Partial Efficacy of Low-Dose Naltrexone in Post-Orgasmic Illness Syndrome with Lichen Sclerosus: A Case Report

John Han Ye; Cherry Choudhary; Rowland W Rees; Bethany Brockbank; Georgios Kravvas; Christopher B Bunker

doi:10.1093/ced/llag152

journal article Apr 10, 2026

Partial Efficacy of Low-Dose Naltrexone in Post-Orgasmic Illness Syndrome with Lichen Sclerosus: A Case Report

John Han Ye Cherry Choudhary Rowland W Rees Bethany Brockbank Georgios Kravvas Christopher B Bunker

Clinical and Experimental Dermatology · Oxford University Press (OUP)

View at Publisher Save 10.1093/ced/llag152

Abstract

We report a patient with a symptom history consistent with post-orgasmic illness syndrome (POIS) and male genital lichen sclerosus (MGLSc), the first published case of a patient presenting with both conditions that have been associated with sexual dysfunction. The patient’s POIS symptoms persisted, despite MGLSc resolution post-circumcision. We report that naltrexone provided partial symptom relief for his POIS symptoms, offering a potential novel treatment approach.

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Published: Apr 10, 2026
License: View

Authors

J

John Han Ye

University College London Hospitals NHS Foundation Trust , UK

C

Cherry Choudhary

University College London Hospitals NHS Foundation Trust , UK

R

Rowland W Rees

University College London Hospitals NHS Foundation Trust , UK

B

Bethany Brockbank

University College London Hospitals NHS Foundation Trust , UK

G

Georgios Kravvas

University College London Hospitals NHS Foundation Trust , UK; University College London ,

C

Christopher B Bunker

University College London Hospitals NHS Foundation Trust , UK; University College London ,

Cite This Article

John Han Ye, Cherry Choudhary, Rowland W Rees, et al. (2026). Partial Efficacy of Low-Dose Naltrexone in Post-Orgasmic Illness Syndrome with Lichen Sclerosus: A Case Report. Clinical and Experimental Dermatology. https://doi.org/10.1093/ced/llag152

Partial Efficacy of Low-Dose Naltrexone in Post-Orgasmic Illness Syndrome with Lichen Sclerosus: A Case Report

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