Isothiocyanates (in situ) and sulfonyl chlorides in water for N-functionalization of bicyclic amidines: access to N-alkylated γ-/ω-lactam derivatized thiourea and sulfonamides

Pankaj Kumar; Aman Bhalla

doi:10.1039/d3ob01584j

journal article Jan 01, 2023

Isothiocyanates (in situ) and sulfonyl chlorides in water for N-functionalization of bicyclic amidines: access to N-alkylated γ-/ω-lactam derivatized thiourea and sulfonamides

Pankaj Kumar

Aman Bhalla

Organic & Biomolecular Chemistry Vol. 21 No. 44 pp. 8868-8874 · Royal Society of Chemistry (RSC)

View at Publisher Save 10.1039/d3ob01584j

Abstract

Electrophilic reaction of β-isothiocyanato sulfides and sulfonyl chloride in water with bicyclic amidines affording γ-/ω-lactam-derived β-thio(uredo) sulfides/sulfonamides.

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Metrics

7

Citations

52

References

Details

Published: Jan 01, 2023
Vol/Issue: 21(44)
Pages: 8868-8874
License: View

Authors

P

Pankaj Kumar

Department of Chemistry and Centre of Advance Studies in Chemistry, Panjab University, Chandigarh, 160014, UT, India

A

Aman Bhalla

Department of Chemistry and Centre of Advance Studies in Chemistry, Panjab University, Chandigarh, 160014, UT, India

Funding

University Grants Commission

Council of Scientific and Industrial Research, India Award: 09/135/(0823)2018-EMR-I

Panjab University

Cite This Article

Pankaj Kumar, Aman Bhalla (2023). Isothiocyanates (in situ) and sulfonyl chlorides in water for N-functionalization of bicyclic amidines: access to N-alkylated γ-/ω-lactam derivatized thiourea and sulfonamides. Organic & Biomolecular Chemistry, 21(44), 8868-8874. https://doi.org/10.1039/d3ob01584j

Isothiocyanates (in situ) and sulfonyl chlorides in water for N-functionalization of bicyclic amidines: access to N-alkylated γ-/ω-lactam derivatized thiourea and sulfonamides

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