Organ-on-a-chip with integrated semitransparent organic electrodes for barrier function monitoring

Denise Marrero; Anton Guimerà; Laure Maes; Rosa Villa; Mar Alvarez; Xavi Illa

doi:10.1039/d2lc01097f

journal article Open Access Jan 01, 2023

Organ-on-a-chip with integrated semitransparent organic electrodes for barrier function monitoring

Denise Marrero

Lab on a Chip Vol. 23 No. 7 pp. 1825-1834 · Royal Society of Chemistry (RSC)

View at Publisher Save 10.1039/d2lc01097f

Abstract

We propose an OoC with semitransparent PEDOT:PSS electrodes for barrier function monitoring where we evaluate barrier tightness, integrity, and the intercellular cleft of intestinal cells.

Topics

No keywords indexed for this article. Browse by subject →

References

46

[1]

Huh Science (2010) 10.1126/science.1188302

[2]

Bhatia Nat. Biotechnol. (2014) 10.1038/nbt.2989

[3]

Zhu Curr. Opin. Biomed. Eng. (2021) 10.1016/j.cobme.2021.100309

[4]

Marrero Biosens. Bioelectron. (2021) 10.1016/j.bios.2021.113156

[5]

Sakolish EBioMedicine (2016) 10.1016/j.ebiom.2016.02.023

[6]

Jalili-Firoozinezhad Trends Biotechnol. (2021) 10.1016/j.tibtech.2021.01.004

[7]

Jing Front. Bioeng. Biotechnol. (2020) 10.3389/fbioe.2020.00272

[8]

Shin Front. Bioeng. Biotechnol. (2019) 10.3389/fbioe.2019.00013

[9]

Jalili-Firoozinezhad Nat. Biomed. Eng. (2019) 10.1038/s41551-019-0397-0

[10]

Kim Proc. Natl. Acad. Sci. U. S. A. (2016)

[11]

Park Nat. Commun. (2019) 10.1038/s41467-019-10588-0

[12]

Paek ACS Nano (2019) 10.1021/acsnano.9b00686

[13]

Thacker eLife (2020) 10.7554/elife.59961

[14]

TEER Measurement Techniques for In Vitro Barrier Model Systems

Balaji Srinivasan, Aditya Reddy Kolli, Mandy Brigitte Esch et al.

SLAS Technology 2015 10.1177/2211068214561025

[15]

Benson Fluids Barriers CNS (2013) 10.1186/2045-8118-10-5

[16]

S.Grimnes , Bioimpedance and bioelectricity basics , Elsevier , Boston, MA , 2014

[17]

Chang Annu. Rev. Anal. Chem. (2010) 10.1146/annurev.anchem.012809.102211

[18]

Non-invasive sensing of transepithelial barrier function and tissue differentiation in organs-on-chips using impedance spectroscopy

Marinke W. van der Helm, Olivier Y. F. Henry, Amir Bein et al.

Lab on a Chip 2019 10.1039/c8lc00129d

[19]

Organs-on-chips with integrated electrodes for trans-epithelial electrical resistance (TEER) measurements of human epithelial barrier function

Olivier Y. F. Henry, Remi Villenave, Michael J. Cronce et al.

Lab on a Chip 2017 10.1039/c7lc00155j

[20]

Yeste Biotechnol. Bioeng. (2018) 10.1002/bit.26574

[21]

Arndt Biosens. Bioelectron. (2004) 10.1016/s0956-5663(03)00269-0

[22]

Kim J. Ind. Eng. Chem. (2021) 10.1016/j.jiec.2021.06.021

[23]

Shah Nat. Commun. (2016) 10.1038/ncomms11535

[24]

Trietsch Nat. Commun. (2017) 10.1038/s41467-017-00259-3

[25]

Geometric correction factor for transepithelial electrical resistance measurements in transwell and microfluidic cell cultures

J Yeste, X Illa, C Gutiérrez et al.

Journal of Physics D: Applied Physics 2016 10.1088/0022-3727/49/37/375401

[26]

Giampetruzzi Sens. Bio-Sens. Res. (2022) 10.1016/j.sbsr.2022.100512

[27]

J.Yeste , X.Illa , A.Guimerà and R.Villa , A novel strategy to monitor microfluidic in-vitro blood-brain barrier models using impedance spectroscopy , ed. S. van den Driesche , Barcelona, Spain , 2015 , p. 95180N

[28]

A.Guimerà , G.Gabriel , D.Parramon , E.Calderón and R.Villa , in World Congress on Medical Physics and Biomedical Engineering, September 7-12, 2009, Munich, Germany , ed. O. Dössel and W. C. Schlegel , Springer Berlin Heidelberg , Berlin, Heidelberg , 2009 , vol. 25/7 , pp. 868–871 10.1007/978-3-642-03885-3_241

[29]

Organs-on-Chips with combined multi-electrode array and transepithelial electrical resistance measurement capabilities

Ben M. Maoz, Anna Herland, Olivier Y. F. Henry et al.

