Atomic force microscopy combined with microfluidics for label-free sorting and automated nanomechanics of circulating tumor cells in liquid biopsy

Xiaoqun Qi; Sen Lin; Mi Li

doi:10.1039/d4nr04033c

journal article Jan 01, 2025

Atomic force microscopy combined with microfluidics for label-free sorting and automated nanomechanics of circulating tumor cells in liquid biopsy

Xiaoqun Qi Sen Lin

Mi Li

Nanoscale Vol. 17 No. 8 pp. 4695-4712 · Royal Society of Chemistry (RSC)

View at Publisher Save 10.1039/d4nr04033c

Abstract

This work combines deep learning image recognition-assisted atomic force microscopy with contraction–expansion microfluidics to achieve label-free sorting and automated nanomechanics of circulating tumor cells for cancer liquid biopsy.

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Citations

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References

Details

Published: Jan 01, 2025
Vol/Issue: 17(8)
Pages: 4695-4712
License: View

Authors

X

Xiaoqun Qi

School of Automation and Electrical Engineering, Shenyang Ligong University, Shenyang 110159, China; State Key Laboratory of Robotics, Shenyang Institute of Automation, Chinese Academy of Sciences, Shenyang 110016, China

S

Sen Lin

School of Automation and Electrical Engineering, Shenyang Ligong University, Shenyang 110159, China

M

Mi Li

State Key Laboratory of Robotics, Shenyang Institute of Automation, Chinese Academy of Sciences, Shenyang 110016, China

Funding

National Natural Science Foundation of China Award: 62273330

Natural Science Foundation of Liaoning Province Award: 2024JH3/50100021

Cite This Article

Xiaoqun Qi, Sen Lin, Mi Li (2025). Atomic force microscopy combined with microfluidics for label-free sorting and automated nanomechanics of circulating tumor cells in liquid biopsy. Nanoscale, 17(8), 4695-4712. https://doi.org/10.1039/d4nr04033c

Atomic force microscopy combined with microfluidics for label-free sorting and automated nanomechanics of circulating tumor cells in liquid biopsy

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