Chronic food restriction enhances dopamine-mediated intracranial self-stimulation

Federico G. Gnazzo; Devry Mourra; Christopher A. Guevara; Jeff A. Beeler

doi:10.1097/wnr.0000000000001700

journal article Jul 19, 2021

Chronic food restriction enhances dopamine-mediated intracranial self-stimulation

Federico G. Gnazzo Devry Mourra

Christopher A. Guevara Jeff A. Beeler

NeuroReport Vol. 32 No. 13 pp. 1128-1133 · Ovid Technologies (Wolters Kluwer Health)

View at Publisher Save 10.1097/wnr.0000000000001700

Abstract

Dopamine-mediated reinforcement and behavioral adaptation is essential to survival. Here, we test the effects of food restriction on dopamine-mediated learning and reinforcement using optical intracranial self-stimulation (oICSS), an optogenetic version of conventional electrical ICSS (also known as brain stimulation reward, BSR). Using mouse genetic lines to express channelrhodopsin selectively in midbrain dopamine neurons, we demonstrate that genetically expressed channelrhodopsin can mediate optically evoked dopamine release and support self-stimulation in a lever-pressing paradigm. Using this midbrain dopamine oICSS preparation, we compare acquisition and rate of pressing in ad libitum versus food restricted mice. Food restriction facilitated both more rapid acquisition of self-stimulation behavior and higher rates of responding; reversing food status after acquisition modulated response vigor in already established behavior. These data suggest that food restriction enhances both the acquisition and expression of dopamine-reinforced self-stimulation responding. These data demonstrate the utility of oICSS for examining changes in reinforcement learning concomitant to neuroadaptations induced in dopamine signaling by experimental manipulations such as food restriction.

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Metrics

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Citations

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References

Details

Published: Jul 19, 2021
Vol/Issue: 32(13)
Pages: 1128-1133

Authors

F

Federico G. Gnazzo

Department of Psychology, Queens College

D

Devry Mourra

Department of Psychology, Queens College; CUNY Neuroscience Collaborative, The Graduate Center, City University New York

C

Christopher A. Guevara

Department of Psychology, Queens College; Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, New York, USA

J

Jeff A. Beeler

Department of Psychology, Queens College; CUNY Neuroscience Collaborative, The Graduate Center, City University New York; Biology Program, The Graduate Center, City University New York

Cite This Article

Federico G. Gnazzo, Devry Mourra, Christopher A. Guevara, et al. (2021). Chronic food restriction enhances dopamine-mediated intracranial self-stimulation. NeuroReport, 32(13), 1128-1133. https://doi.org/10.1097/wnr.0000000000001700

Chronic food restriction enhances dopamine-mediated intracranial self-stimulation

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