Sci 2006; 17: 1082–1089. 10.1111/j.1467-9280.2006.01834.x

[43]

Young L, Dungan J . Where in the brain is morality? Everywhere and maybe nowhere. Soc Neurosci 2012; 7: 1–10. 10.1080/17470919.2011.569146

[44]

Harsay HA, Spaan M, Wijnen JG, Ridderinkhof KR . Error awareness and salience processing in the oddball task: shared neural mechanisms. Front Hum Neurosci 2012; 6: 246. 10.3389/fnhum.2012.00246

[45]

Bzdok D, Schilbach L, Vogeley K, Schneider K, Laird AR, Langner R et al. Parsing the neural correlates of moral cognition: ALE meta-analysis on morality, theory of mind, and empathy. Brain Struct Funct 2012; 217: 783–796. 10.1007/s00429-012-0380-y

[46]

Silani G, Lamm C, Ruff CC, Singer T . Right supramarginal gyrus is crucial to overcome emotional egocentricity bias in social judgments. J Neurosci 2013; 33: 15466–15476. 10.1523/jneurosci.1488-13.2013

[47]

Decety J, Cacioppo S . The speed of morality: a high-density electrical neuroimaging study. J Neurophysiol 2012; 108: 3068–3072. 10.1152/jn.00473.2012

[48]

Decety J, Chen C, Harenski CL, Kiehl KA . Socioemotional processing of morally-laden behavior and their consequences on others in forensic psychopaths. Hum Brain Mapp 2015; 36: 2015–2026. 10.1002/hbm.22752

[49]

Yoder KJ, Decety J . The good, the bad, and the just: Justice sensitivity predicts neural response during moral evaluation of actions performed by others. J Neurosci 2014; 34: 4161–4166. 10.1523/jneurosci.4648-13.2014

[50]

Young L, Saxe R . The neural basis of belief encoding and integration in moral judgment. Neuroimage 2008; 40: 1912–1920. 10.1016/j.neuroimage.2008.01.057

Showing 50 of 83 references

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Details

Published: Aug 25, 2015
Vol/Issue: 5(8)
Pages: e625-e625
License: View

Authors

Cite This Article

K J Yoder, C Harenski, K A Kiehl, et al. (2015). Neural networks underlying implicit and explicit moral evaluations in psychopathy. Translational Psychiatry, 5(8), e625-e625. https://doi.org/10.1038/tp.2015.117

Neural networks underlying implicit and explicit moral evaluations in psychopathy

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