Toxicological effects of patulin mycotoxin on the mammalian system: an overview

Saurabh Pal; Neha Singh; Kausar Mahmood Ansari

doi:10.1039/c7tx00138j

journal article Sep 04, 2017

Toxicological effects of patulin mycotoxin on the mammalian system: an overview

Saurabh Pal

Neha Singh

Kausar Mahmood Ansari

Toxicology Research Vol. 6 No. 6 pp. 764-771 · Oxford University Press (OUP)

View at Publisher Save 10.1039/c7tx00138j

Abstract

AbstractThe mycotoxin PAT (4-hydroxy-4H-furo[3,2c]pyran-2[6H]-one) is a secondary metabolic product of molds such as Penicillium, Aspergillus, and Byssochlamys species. PAT is a common contaminant of fruit and vegetable based products, most notably apples. Despite PAT's original discovery as an antibiotic, it has come under heavy scrutiny for its potential to impart negative health effects. Studies investigating these health effects have proved its toxic potential. PAT occurrence in the food commodities poses a serious threat and necessitates novel and cost-effective mitigation methods to remove it from food products. It also creates a demand to improve handling and food processing techniques. With this being the case, several studies have been devoted to understanding the key biological and chemical attributes of PAT. While past research has elucidated a great deal, PAT contamination continues to be a challenge for the food industry. Here, we review its influence within the mammalian system, including its regulation, incidences of experimental evidence of PAT toxicity, its interaction with intracellular components, and the effects of PAT induced systemic toxicity on vital organs. Finally, key areas where future PAT research should focus to best control the PAT contamination problem within the food industry have been addressed.

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Toxins

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References

Details

Published: Sep 04, 2017
Vol/Issue: 6(6)
Pages: 764-771
License: View

Authors

S

Saurabh Pal

Environmental Carcinogenesis Laboratory, Food, Drug, and Chemical Toxicology Group CSIR-Indian Institute of Toxicology Research (CSIR-IITR), Vishvigyan Bhawan, 31, Mahatma Gandhi Marg, P.O. Box#80, Lucknow-226001, Uttar Pradesh, India. Fax: +91-522-2628227; Tel: +91-522-2627586 ext. 543; Academy of Scientific and Innovative Research (AcSIR), CSIR-IITR, Lucknow Campus, India

N

Neha Singh

Environmental Carcinogenesis Laboratory, Food, Drug, and Chemical Toxicology Group CSIR-Indian Institute of Toxicology Research (CSIR-IITR), Vishvigyan Bhawan, 31, Mahatma Gandhi Marg, P.O. Box#80, Lucknow-226001, Uttar Pradesh, India. Fax: +91-522-2628227; Tel: +91-522-2627586 ext. 543; Academy of Scientific and Innovative Research (AcSIR), CSIR-IITR, Lucknow Campus, India

K

Kausar Mahmood Ansari

Environmental Carcinogenesis Laboratory, Food, Drug, and Chemical Toxicology Group CSIR-Indian Institute of Toxicology Research (CSIR-IITR), Vishvigyan Bhawan, 31, Mahatma Gandhi Marg, P.O. Box#80, Lucknow-226001, Uttar Pradesh, India. Fax: +91-522-2628227; Tel: +91-522-2627586 ext. 543

Funding

Department of Biotechnology , Ministry of Science and Technology Award: EMR/2015/000983

Department of Biotechnology, Ministry of Science and Technology Award: EMR/2015/000983

Cite This Article

Saurabh Pal, Neha Singh, Kausar Mahmood Ansari (2017). Toxicological effects of patulin mycotoxin on the mammalian system: an overview. Toxicology Research, 6(6), 764-771. https://doi.org/10.1039/c7tx00138j

Toxicological effects of patulin mycotoxin on the mammalian system: an overview

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