ToxigenicCorynebacterium ulceransisolated from a hunting dog and its diphtheria toxin antibody titer

Chihiro Katsukawa; Takako Komiya; Kaoru Umeda; Minami Goto; Tokuma YANAI; Motohide Takahashi; Akihiko Yamamoto; Masaaki Iwaki

doi:10.1111/1348-0421.12364

journal article Mar 01, 2016

ToxigenicCorynebacterium ulceransisolated from a hunting dog and its diphtheria toxin antibody titer

Chihiro Katsukawa Takako Komiya Kaoru Umeda Minami Goto Tokuma YANAI Motohide Takahashi Akihiko Yamamoto Masaaki Iwaki

Microbiology and Immunology Vol. 60 No. 3 pp. 177-186 · Wiley

View at Publisher Save 10.1111/1348-0421.12364

Abstract

ABSTRACTToxigenicCorynebacterium ulceransis a zoonotic pathogen that produces diphtheria toxin and causes a diphtheria‐like illness in humans. The organism is known to infect and circulate among dogs, which can then transmit it to humans. Furthermore, previous studies have found thatC. ulceransis carried by wild animals, including game animals. In the present study, we tested hunting and companion dogs for the presence of toxigenicC. ulceransand succeeded in isolating the bacterium from a hunting dog. Moreover, several hunting dogs had serum diphtheria antitoxin titers that were higher than the titers required for protection in humans, suggesting a history of exposure to toxigenicCorynebacteriumstrains. Notably, ribotyping, pulsed‐field gel electrophoresis andtoxgene sequencing demonstrated that the isolate from the hunting dog clustered with previously characterizedC. ulceransstrains isolated from wild animals, as opposed to groups of isolates from humans and companion dogs. Interestingly, the wild animal cluster also contains an isolate from an outdoor breeding dog, which could have formed a bridge between isolates from wild animals and those from companion dogs. The results presented herein provide insight into the mechanism by which the zoonotic pathogenC. ulceranscirculates among wild animals, hunting and companion dogs, and humans.

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References

Details

Published: Mar 01, 2016
Vol/Issue: 60(3)
Pages: 177-186
License: View

Authors

C

Chihiro Katsukawa

Department of Infectious Diseases Osaka Prefectural Institute of Public Health 1‐3‐69 Nakamichi Higashinari‐ku Osaka‐shi, Osaka 537‐0025

T

Takako Komiya

Department of Bacteriology II National Institute of Infectious Diseases 4‐7‐1 Gakuen Musashimurayama‐shi Tokyo 208‐0011

K

Kaoru Umeda

Department of Microbiology Osaka City Institute of Public Health and Environmental Sciences 8‐34 Tojo‐cho Tennoji‐ku Osaka‐shi, Osaka 543‐0026

M

Minami Goto

Department of Pathogenetic Veterinary Sciences, United Graduate School of Veterinary Sciences Gifu University 1‐1 Yanagido Gifu‐shi Gifu 501‐1193 Japan

T

Tokuma YANAI

Department of Pathogenetic Veterinary Sciences, United Graduate School of Veterinary Sciences Gifu University 1‐1 Yanagido Gifu‐shi Gifu 501‐1193 Japan

M

Motohide Takahashi

Department of Bacteriology II National Institute of Infectious Diseases 4‐7‐1 Gakuen Musashimurayama‐shi Tokyo 208‐0011

A

Akihiko Yamamoto

Department of Bacteriology II National Institute of Infectious Diseases 4‐7‐1 Gakuen Musashimurayama‐shi Tokyo 208‐0011

M

Masaaki Iwaki

Department of Bacteriology II National Institute of Infectious Diseases 4‐7‐1 Gakuen Musashimurayama‐shi Tokyo 208‐0011

Funding

Ministry of Health, Labour and Welfare

Cite This Article

Chihiro Katsukawa, Takako Komiya, Kaoru Umeda, et al. (2016). ToxigenicCorynebacterium ulceransisolated from a hunting dog and its diphtheria toxin antibody titer. Microbiology and Immunology, 60(3), 177-186. https://doi.org/10.1111/1348-0421.12364

ToxigenicCorynebacterium ulceransisolated from a hunting dog and its diphtheria toxin antibody titer

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