Total synthesis and stereochemical revision of xiamenmycin A

Xiaozhen Jiao; Yangyang Yao; Beibei Yang; Xiaoyu Liu; Hongguang Yang; Li Li; Jun Xu; Minjuan Xu; Ping Xie

doi:10.1039/c5ob02476e

journal article Jan 01, 2016

Total synthesis and stereochemical revision of xiamenmycin A

Xiaozhen Jiao Yangyang Yao Beibei Yang

Xiaoyu Liu

Hongguang Yang Li Li

Jun Xu

Minjuan Xu Ping Xie

Organic & Biomolecular Chemistry Vol. 14 No. 5 pp. 1805-1813 · Royal Society of Chemistry (RSC)

View at Publisher Save 10.1039/c5ob02476e

Abstract

The relative and absolute configurations of xiamenmycin A, a benzopyran compound isolated from Streptomyces xiamenensis 318 with a highly potent anti-fibrotic activity, have been characterized through the total synthesis.

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Details

Published: Jan 01, 2016
Vol/Issue: 14(5)
Pages: 1805-1813

Authors

X

Xiaozhen Jiao

State Key Laboratory of Bioactive Substances and Functions of Natural Medicines; Institute of Materia Medica; Beijing Key Laboratory of Active Substances Discovery and Drugability Evaluation; Peking Union Medical College and Chinese Academy of Medical Sciences; Beijing 100050

Y

Yangyang Yao

State Key Laboratory of Bioactive Substances and Functions of Natural Medicines; Institute of Materia Medica; Beijing Key Laboratory of Active Substances Discovery and Drugability Evaluation; Peking Union Medical College and Chinese Academy of Medical Sciences; Beijing 100050

B

Beibei Yang

State Key Laboratory of Bioactive Substances and Functions of Natural Medicines; Institute of Materia Medica; Beijing Key Laboratory of Active Substances Discovery and Drugability Evaluation; Peking Union Medical College and Chinese Academy of Medical Sciences; Beijing 100050

X

Xiaoyu Liu

State Key Laboratory of Bioactive Substances and Functions of Natural Medicines; Institute of Materia Medica; Beijing Key Laboratory of Active Substances Discovery and Drugability Evaluation; Peking Union Medical College and Chinese Academy of Medical Sciences; Beijing 100050

H

Hongguang Yang

State Key Laboratory of Bioactive Substances and Functions of Natural Medicines; Institute of Materia Medica; Beijing Key Laboratory of Active Substances Discovery and Drugability Evaluation; Peking Union Medical College and Chinese Academy of Medical Sciences; Beijing 100050

L

Li Li

State Key Laboratory of Bioactive Substances and Functions of Natural Medicines; Institute of Materia Medica; Beijing Key Laboratory of Active Substances Discovery and Drugability Evaluation; Peking Union Medical College and Chinese Academy of Medical Sciences; Beijing 100050

J

Jun Xu

Institute of Oceanology and State Key Laboratory of Microbial Metabolism; Shanghai Jiao Tong University; Shanghai 200240; PR China

M

Minjuan Xu

Key Laboratory of Systems Biomedicine; Shanghai Center for Systems Biomedicine; Shanghai Jiao Tong University; Shanghai 200240; PR China

P

Ping Xie

State Key Laboratory of Bioactive Substances and Functions of Natural Medicines; Institute of Materia Medica; Beijing Key Laboratory of Active Substances Discovery and Drugability Evaluation; Peking Union Medical College and Chinese Academy of Medical Sciences; Beijing 100050

Funding

National Natural Science Foundation of China Award: No. 81102321, 81473105

Cite This Article

Xiaozhen Jiao, Yangyang Yao, Beibei Yang, et al. (2016). Total synthesis and stereochemical revision of xiamenmycin A. Organic & Biomolecular Chemistry, 14(5), 1805-1813. https://doi.org/10.1039/c5ob02476e

Total synthesis and stereochemical revision of xiamenmycin A

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