journal article May 01, 2020

The NLRP3 inflammasome in progressive multiple sclerosis

Brain Vol. 143 No. 5 pp. 1286-1288 · Oxford University Press (OUP)
View at Publisher Save 10.1093/brain/awaa135
Abstract
This scientific commentary refers to ‘NLRP3 inflammasome as prognostic factor and therapeutic target in primary progressive multiple sclerosis patients’, by Malhotra et al. (doi:10.1093/brain/awaa084).
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References
13
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Baecher-Allan "Multiple sclerosis: mechanisms and Immunotherapy" Neuron (2018) 10.1016/j.neuron.2018.01.021
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Barclay "Inflammasome activation in multiple sclerosis and experimental autoimmune encephalomyelitis (EAE)" Brain Pathol (2017) 10.1111/bpa.12477
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Beynon "Activated human CD4+CD45RO+ memory T-cells indirectly inhibit NLRP3 inflammasome activation through downregulation of P2X7R signalling" PLoS One (2012) 10.1371/journal.pone.0039576
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Chao "Metabolic control of astrocyte pathogenic activity via cPLA2-MAVS" Cell (2019) 10.1016/j.cell.2019.11.016
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Inflammasomes: mechanism of action, role in disease, and therapeutics

Haitao Guo, Justin B Callaway, Jenny P-Y Ting

Nature Medicine 2015 10.1038/nm.3893
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Interleukin-1  Alters Glutamate Transmission at Purkinje Cell Synapses in a Mouse Model of Multiple Sclerosis

G. Mandolesi, A. Musella, A. Gentile et al.

The Journal of Neuroscience 2013 10.1523/jneurosci.5369-12.2013
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Mascanfroni "IL-27 acts on DCs to suppress the T cell response and autoimmunity by inducing expression of the immunoregulatory molecule CD39" Nat Immunol (2013) 10.1038/ni.2695
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The NLRP3 inflammasome: molecular activation and regulation to therapeutics

Karen V. Swanson, Meng Deng, Jenny P.-Y. Ting

Nature Reviews Immunology 2019 10.1038/s41577-019-0165-0
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Verma "The Q705K polymorphism in NLRP3 is a gain-of-function alteration leading to excessive interleukin-1beta and IL-18 production" PLoS One (2012) 10.1371/journal.pone.0034977
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MAFG-driven astrocytes promote CNS inflammation

Michael A. Wheeler, Iain C. Clark, Emily C. Tjon et al.

Nature 2020 10.1038/s41586-020-1999-0
Metrics
17
Citations
13
References
Details
Published
May 01, 2020
Vol/Issue
143(5)
Pages
1286-1288
License
View
Funding
National Institutes of Health Award: RG4111A1
National Multiple Sclerosis Society
International Progressive MS Alliance
Work in the Quintana laboratory Award: NS102807
Cite This Article
Atsushi Kadowaki, Francisco J Quintana (2020). The NLRP3 inflammasome in progressive multiple sclerosis. Brain, 143(5), 1286-1288. https://doi.org/10.1093/brain/awaa135
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