High-fat diet-induced obesity accelerates the progression of spontaneous osteoarthritis in senescence-accelerated mouse prone 8

Chenyang Ding; Dilimulati Yimiti; Yohei Sanada; Yuki Matsubara; Tomoyuki Nakasa; Kiminori Matsubara; Nobuo Adachi; Shigeru Miyaki

doi:10.1093/mr/road069

journal article Jul 31, 2023

High-fat diet-induced obesity accelerates the progression of spontaneous osteoarthritis in senescence-accelerated mouse prone 8

Chenyang Ding

Dilimulati Yimiti Yohei Sanada Yuki Matsubara Tomoyuki Nakasa Kiminori Matsubara Nobuo Adachi Shigeru Miyaki

Modern Rheumatology Vol. 34 No. 4 pp. 831-840 · Oxford University Press (OUP)

View at Publisher Save 10.1093/mr/road069

Abstract

ABSTRACT

Objectives
Ageing and obesity are major risk factors for osteoarthritis (OA), a widespread disease currently lacking efficient treatments. Senescence-accelerated mouse prone 8 (SAMP8) display early onset ageing phenotypes, including OA. This study investigates the impacts of high-fat diet (HFD)-induced obesity on OA development in SAMP8.

Methods
SAMP8 at 5 weeks were fed either a normal chow diet or an HFD for 10 weeks to induce obesity. Parameters related to obesity, liver function, and lipid and glucose metabolism were analysed. At 14 weeks of age, knee joint pathology, bone mineral density, and muscle strength were assessed. Immunohistochemistry and TUNEL staining were performed to evaluate markers for cartilage degeneration and chondrocyte apoptosis.

Results
At 14 weeks of age, HFD-induced obesity increased liver and adipose tissue inflammation in SAMP8 without further exacerbating diabetes. Histological scoring revealed aggravated cartilage, menisci deterioration, and synovitis, while no further loss of bone mineral density or muscle strength was observed. Increased chondrocyte apoptosis was detected in knee joints following HFD feeding.

Conclusions
Ten weeks of HFD feeding promotes spontaneous OA progression in 14-week-old SAMP8, potentially via liver damage that subsequently leads to chondrocyte apoptosis. This ageing-obese mouse model may prove valuable for further exploration of spontaneous OA pathophysiology.

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Metrics

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Citations

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References

Details

Published: Jul 31, 2023
Vol/Issue: 34(4)
Pages: 831-840
License: View

Authors

C

Chenyang Ding

Department of Orthopaedic Surgery, Graduate School of Biomedical and Health Sciences, Hiroshima University , Hiroshima, Japan

D

Dilimulati Yimiti

Department of Orthopaedic Surgery, Graduate School of Biomedical and Health Sciences, Hiroshima University , Hiroshima, Japan

Y

Yohei Sanada

Department of Orthopaedic Surgery, Graduate School of Biomedical and Health Sciences, Hiroshima University , Hiroshima, Japan; Medical Center for Translational and Clinical Research, Hiroshima University Hospital , Hiroshima, Japan

Y

Yuki Matsubara

Department of Orthopaedic Surgery, Graduate School of Biomedical and Health Sciences, Hiroshima University , Hiroshima, Japan

T

Tomoyuki Nakasa

Department of Artificial Joints and Biomaterials, Graduate School of Biomedical and Health Sciences, Hiroshima University , Hiroshima, Japan

K

Kiminori Matsubara

Department of Human Life Science Education, Graduate School of Education, Hiroshima University , Higashi-Hiroshima, Japan

N

Nobuo Adachi

Department of Orthopaedic Surgery, Graduate School of Biomedical and Health Sciences, Hiroshima University , Hiroshima, Japan

S

Shigeru Miyaki

Department of Orthopaedic Surgery, Graduate School of Biomedical and Health Sciences, Hiroshima University , Hiroshima, Japan; Medical Center for Translational and Clinical Research, Hiroshima University Hospital , Hiroshima, Japan

Cite This Article

Chenyang Ding, Dilimulati Yimiti, Yohei Sanada, et al. (2023). High-fat diet-induced obesity accelerates the progression of spontaneous osteoarthritis in senescence-accelerated mouse prone 8. Modern Rheumatology, 34(4), 831-840. https://doi.org/10.1093/mr/road069

High-fat diet-induced obesity accelerates the progression of spontaneous osteoarthritis in senescence-accelerated mouse prone 8

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