Copper-catalyzed retro-aldol reaction of β-hydroxy ketones or nitriles with aldehydes: chemo- and stereoselective access to (E)-enones and (E)-acrylonitriles

Song-Lin Zhang; Zhu-Qin Deng

doi:10.1039/c6ob01198e

journal article Jan 01, 2016

Copper-catalyzed retro-aldol reaction of β-hydroxy ketones or nitriles with aldehydes: chemo- and stereoselective access to (E)-enones and (E)-acrylonitriles

Song-Lin Zhang Zhu-Qin Deng

Organic & Biomolecular Chemistry Vol. 14 No. 30 pp. 7282-7294 · Royal Society of Chemistry (RSC)

View at Publisher Save 10.1039/c6ob01198e

Abstract

A mild and efficient copper-catalyzed retro-aldol reaction of β-hydroxy ketones or nitriles with benzaldehydes produces chemo-, regio- and stereoselectively (E)-enones and (E)-acrylonitriles.

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Details

Published: Jan 01, 2016
Vol/Issue: 14(30)
Pages: 7282-7294

Authors

S

Song-Lin Zhang

The Key Laboratory of Food Colloids and Biotechnology; Ministry of Education; School of Chemical and Material Engineering; Jiangnan University; Wuxi 214122

Z

Zhu-Qin Deng

The Key Laboratory of Food Colloids and Biotechnology; Ministry of Education; School of Chemical and Material Engineering; Jiangnan University; Wuxi 214122

Funding

National Natural Science Foundation of China Award: 21472068,21202062

National Natural Science Foundation of Jiangsu Province Award: BK2012108

Cite This Article

Song-Lin Zhang, Zhu-Qin Deng (2016). Copper-catalyzed retro-aldol reaction of β-hydroxy ketones or nitriles with aldehydes: chemo- and stereoselective access to (E)-enones and (E)-acrylonitriles. Organic & Biomolecular Chemistry, 14(30), 7282-7294. https://doi.org/10.1039/c6ob01198e

Copper-catalyzed retro-aldol reaction of β-hydroxy ketones or nitriles with aldehydes: chemo- and stereoselective access to (E)-enones and (E)-acrylonitriles

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