Charles F. Prentice Award Lecture 2006: A Neuron Doctrine for Glaucoma

Ronald S. Harwerth

doi:10.1097/opx.0b013e31817841b5

journal article Jun 01, 2008

Charles F. Prentice Award Lecture 2006: A Neuron Doctrine for Glaucoma

Ronald S. Harwerth

Optometry and Vision Science Vol. 85 No. 6 · Wiley

View at Publisher Save 10.1097/opx.0b013e31817841b5

Abstract

ABSTRACT

The glaucomas are a group of potentially blinding optic neuropathies that are characterized by progressive pathological losses of the retinal ganglion cells (RGCs) and their axons that form the optic nerve. The causes are unknown and, therefore, the diagnosis and assessment of progression of disease depends on ophthalmic testing to identify and quantify clinical characteristics of glaucomatous neuropathy, such as the pattern of visual field defects and/or thinning of the retinal nerve fiber layer. To relate these clinical measurements to the basic pathology of glaucoma, a neuron doctrine for glaucoma has been proposed to correlate data from standard tests (standard automated perimetry and optical coherence tomography) to the loss of RGCs. The doctrine was derived through initial laboratory studies of experimental glaucoma in macaque monkeys and, then, modified and refined though patient‐based clinical investigations. The final formulation of the doctrine produced concordance between subjective and objective measurements when the results were translated to their common parameter of RGCs, for both normal vision and defective vision from glaucoma. Thus, it was concluded that for individual patients, alterations in structure‐function relationships usually should be in agreement for the degree and location of visual field defects caused by glaucoma.

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Structure and Function in Patients with Glaucomatous Defects Near Fixation

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Metrics

15

Citations

32

References

Details

Published: Jun 01, 2008
Vol/Issue: 85(6)
License: View

Authors

R

Ronald S. Harwerth

College of Optometry University of Houston Houston Texas

Funding

National Eye Institute

Cite This Article

Ronald S. Harwerth (2008). Charles F. Prentice Award Lecture 2006: A Neuron Doctrine for Glaucoma. Optometry and Vision Science, 85(6). https://doi.org/10.1097/opx.0b013e31817841b5

Charles F. Prentice Award Lecture 2006: A Neuron Doctrine for Glaucoma

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