Chronic PFOA and PFOS exposure triggers cellular oxidative stress and alters lipid levels as revealed through multi-omics analysis

Jenise Z. Paddayuman; Judith R. Cristobal; Luane J. B. Landau; Ashleigh L. Gagnon; Omer Gokcumen; Diana S. Aga; G. Ekin Atilla-Gokcumen

doi:10.1039/d5va00353a

journal article Open Access Jan 01, 2026

Chronic PFOA and PFOS exposure triggers cellular oxidative stress and alters lipid levels as revealed through multi-omics analysis

Jenise Z. Paddayuman

Judith R. Cristobal

Luane J. B. Landau Ashleigh L. Gagnon Omer Gokcumen

Diana S. Aga

G. Ekin Atilla-Gokcumen

Environmental Science: Advances Vol. 5 No. 4 pp. 1081-1094 · Royal Society of Chemistry (RSC)

View at Publisher Save 10.1039/d5va00353a

Abstract

Prolonged, low-dose exposure to PFOA and PFOS results in cumulative disruptions in lipid metabolism and induces sustained cellular stress responses in human epithelial cells.

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Details

Published: Jan 01, 2026
Vol/Issue: 5(4)
Pages: 1081-1094
License: View

Authors

J

Jenise Z. Paddayuman

Department of Chemistry, University at Buffalo, The State University of New York (SUNY), Buffalo, New York 14260, USA

J

Judith R. Cristobal

Department of Chemistry, University at Buffalo, The State University of New York (SUNY), Buffalo, New York 14260, USA; Research and Education in eNergy, Environment and Water (RENEW) Institute, University at Buffalo, The State University of New York (SUNY), Buffalo, New York 14260, USA

L

Luane J. B. Landau

Department of Biological Sciences, University at Buffalo, The State University of New York (SUNY), Buffalo, New York 14260, USA

A

Ashleigh L. Gagnon

Department of Chemistry, University at Buffalo, The State University of New York (SUNY), Buffalo, New York 14260, USA

O

Omer Gokcumen

Department of Biological Sciences, University at Buffalo, The State University of New York (SUNY), Buffalo, New York 14260, USA

D

Diana S. Aga

Department of Chemistry, University at Buffalo, The State University of New York (SUNY), Buffalo, New York 14260, USA; Research and Education in eNergy, Environment and Water (RENEW) Institute, University at Buffalo, The State University of New York (SUNY), Buffalo, New York 14260, USA

G

G. Ekin Atilla-Gokcumen

Department of Chemistry, University at Buffalo, The State University of New York (SUNY), Buffalo, New York 14260, USA

Funding

Research Foundation for the State University of New York Award: 241056

Cite This Article

Jenise Z. Paddayuman, Judith R. Cristobal, Luane J. B. Landau, et al. (2026). Chronic PFOA and PFOS exposure triggers cellular oxidative stress and alters lipid levels as revealed through multi-omics analysis. Environmental Science: Advances, 5(4), 1081-1094. https://doi.org/10.1039/d5va00353a

Chronic PFOA and PFOS exposure triggers cellular oxidative stress and alters lipid levels as revealed through multi-omics analysis

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