Degradable polymer prodrugs with adjustable activity from drug-initiated radical ring-opening copolymerization

Elise Guégain; Johanna Tran; Quentin Deguettes; Julien Nicolas

doi:10.1039/c8sc02256a

journal article Open Access Jan 01, 2018

Degradable polymer prodrugs with adjustable activity from drug-initiated radical ring-opening copolymerization

Elise Guégain

Johanna Tran Quentin Deguettes Julien Nicolas

Chemical Science Vol. 9 No. 43 pp. 8291-8306 · Royal Society of Chemistry (RSC)

View at Publisher Save 10.1039/c8sc02256a

Abstract

Degradable polymer prodrugs were synthesized by ‘drug-initiated’ nitroxide-mediated radical ring-opening copolymerization and led to either nanoparticles or soluble prodrugs with adjustable cytotoxicity on two different cancer cell lines.

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References

Details

Published: Jan 01, 2018
Vol/Issue: 9(43)
Pages: 8291-8306
License: View

Authors

E

Elise Guégain

Institut Galien Paris-Sud; CNRS UMR 8612; Univ Paris-Sud; Faculté de Pharmacie; France

J

Johanna Tran

Institut Galien Paris-Sud; CNRS UMR 8612; Univ Paris-Sud; Faculté de Pharmacie; France

Q

Quentin Deguettes

Institut Galien Paris-Sud; CNRS UMR 8612; Univ Paris-Sud; Faculté de Pharmacie; France

J

Julien Nicolas

Institut Galien Paris-Sud; CNRS UMR 8612; Univ Paris-Sud; Faculté de Pharmacie; France

Funding

Agence Nationale de la Recherche Award: ANR-11-JS08-0005

Cite This Article

Elise Guégain, Johanna Tran, Quentin Deguettes, et al. (2018). Degradable polymer prodrugs with adjustable activity from drug-initiated radical ring-opening copolymerization. Chemical Science, 9(43), 8291-8306. https://doi.org/10.1039/c8sc02256a

Degradable polymer prodrugs with adjustable activity from drug-initiated radical ring-opening copolymerization

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