Benzimidazole chemistry in oncology: recent developments in synthesis, activity, and SAR analysis

Basant Farag; Magdi E. A. Zaki; Doaa A. Elsayed; Sobhi M. Gomha

doi:10.1039/d5ra01077b

journal article Open Access Jan 01, 2025

Benzimidazole chemistry in oncology: recent developments in synthesis, activity, and SAR analysis

Basant Farag

Magdi E. A. Zaki

Doaa A. Elsayed

Sobhi M. Gomha

RSC Advances Vol. 15 No. 23 pp. 18593-18647 · Royal Society of Chemistry (RSC)

View at Publisher Save 10.1039/d5ra01077b

Abstract

Benzimidazole is crucial in drug design, with derivatives showing anticancer activity
via
DNA interaction and enzyme inhibition; SAR studies aim to improve efficacy, selectivity, and reduce toxicity.

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Details

Published: Jan 01, 2025
Vol/Issue: 15(23)
Pages: 18593-18647
License: View

Authors

B

Basant Farag

Department of Chemistry, Faculty of Science, Zagazig University, Zagazig, 44519, Egypt

M

Magdi E. A. Zaki

Department of Chemistry, Faculty of Science, Imam Mohammad Ibn Saud Islamic University (IMSIU), Riyadh 11623, Saudi Arabia

D

Doaa A. Elsayed

Department of Chemistry, Faculty of Science, Zagazig University, Zagazig, 44519, Egypt

S

Sobhi M. Gomha

Department of Chemistry, Faculty of Science, Islamic University of Madinah, Madinah, 42351, Saudi Arabia

Funding

Deanship of Scientific Research, Imam Mohammed Ibn Saud Islamic University Award: IMSIU-DDRSP2501

Cite This Article

Basant Farag, Magdi E. A. Zaki, Doaa A. Elsayed, et al. (2025). Benzimidazole chemistry in oncology: recent developments in synthesis, activity, and SAR analysis. RSC Advances, 15(23), 18593-18647. https://doi.org/10.1039/d5ra01077b

Benzimidazole chemistry in oncology: recent developments in synthesis, activity, and SAR analysis

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