Intracellular label-free detection of mesenchymal stem cell metabolism within a perivascular niche-on-a-chip

Simone Perottoni; Nuno G. B. Neto; Cesare Di Nitto; Ruslan I. Dmitriev; Manuela Teresa Raimondi; Michael G. Monaghan

doi:10.1039/d0lc01034k

journal article Jan 01, 2021

Intracellular label-free detection of mesenchymal stem cell metabolism within a perivascular niche-on-a-chip

Simone Perottoni

Nuno G. B. Neto

Cesare Di Nitto Ruslan I. Dmitriev

Manuela Teresa Raimondi

Michael G. Monaghan

Lab on a Chip Vol. 21 No. 7 pp. 1395-1408 · Royal Society of Chemistry (RSC)

View at Publisher Save 10.1039/d0lc01034k

Abstract

The stem cell niche at the perivascular space plays a role in dictating the fate of stem cells within it. This study predicts
in silico
and models the perivascular space, in a miniaturised bioreactor, with non-invasive assessment of cell metabolism.

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Details

Published: Jan 01, 2021
Vol/Issue: 21(7)
Pages: 1395-1408
License: View

Authors

S

Simone Perottoni

Department of Chemistry; Materials and Chemical Engineering “Giulio Natta”; Politecnico di Milano; 32 – 20133 Milan; Italy

N

Nuno G. B. Neto

Department of Mechanical; Manufacturing and Biomedical Engineering; Trinity College Dublin; Dublin 2; Ireland

C

Cesare Di Nitto

Department of Chemistry; Materials and Chemical Engineering “Giulio Natta”; Politecnico di Milano; 32 – 20133 Milan; Italy

R

Ruslan I. Dmitriev

Tissue Engineering and Biomaterials Group; Department of Human Structure and Repair; Faculty of Medicine and Health Sciences; Ghent University; Ghent 9000

M

Manuela Teresa Raimondi

Department of Chemistry; Materials and Chemical Engineering “Giulio Natta”; Politecnico di Milano; 32 – 20133 Milan; Italy

M

Michael G. Monaghan

Department of Mechanical; Manufacturing and Biomedical Engineering; Trinity College Dublin; Dublin 2; Ireland

Funding

European Commission Award: 964481

European Research Council Award: 646990

H2020 European Research Council Award: 825159

Science Foundation Ireland Award: Infrastructure Programme: Category D 16/RI/3403

European Space Agency Award: 4000133244/20/NL/GLC

National Centre for the Replacement, Refinement and Reduction of Animals in Research Award: NC/C01903/1 – MOAB

Cite This Article

Simone Perottoni, Nuno G. B. Neto, Cesare Di Nitto, et al. (2021). Intracellular label-free detection of mesenchymal stem cell metabolism within a perivascular niche-on-a-chip. Lab on a Chip, 21(7), 1395-1408. https://doi.org/10.1039/d0lc01034k

Intracellular label-free detection of mesenchymal stem cell metabolism within a perivascular niche-on-a-chip

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