Biological Markers Associated with Prolonged Survival in African Children Maternally Infected by the Human Immunodeficiency Virus Type 1

Philippe Van de Perre; Philippe Lepage; Arlette Simonon; Claude Desgranges; Deo-Gratias Hitimana; Anatholie Bazubagira; Christiaan van Goethem; Andrea Kleinschmidt; Françoise Bex; Kristina Broliden; Volker Erfle; Frances Gotch; Arsène Burny

doi:10.1089/aid.1992.8.435

journal article Apr 01, 1992

Biological Markers Associated with Prolonged Survival in African Children Maternally Infected by the Human Immunodeficiency Virus Type 1

Arlette Simonon Claude Desgranges Deo-Gratias Hitimana Anatholie Bazubagira Christiaan van Goethem Andrea Kleinschmidt Françoise Bex Kristina Broliden Volker Erfle Frances Gotch Arsène Burny

AIDS Research and Human Retroviruses Vol. 8 No. 4 pp. 435-442 · SAGE Publications

View at Publisher Save 10.1089/aid.1992.8.435

Abstract

Sixteen children over the age of 5 years (Group 1) have been identified out of 537 children infected by human immunodeficiency virus and born to HIV-infected mothers, in Kigali, Rwanda. They were followed up for 2 years and compared with 16 younger AIDS patients (Group 2) and with 16 age- and gender-matched HIV-1 seronegative children (Group 3). Fourteen Group 1 subjects had anti-HIV-1 IgM which persisted during the entire study period, in 11 cases directed to HIV-1 envelope proteins. In vitro, immortalization of B lymphocytes by the Epstein-Barr virus confirmed a high production of IgM to envelope proteins. All these patients had anti-p 17 IgG which was not observed in 7 patients from Group 2. All 16 children mounted significant titers of neutralizing antibodies to HTLV
IIIB
, and, in 8 patients tested, against two other HIV-1 strains, RII and MN. HIV-1-specific major histocompatibility complex (MHC)-restricted cytotoxic T cells were demonstrated in 3 of 5 of the subgroup who were tested. Prolonged survival over 5 years in children with maternally acquired HIV-1 infection is associated with a high titer of neutralizing antibodies, a persistent production of IGM to HIV-1 envelope proteins and of IgG to p 17.

Topics

No keywords indexed for this article. Browse by subject →

Metrics

15

Citations

0

References

Details

Published: Apr 01, 1992
Vol/Issue: 8(4)
Pages: 435-442
License: View

Authors

P

Philippe Van de Perre

Pathogenesis and Control of Chronic Infections, Université de Montpellier, U 1058, 60 rue de Navacelles Montpellier, 34394 cedex 5, France.

Christiaan van Goethem

Cite This Article

Philippe Van de Perre, Philippe Lepage, Arlette Simonon, et al. (1992). Biological Markers Associated with Prolonged Survival in African Children Maternally Infected by the Human Immunodeficiency Virus Type 1. AIDS Research and Human Retroviruses, 8(4), 435-442. https://doi.org/10.1089/aid.1992.8.435

Biological Markers Associated with Prolonged Survival in African Children Maternally Infected by the Human Immunodeficiency Virus Type 1

You May Also Like