Melatonin inhibits the proliferation of breast cancer cells induced by bisphenol A via targeting estrogen receptor‐related pathways

Tianjiao Wang; Bowen Liu; Yanan Guan; Miaomiao Gong; Jinjin Pan; Yanan Liu; Rui Liang; Yuhui Yuan; Lihong Ye

doi:10.1111/1759-7714.12587

journal article Open Access Jan 13, 2018

Melatonin inhibits the proliferation of breast cancer cells induced by bisphenol A via targeting estrogen receptor‐related pathways

Tianjiao Wang

Bowen Liu

Yanan Guan Miaomiao Gong

Jinjin Pan Yanan Liu

Rui Liang

Yuhui Yuan

Lihong Ye

Thoracic Cancer Vol. 9 No. 3 pp. 368-375 · Wiley

View at Publisher Save 10.1111/1759-7714.12587

Abstract

BackgroundBackground: Bisphenol A (BPA) is an estrogen‐like chemical widely contained in daily supplies. There is evidence that environmental exposure to BPA could contribute to the development of hormone‐related cancers. As is reported in numerous studies, melatonin, an endogenous hormone secreted by the pineal gland, could markedly inhibit estrogen‐induced proliferation of breast cancer (BC) cells. In this study, we intended to reveal the effects of melatonin on BPA‐induced proliferation of estrogen receptor‐positive BC cells.MethodsMethods: We used methyl thiazolyl tetrazolium, luciferase reporter gene and western blotting assays to testify the effect of melatonin on BPA‐mediated proliferation of MCF‐7 and T47D cells.ResultsMethyl thiazolyl tetrazolium and colony formation assays showed that melatonin could significantly abolish BPA‐elevated cell proliferation. Meanwhile, BPA‐upregulated phosphorylation of ERK and AKT was decreased by melatonin treatment. Mechanistically, we found that BPA was capable of upregulating the protein levels of steroid receptor coactivators (SRC‐1, SRC‐3), as well as promoting the estrogen response element activity. However, the addition of melatonin could remarkably block the elevation of steroid receptor coactivators expression and estrogen response element activity triggered by BPA.ConclusionConclusions: Therefore, these results demonstrated that melatonin could abrogate BPA‐induced proliferation of BC cells. Therapeutically, melatonin could be regarded as a potential medication for BPA‐associated BC.

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References

Details

Published: Jan 13, 2018
Vol/Issue: 9(3)
Pages: 368-375
License: View

Authors

T

Tianjiao Wang

State Key Laboratory of Medicinal Chemical Biology, Department of Biochemistry, College of Life Sciences Nankai University Tianjin China; Department of General Surgery, The Second Affiliated Hospital Institute of Cancer Stem Cell, Dalian Medical University Cancer Center Dalian China

B

Bowen Liu

State Key Laboratory of Medicinal Chemical Biology, Department of Biochemistry, College of Life Sciences Nankai University Tianjin China

Y

Yanan Guan