Macrocyclic Ligand Design. Structure—Function Relationships Underlying the Interaction of Substituted Derivatives of Oxygen-Nitrogen Macrocycles with Selected Transition and Post Transition Metal Ions

Ian M. Atkinson; Karl A. Byriel; Peter S. K. Chia; Colin H. L. Kennard; Anthony J. Leong; Leonard F. Lindoy; Mark P. Lowe; Sumathi Mahendran; Graham Smith; Gang Wei

doi:10.1071/c98076

journal article Nov 17, 1998

Macrocyclic Ligand Design. Structure—Function Relationships Underlying the Interaction of Substituted Derivatives of Oxygen-Nitrogen Macrocycles with Selected Transition and Post Transition Metal Ions

Ian M. Atkinson Karl A. Byriel Peter S. K. Chia Colin H. L. Kennard Anthony J. Leong Leonard F. Lindoy

Mark P. Lowe Sumathi Mahendran Graham Smith

Gang Wei

Australian Journal of Chemistry Vol. 51 No. 11 pp. 985-992 · CSIRO Publishing

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Abstract

The effect of methyl substitution on 15- and 17-membered macrocycles (incorporating N2O2- and N3O2-donors, respectively) on their interaction with cobalt(II), nickel(II), copper(II), zinc(II), cadmium(II) and lead(II) has been investigated. The results are compared with those obtained for the corresponding complexes of the unsubstituted (parent) rings. Binding constants for the formation of the metal complexes have been determined potentiometrically in 95% methanol ( I = 0·1; Et4NClO4). An X-ray crystallographic study of [NiL(H2O)] (ClO4)2 (where L is the dimethyl derivative of a 17-membered, N3O2-donor macrocycle) confirms that the nickel ion is six-coordinate, with the complex cation exhibiting a distorted octahedral geometry defined by all five donor atoms of the O2N3-macrocycle (in its meso form) and the oxygen of the water molecule. In this structure the macrocyclic backbone incorporating the N3-donor fragment is arranged facially. Molecular mechanics modelling of this complex predicts that the observed facial configuration will be favoured over an alternative facial arrangement or a meridional one.

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Published: Nov 17, 1998
Vol/Issue: 51(11)
Pages: 985-992
License: View

Authors

From the University of Nebraska Medical Center, Omaha (S.S.); Centro Universitario de Ciencias de la Salud, University of Guadalajara, Guadalajara, Mexico (J.-F.A.-V.); Broward Health Medical Center, Broward Health Imperial Point, Fort Lauderdale, FL (G.J.R.); Fatebenefratelli Sacco Hospital, Milan (G.R.); the Center for Infectious Diseases, Berlin (A.B.); Hospital de Elche, Elche, Spain (M.M.); Maxwell Centre, Durban, South Africa (G.L.); the Central Research Institute of Epidemiology, Moscow (V.P....

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Gang Wei

Cite This Article

Ian M. Atkinson, Karl A. Byriel, Peter S. K. Chia, et al. (1998). Macrocyclic Ligand Design. Structure—Function Relationships Underlying the Interaction of Substituted Derivatives of Oxygen-Nitrogen Macrocycles with Selected Transition and Post Transition Metal Ions. Australian Journal of Chemistry, 51(11), 985-992. https://doi.org/10.1071/c98076

Macrocyclic Ligand Design. Structure—Function Relationships Underlying the Interaction of Substituted Derivatives of Oxygen-Nitrogen Macrocycles with Selected Transition and Post Transition Metal Ions

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