Highly-fluorescent BODIPY-functionalised metallacages as drug delivery systems: synthesis, characterisation and cellular accumulation studies

Self-assembled [Pd2L4]4+ metallacages are promising novel drug delivery systems for anticancer drugs. Their exo-functionalisation with BODIPY moieties enabled the investigation of their uptake mechanisms in cancer cells by confocal microscopy.

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References

Details

Published: Jan 01, 2022
Vol/Issue: 51(19)
Pages: 7476-7490
License: View

Authors

B

Brech Aikman

Chair of Medicinal and Bioinorganic Chemistry, Department of Chemistry, Technical University of Munich, Lichtenbergstr. 4, 85748 Garching b. München, Germany

R

Riccardo Bonsignore

Chair of Medicinal and Bioinorganic Chemistry, Department of Chemistry, Technical University of Munich, Lichtenbergstr. 4, 85748 Garching b. München, Germany; Dipartimento di Scienze e Tecnologie Biologiche, Chimiche e Farmaceutiche, Università degli Studi di Palermo, Viale delle Scienze, Edificio 17, 90128 Palermo, Italy

B

Ben Woods

Institute of Structural and Molecular Biology and Department of Biological Sciences, School of Science, Birkbeck University of London, Malet Street, London WC1E 7HX, UK

D

Daniel Doellerer

Stratingh Institute for Chemistry, University of Groningen, Nijenborgh 4, 9747 AG, Groningen, The Netherlands

R

Riccardo Scotti

Chair of Medicinal and Bioinorganic Chemistry, Department of Chemistry, Technical University of Munich, Lichtenbergstr. 4, 85748 Garching b. München, Germany

C

Claudia Schmidt

Chair of Medicinal and Bioinorganic Chemistry, Department of Chemistry, Technical University of Munich, Lichtenbergstr. 4, 85748 Garching b. München, Germany

A

Alexandra A. Heidecker

Catalysis Research Center & Department of Chemistry, Chair of Inorganic and Metal-Organic Chemistry, Technical University of Munich, Ernst-Otto-Fischer Str. 1, D-85748 Garching b. München, Germany

A

Alexander Pöthig

Catalysis Research Center & Department of Chemistry, Chair of Inorganic and Metal-Organic Chemistry, Technical University of Munich, Ernst-Otto-Fischer Str. 1, D-85748 Garching b. München, Germany

E

Edward J. Sayers

School of Pharmacy and Pharmaceutical Sciences, Cardiff University, CF10 3NB Cardiff, Wales, UK

A

Arwyn T. Jones

School of Pharmacy and Pharmaceutical Sciences, Cardiff University, CF10 3NB Cardiff, Wales, UK

A

Angela Casini

Chair of Medicinal and Bioinorganic Chemistry, Department of Chemistry, Technical University of Munich, Lichtenbergstr. 4, 85748 Garching b. München, Germany; Munich Data Science Institute, Technical University of Munich, D-85748 Garching b. München, Germany

Funding

Technische Universität München

Cite This Article

Brech Aikman, Riccardo Bonsignore, Ben Woods, et al. (2022). Highly-fluorescent BODIPY-functionalised metallacages as drug delivery systems: synthesis, characterisation and cellular accumulation studies. Dalton Transactions, 51(19), 7476-7490. https://doi.org/10.1039/d2dt00337f

Highly-fluorescent BODIPY-functionalised metallacages as drug delivery systems: synthesis, characterisation and cellular accumulation studies

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