Design and synthesis of nucleic acid nano-environment interactome-targeting small molecule PROTACs and their anticancer activity

Sadiya Tanga; Arkadeep Karmakar; Arpita Hota; Paramita Banerjee; Basudeb Maji

doi:10.1039/d4nr01006j

journal article Jan 01, 2024

Design and synthesis of nucleic acid nano-environment interactome-targeting small molecule PROTACs and their anticancer activity

Sadiya Tanga

Arkadeep Karmakar

Arpita Hota

Paramita Banerjee Basudeb Maji

Nanoscale Vol. 16 No. 26 pp. 12502-12509 · Royal Society of Chemistry (RSC)

View at Publisher Save 10.1039/d4nr01006j

Abstract

Small molecule-based nucleic-acid interactome protein degradation through PROteolysis TArgeting Chimeras (PROTACs) is a relatively new modality in cellular interventions.

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Metrics

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Citations

36

References

Details

Published: Jan 01, 2024
Vol/Issue: 16(26)
Pages: 12502-12509
License: View

Authors

S

Sadiya Tanga

Ashoka University, Department of Chemistry, Rajiv Gandhi Education City, Sonipat, Haryana 131029, India; Bose Institute, Department of Biological Sciences, EN 80, Sector V, Bidhannagar, Kolkata 700091, West Bengal, India

A

Arkadeep Karmakar

Bose Institute, Department of Biological Sciences, EN 80, Sector V, Bidhannagar, Kolkata 700091, West Bengal, India

A

Arpita Hota

Bose Institute, Department of Biological Sciences, EN 80, Sector V, Bidhannagar, Kolkata 700091, West Bengal, India

P

Paramita Banerjee

S N Bose National Centre for Basic Science, JD Block, Sector 3, Bidhannagar, Kolkata 700106, West Bengal, India

B

Basudeb Maji

Bose Institute, Department of Biological Sciences, EN 80, Sector V, Bidhannagar, Kolkata 700091, West Bengal, India

Funding

University Grants Commission

Council of Scientific and Industrial Research, India

Cite This Article

Sadiya Tanga, Arkadeep Karmakar, Arpita Hota, et al. (2024). Design and synthesis of nucleic acid nano-environment interactome-targeting small molecule PROTACs and their anticancer activity. Nanoscale, 16(26), 12502-12509. https://doi.org/10.1039/d4nr01006j

Design and synthesis of nucleic acid nano-environment interactome-targeting small molecule PROTACs and their anticancer activity

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