Muscle function during repetitive moderate-intensity muscle contractions in myoadenylate deaminase-deficient Dutch subjects

C.J. DE RUITER; A.M. MAY; B.G.M. VAN ENGELEN; R.A. WEVERS; G.C. STEENBERGEN-SPANJERS; A. DE HAAN

doi:10.1042/cs1020531

journal article Apr 18, 2002

Muscle function during repetitive moderate-intensity muscle contractions in myoadenylate deaminase-deficient Dutch subjects

C.J. DE RUITER A.M. MAY B.G.M. VAN ENGELEN R.A. WEVERS G.C. STEENBERGEN-SPANJERS A. DE HAAN

Clinical Science Vol. 102 No. 5 pp. 531-539 · Portland Press Ltd.

View at Publisher Save 10.1042/cs1020531

Abstract

We investigated whether the capacity for repetitive submaximal muscle contraction was reduced in a group of subjects (n = 8) with a primary deficiency of myoadenylate deaminase (MAD). Quadriceps femoris muscle fatigue was evaluated using voluntary and electrically stimulated contractions during 20min of repetitive voluntary isometric contractions at 40% of maximal force-generating capacity (MFGC). After 5min of exercise, MFGC had declined significantly to 70.6±4.1% (mean±S.E.M.) and 87.2±1.6% of baseline values in MAD-deficient and sedentary control subjects (n = 8) respectively (P = 0.002 between groups). After 5min of exercise, the half-relaxation time had increased significantly to 113.4±6.1% of basline in MAD-deficient muscle, but had decreased significantly to 94.1±1.3% in control subjects (P = 0.003 between groups). All control subjects completed the 20-min exercise test. Five of the MAD-deficient subjects had to stop exercising due to early muscle fatigue; however, three of the MAD-deficient subjects were able to complete the 20-min exercise test. In conclusion, although the capacity for repetitive submaximal isometric muscle contractions for the group of MAD-deficient subjects was significantly decreased, it remains uncertain whether MAD deficiency is the sole cause of pronounced muscle fatigue.

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Published: Apr 18, 2002
Vol/Issue: 102(5)
Pages: 531-539

Authors

C

C.J. DE RUITER

Institute for Fundamental and Clinical Human Movement Sciences, Vrije Universiteit, Van der Boechorststraat 9, 1081 BT Amsterdam, The Netherlands

A

A.M. MAY

Institute for Fundamental and Clinical Human Movement Sciences, Vrije Universiteit, Van der Boechorststraat 9, 1081 BT Amsterdam, The Netherlands

B

B.G.M. VAN ENGELEN

Institute for Fundamental and Clinical Human Movement Sciences, Department of Neurology, University Medical Centre Nijmegen, 6500 HB Nijmegen, The Netherlands

R

R.A. WEVERS

Institute for Fundamental and Clinical Human Movement Sciences, Department of Neurology, University Medical Centre Nijmegen, 6500 HB Nijmegen, The Netherlands

G

G.C. STEENBERGEN-SPANJERS

Institute for Fundamental and Clinical Human Movement Sciences, Department of Neurology, University Medical Centre Nijmegen, 6500 HB Nijmegen, The Netherlands

A

A. DE HAAN

Institute for Fundamental and Clinical Human Movement Sciences, Vrije Universiteit, Van der Boechorststraat 9, 1081 BT Amsterdam, The Netherlands

Cite This Article

C.J. DE RUITER, A.M. MAY, B.G.M. VAN ENGELEN, et al. (2002). Muscle function during repetitive moderate-intensity muscle contractions in myoadenylate deaminase-deficient Dutch subjects. Clinical Science, 102(5), 531-539. https://doi.org/10.1042/cs1020531

Muscle function during repetitive moderate-intensity muscle contractions in myoadenylate deaminase-deficient Dutch subjects

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