Apoptosis and apoptotic body: disease message and therapeutic target potentials

Xuebo Xu; Yueyang Lai; Zi-Chun Hua

doi:10.1042/bsr20180992

journal article Open Access Jan 01, 2019

Apoptosis and apoptotic body: disease message and therapeutic target potentials

Xuebo Xu Yueyang Lai Zi-Chun Hua

Bioscience Reports Vol. 39 No. 1 · Portland Press Ltd.

View at Publisher Save 10.1042/bsr20180992

Abstract

Abstract
Apoptosis is widely known as programmed cell death eliciting no inflammatory responses. The intricacy of apoptosis has been a focus of an array of researches, accumulating a wealth of knowledge which led to not only a better understanding of the fundamental process, but also potent therapies of diseases. The classic intrinsic and extrinsic signaling pathways of apoptosis, along with regulatory factors have been well delineated. Drugs and therapeutic measures designed based on current understanding of apoptosis have long been employed. Small-molecule apoptosis inducers have been clinically used for eliminating morbid cells and therefore treating diseases, such as cancer. Biologics with improved apoptotic efficacy and selectivity, such as recombinant proteins and antibodies, are being extensively researched and some have been approved by the FDA. Apoptosis also produces membrane-bound vesicles derived from disassembly of apoptotic cells, now known as apoptotic bodies (ApoBDs). These little sealed sacs containing information as well as substances from dying cells were previously regarded as garbage bags until they were discovered to be capable of delivering useful materials to healthy recipient cells (e.g., autoantigens). In this review, current understandings and knowledge of apoptosis were summarized and discussed with a focus on apoptosis-related therapeutic applications and ApoBDs.

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Details

Published: Jan 01, 2019
Vol/Issue: 39(1)
License: View

Authors

X

Xuebo Xu

State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing 210023, China

Y

Yueyang Lai

State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing 210023, China

Z

Zi-Chun Hua

State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing 210023, China; Changzhou High-Tech Research Institute of Nanjing University and Jiangsu TargetPharma Laboratories Inc., Changzhou 213164, China; Shenzhen Research Institute of Nanjing University, Shenzhen 518057, China

Cite This Article

Xuebo Xu, Yueyang Lai, Zi-Chun Hua (2019). Apoptosis and apoptotic body: disease message and therapeutic target potentials. Bioscience Reports, 39(1). https://doi.org/10.1042/bsr20180992

Apoptosis and apoptotic body: disease message and therapeutic target potentials

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