A dual-targeting photosensitizer for simultaneous mitochondrial and lysosomal disruption in cancer and antibacterial photodynamic therapy

Chaewoon Cho; K. M. K. Swamy; Bingqing Sun; Gyoungmi Kim; Lei Liu; Won Jun Jang; Juyoung Yoon

doi:10.1039/d5tb01345c

journal article Open Access Jan 01, 2025

A dual-targeting photosensitizer for simultaneous mitochondrial and lysosomal disruption in cancer and antibacterial photodynamic therapy

Chaewoon Cho K. M. K. Swamy Bingqing Sun Gyoungmi Kim Lei Liu

Won Jun Jang

Juyoung Yoon

Journal of Materials Chemistry B Vol. 13 No. 34 pp. 10576-10583 · Royal Society of Chemistry (RSC)

View at Publisher Save 10.1039/d5tb01345c

Abstract

MCQ-1 is a dual-functional type I photosensitizer, capable of targeting both mitochondria and lysosomes in cancer cells, while also exhibiting selective antibacterial activity against Gram-positive bacteria, including MRSA.

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References

Details

Published: Jan 01, 2025
Vol/Issue: 13(34)
Pages: 10576-10583
License: View

Authors

C

Chaewoon Cho

Department of Chemistry and Nanoscience, Ewha Womans University, Seoul 03760, Korea; Graduate Program in Innovative Biomaterials Convergence, Ewha Womans University, Seoul 03760, Korea

K

K. M. K. Swamy

Department of Chemistry and Nanoscience, Ewha Womans University, Seoul 03760, Korea

B

Bingqing Sun

College of Resource and Environment, Anhui Science and Technology University, Fengyang 233100, China

G

Gyoungmi Kim

Department of Chemistry and Nanoscience, Ewha Womans University, Seoul 03760, Korea

L

Lei Liu

College of Resource and Environment, Anhui Science and Technology University, Fengyang 233100, China

W

Won Jun Jang

Department of Chemistry and Nanoscience, Ewha Womans University, Seoul 03760, Korea

J

Juyoung Yoon

Department of Chemistry and Nanoscience, Ewha Womans University, Seoul 03760, Korea; Graduate Program in Innovative Biomaterials Convergence, Ewha Womans University, Seoul 03760, Korea

Funding

National Research Foundation of Korea Award: RS-2023-00304224

Anhui University of Science and Technology Award: 2021zrzd15

Cite This Article

Chaewoon Cho, K. M. K. Swamy, Bingqing Sun, et al. (2025). A dual-targeting photosensitizer for simultaneous mitochondrial and lysosomal disruption in cancer and antibacterial photodynamic therapy. Journal of Materials Chemistry B, 13(34), 10576-10583. https://doi.org/10.1039/d5tb01345c

A dual-targeting photosensitizer for simultaneous mitochondrial and lysosomal disruption in cancer and antibacterial photodynamic therapy

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