Biogenesis and activity regulation of protein phosphatase 1

Iris Verbinnen; Mónica Ferreira; Mathieu Bollen

doi:10.1042/bst20160154

journal article Feb 08, 2017

Biogenesis and activity regulation of protein phosphatase 1

Iris Verbinnen Mónica Ferreira Mathieu Bollen

Biochemical Society Transactions Vol. 45 No. 1 pp. 89-99 · Portland Press Ltd.

View at Publisher Save 10.1042/bst20160154

Abstract

Protein phosphatase 1 (PP1) is expressed in all eukaryotic cells and catalyzes a substantial fraction of phosphoserine/threonine dephosphorylation reactions. It forms stable complexes with PP1-interacting proteins (PIPs) that guide the phosphatase throughout its life cycle and control its fate and function. The diversity of PIPs is huge (≈200 in vertebrates), and most of them combine short linear motifs to form large and unique interaction interfaces with PP1. Many PIPs have separate domains for PP1 anchoring, PP1 regulation, substrate recruitment and subcellular targeting, which enable them to direct associated PP1 to a specific subset of substrates and mediate acute activity control. Hence, PP1 functions as the catalytic subunit of a large number of multimeric holoenzymes, each with its own subset of substrates and mechanism(s) of regulation.

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Details

Published: Feb 08, 2017
Vol/Issue: 45(1)
Pages: 89-99

Authors

I

Iris Verbinnen

Laboratory of Biosignaling & Therapeutics, KU Leuven Department of Cellular and Molecular Medicine, University of Leuven, B-3000 Leuven, Belgium

M

Mónica Ferreira

Laboratory of Biosignaling & Therapeutics, KU Leuven Department of Cellular and Molecular Medicine, University of Leuven, B-3000 Leuven, Belgium

M

Mathieu Bollen

Laboratory of Biosignaling & Therapeutics, KU Leuven Department of Cellular and Molecular Medicine, University of Leuven, B-3000 Leuven, Belgium

Cite This Article

Iris Verbinnen, Mónica Ferreira, Mathieu Bollen (2017). Biogenesis and activity regulation of protein phosphatase 1. Biochemical Society Transactions, 45(1), 89-99. https://doi.org/10.1042/bst20160154

Biogenesis and activity regulation of protein phosphatase 1

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