Lab on a Chip 2017 10.1039/c7lc00412e

[30]

Renous Lab Chip (2022) 10.1039/d1lc00789k

[31]

Booth Lab Chip (2012) 10.1039/c2lc40094d

[32]

Pitsalidis Chem. Rev. (2022) 10.1021/acs.chemrev.1c00539

[33]

Moysidou Adv. Biol. (2021) 10.1002/adbi.202000306

[34]

Koutsouras Adv. Healthcare Mater. (2019) 10.1002/adhm.201901215

[35]

Waafi IEEE Sens. J. (2020) 10.1109/jsen.2019.2946854

[36]

Susloparova Sens. Actuators, B (2021) 10.1016/j.snb.2020.128895

[37]

Nunes Microfluid. Nanofluid. (2010) 10.1007/s10404-010-0605-4

[38]

Delon Biomaterials (2019) 10.1016/j.biomaterials.2019.119521

[39]

Tan PLoS One (2018) 10.1371/journal.pone.0197101

[40]

Wang Biochim. Biophys. Acta, Biomembr. (1994) 10.1016/0005-2736(94)90170-8

[41]

K. S.Cole , Membranes, ions, and impulses. A chapter of classical biophysics , University of California Press , Berkeley, 1972

[42]

Peterson J. Cell Sci. (1992) 10.1242/jcs.102.3.581

[43]

Nikulin Mol. Biol. (2018) 10.1134/s0026893318040131

[44]

A.Guimerà , E.Prats-Alfonso , R.Villa and F. J.del Campo , in Electrochemical Strategies in Detection Science , 2015 , pp. 19–84 10.1039/9781782622529-00019

[45]

Tomita J. Pharm. Sci. (1996) 10.1021/js9504604

[46]

Coyne Am. J. Respir. Cell Mol. Biol. (2000) 10.1165/ajrcmb.23.5.4164

Cited By

32

On-Chip modeling of drug-gut interactions in Oral drug delivery

Sorosh Abdollahi, Fereshteh Vajhadin · 2026

Advanced Drug Delivery Reviews

Metrics

32

Citations

46

References

Details

Published: Jan 01, 2023
Vol/Issue: 23(7)
Pages: 1825-1834
License: View

Authors

D

Denise Marrero

Instituto de Microelectrónica de Barcelona (IMB-CNM, CSIC), Campus UAB, Bellaterra, 08193, Barcelona, Spain; Centro de Investigación Biomédica en Red en Bioingeniería Biomateriales y Nanomedicina, Madrid, 50018, Spain

A

Anton Guimerà

Instituto de Microelectrónica de Barcelona (IMB-CNM, CSIC), Campus UAB, Bellaterra, 08193, Barcelona, Spain; Centro de Investigación Biomédica en Red en Bioingeniería Biomateriales y Nanomedicina, Madrid, 50018, Spain

L

Laure Maes

Department of Internal Medicine and Pediatrics, Ghent University, Gent, Belgium; Ghent Gut Inflammation Group, Ghent University, Ghent, Belgium; VIB Center for Inflammation Research, Gent, Belgium

R

Rosa Villa

Instituto de Microelectrónica de Barcelona (IMB-CNM, CSIC), Campus UAB, Bellaterra, 08193, Barcelona, Spain; Centro de Investigación Biomédica en Red en Bioingeniería Biomateriales y Nanomedicina, Madrid, 50018, Spain

M

Mar Alvarez

Instituto de Microelectrónica de Barcelona (IMB-CNM, CSIC), Campus UAB, Bellaterra, 08193, Barcelona, Spain

X

Xavi Illa

Instituto de Microelectrónica de Barcelona (IMB-CNM, CSIC), Campus UAB, Bellaterra, 08193, Barcelona, Spain; Centro de Investigación Biomédica en Red en Bioingeniería Biomateriales y Nanomedicina, Madrid, 50018, Spain

Cite This Article

Denise Marrero, Anton Guimerà, Laure Maes, et al. (2023). Organ-on-a-chip with integrated semitransparent organic electrodes for barrier function monitoring. Lab on a Chip, 23(7), 1825-1834. https://doi.org/10.1039/d2lc01097f

Organ-on-a-chip with integrated semitransparent organic electrodes for barrier function monitoring

You May Also Like