Thiirane linkers directed histone H2A diubiquitination suggests plasticity in 53BP1 recognition

Jun Liang; Qingyue Gong; Yong Zheng; Ji-Shen Zheng; Changlin Tian; Jia-Bin Li

doi:10.1039/c9cc05526f

journal article Jan 01, 2019

Thiirane linkers directed histone H2A diubiquitination suggests plasticity in 53BP1 recognition

Jun Liang

Qingyue Gong Yong Zheng

Ji-Shen Zheng

Changlin Tian

Jia-Bin Li

Chemical Communications Vol. 55 No. 84 pp. 12639-12642 · Royal Society of Chemistry (RSC)

View at Publisher Save 10.1039/c9cc05526f

Abstract

Four diubiquitinated H2A analogues were newly synthesized and used to reveal the plasticity of ubiquitin chains in 53BP1 recognition.

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References

Details

Published: Jan 01, 2019
Vol/Issue: 55(84)
Pages: 12639-12642
License: View

Authors

J

Jun Liang

Hefei National Laboratory for Physical Sciences at the Microscale and School of Life Science; University of Science and Technology of China; Hefei 230026; China

Q

Qingyue Gong

Hefei National Laboratory for Physical Sciences at the Microscale and School of Life Science; University of Science and Technology of China; Hefei 230026; China; Jiangsu Key Laboratory of Neuropsychiatric Diseases and College of Pharmaceutical Sciences

Y

Yong Zheng

Hefei National Laboratory for Physical Sciences at the Microscale and School of Life Science; University of Science and Technology of China; Hefei 230026; China

J

Ji-Shen Zheng

Hefei National Laboratory for Physical Sciences at the Microscale and School of Life Science; University of Science and Technology of China; Hefei 230026; China

C

Changlin Tian

Hefei National Laboratory for Physical Sciences at the Microscale and School of Life Science; University of Science and Technology of China; Hefei 230026; China

J

Jia-Bin Li

Jiangsu Key Laboratory of Neuropsychiatric Diseases and College of Pharmaceutical Sciences; Soochow University; Suzhou; China

Funding

National Natural Science Foundation of China Award: 21708036

Fundamental Research Funds for the Central Universities Award: WK2070000115

National Postdoctoral Program for Innovative Talents Award: BH2070000085

Natural Science Foundation of Anhui Province Award: 1808085QC63

Cite This Article

Jun Liang, Qingyue Gong, Yong Zheng, et al. (2019). Thiirane linkers directed histone H2A diubiquitination suggests plasticity in 53BP1 recognition. Chemical Communications, 55(84), 12639-12642. https://doi.org/10.1039/c9cc05526f

Thiirane linkers directed histone H2A diubiquitination suggests plasticity in 53BP1 recognition

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