Extracellular vesicles: from intracellular trafficking molecules to fully fortified delivery vehicles for cancer therapeutics

Adham H. Mohamed; Tasneem Abaza; Yomna A. Youssef; Mona Rady; Sherif Ashraf Fahmy; Rabab Kamel; Nabila Hamdi; Eleni Efthimiado; Maria Braoudaki; Rana A. Youness

doi:10.1039/d4na00393d

journal article Open Access Jan 01, 2025

Extracellular vesicles: from intracellular trafficking molecules to fully fortified delivery vehicles for cancer therapeutics

Adham H. Mohamed

Tasneem Abaza

Yomna A. Youssef Mona Rady Sherif Ashraf Fahmy

Rabab Kamel

Nabila Hamdi Eleni Efthimiado

Maria Braoudaki Rana A. Youness

Nanoscale Advances Vol. 7 No. 4 pp. 934-962 · Royal Society of Chemistry (RSC)

View at Publisher Save 10.1039/d4na00393d

Abstract

Extracellular vesicles (EVs) are emerging tools in cancer diagnosis, prognosis and therapeutics.

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References

272

[1]

Doyle Cells (2019) 10.3390/cells8070727

[2]

Jaiswal Front. Oncol. (2019) 10.3389/fonc.2019.00125

[3]

Deatherage Infect. Immun. (2012) 10.1128/iai.06014-11

[4]

Shedding light on the cell biology of extracellular vesicles

Guillaume van Niel, Gisela D'Angelo, Graça Raposo

Nature Reviews Molecular Cell Biology 2018 10.1038/nrm.2017.125

[5]

Wang Biomed. Pharmacother. (2022) 10.1016/j.biopha.2022.113480

[6]

Zaborowski Bioscience (2015) 10.1093/biosci/biv084

[7]

Youness Polymers (2023) 10.3390/polym15061464

[8]

Ramzy Biomed. Mater. (2022) 10.1088/1748-605x/aca85d

[9]

Youness ACS Omega (2023) 10.1021/acsomega.3c04134

[10]

Sedky Nanoscale Adv. (2023) 10.1039/d3na00368j

[11]

Jeppesen Cell (2019) 10.1016/j.cell.2019.02.029

[12]

V. R.Minciacchi , M. R.Freeman , and D.Di Vizio , Extracellular vesicles in cancer: exosomes, microvesicles and the emerging role of large oncosomes , in Seminars in Cell & Developmental Biology , Elsevier , 2015

[13]

Borges Braz. J. Med. Biol. Res. (2013) 10.1590/1414-431x20132964

[14]

Huyan Int. J. Nanomed. (2020) 10.2147/ijn.s238099

[15]

ZeinElAbdeen J. Mammary Gland Biol. Neoplasia (2022) 10.1007/s10911-022-09511-z

[16]

Youness Growth Factors (2016) 10.1080/08977194.2016.1200571

[17]

Shaalan Nat. Prod. Res. (2018) 10.1080/14786419.2017.1366478

[18]

Selem Pathol., Res. Pract. (2023) 10.1016/j.prp.2023.154579

[19]

Abdallah Anti Cancer Agents Med. Chem. (2022) 10.2174/1871520621666210419093652

[20]

Youness Nitric Oxide (2018) 10.1016/j.niox.2018.07.004

[21]

Selem Non-coding RNA Res. (2021) 10.1016/j.ncrna.2021.11.001

[22]

Mekky Transl. Oncol. (2023) 10.1016/j.tranon.2023.101653

[23]

Dawoud Non-coding RNA Res. (2023) 10.1016/j.ncrna.2022.09.011

[24]

Fahmy Cancers (2022) 10.3390/cancers14215244

[25]

Abaza Int. J. Mol. Sci. (2023) 10.3390/ijms242216484

[26]

S. E.Wang , Extracellular vesicles in cancer therapy , in Seminars in Cancer Biology , Elsevier , 2022

[27]

Elemam Breast Cancer Front. Oncol. (2022) 10.3389/fonc.2022.847543

[28]

Elemam Front. Med. (2023) 10.3389/fmed.2023.1202581

[29]

Becker Cancer cell (2016) 10.1016/j.ccell.2016.10.009

[30]

Chin Clin. Cancer Res. (2016) 10.1158/1078-0432.ccr-16-0028

[31]

Wang Cold Spring Harb. Perspect. Med. (2020) 10.1101/cshperspect.a037275

[32]

Zhang Nat. Cell Biol. (2015) 10.1038/ncb3181

[33]

Rizk Life Sci. (2024) 10.1016/j.lfs.2024.122850

[34]

Abd El Fattah Int. J. Biol. Macromol. (2023) 10.1016/j.ijbiomac.2023.126739

[35]

Shtam Cell Commun. Signal. (2013) 10.1186/1478-811x-11-88

[36]

Bakhti J. Biol. Chem. (2011) 10.1074/jbc.m110.190009

[37]

Wang J. Neurosci. (2011) 10.1523/jneurosci.6476-10.2011

[38]

Abels Cell. Mol. Neurobiol. (2016) 10.1007/s10571-016-0366-z

[39]

Mulcahy J. Extracell. Vesicles (2014) 10.3402/jev.v3.24641

[40]

Haraszti J. Extracell. Vesicles (2016) 10.3402/jev.v5.32570

[41]

Suire Bioengineering (2022) 10.3390/bioengineering9030105

[42]

Raposo J. Cell Biol. (2013) 10.1083/jcb.201211138

[43]

Bebelman Pharmacol. Therapeut. (2018) 10.1016/j.pharmthera.2018.02.013

[44]

Möbius J. Histochem. Cytochem. (2002) 10.1177/002215540205000105

[45]

Tauro Methods (2012) 10.1016/j.ymeth.2012.01.002

[46]

Witwer J. Extracell. Vesicles (2013) 10.3402/jev.v2i0.20360

[47]

Akers J. Neuro Oncol. (2013) 10.1007/s11060-013-1084-8

[48]

Théry J. Extracell. Vesicles (2018) 10.1080/20013078.2018.1535750

[49]

Cai Dev. Cell (2007) 10.1016/j.devcel.2007.04.005

[50]

Tricarico Small GTPases (2017) 10.1080/21541248.2016.1215283

Showing 50 of 272 references

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Details

Published: Jan 01, 2025
Vol/Issue: 7(4)
Pages: 934-962
License: View

Authors

A

Adham H. Mohamed

Department of Chemistry, Faculty of Science, Cairo University, 12613, Giza, Egypt

T

Tasneem Abaza

Biotechnology and Biomolecular Chemistry Program, Faculty of Science, Cairo University, 12613, Giza, Egypt; Université Paris-Saclay, Université d'Evry Val D'Essonne, 91000 Évry-Courcouronnes, Île-de-France, France

Y

Yomna A. Youssef

Department of Physiology, Faculty of Physical Therapy, German International University (GIU), 11835, Cairo, Egypt; Molecular Biology and Biochemistry Department, Faculty of Biotechnology, German International University (GIU), 11835, Cairo, Egypt

M

Mona Rady

Microbiology, Immunology and Biotechnology Department, Faculty of Pharmacy and Biotechnology, German University in Cairo (GUC), 11835, Cairo, Egypt; Faculty of Biotechnology, German International University, New Administrative Capital, 11835, Cairo, Egypt

S

Sherif Ashraf Fahmy

Department of Pharmaceutics and Biopharmaceutics, University of Marburg, Robert-Koch-Str. 4, 35037 Marburg, Germany

R

Rabab Kamel

Pharmaceutical Technology Department, National Research Centre, 12622, Cairo, Egypt

N

Nabila Hamdi

Pharmacology and Toxicology Department, Faculty of Pharmacy and Biotechnology, German University in Cairo (GUC), 11835, Cairo, Egypt

E

Eleni Efthimiado

Inorganic Chemistry Laboratory, Chemistry Department, National and Kapodistrian University of Athens, Athens, Greece

M

Maria Braoudaki

Department of Clinical, Pharmaceutical, and Biological Science, School of Life and Medical Sciences, University of Hertfordshire, Hatfield AL10 9AB, UK

R

Rana A. Youness

Molecular Biology and Biochemistry Department, Faculty of Biotechnology, German International University (GIU), 11835, Cairo, Egypt

Funding

Alexander von Humboldt-Stiftung

Cite This Article

Adham H. Mohamed, Tasneem Abaza, Yomna A. Youssef, et al. (2025). Extracellular vesicles: from intracellular trafficking molecules to fully fortified delivery vehicles for cancer therapeutics. Nanoscale Advances, 7(4), 934-962. https://doi.org/10.1039/d4na00393d

Extracellular vesicles: from intracellular trafficking molecules to fully fortified delivery vehicles for cancer therapeutics

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